| AIHC Capital Management Ltd Hedge fund | 54.5% | $56.8m | 303,133 | −63% | reduced |
| Darwin Global Management, Ltd. Hedge fund | 54.5% | $2.0bn | 10.63m | +381% | added |
| MIC Capital Management UK LLP Hedge fund | 25.3% | $99.6m | 531,733 | −33% | reduced |
| Casdin Capital, LLC Hedge fund | 24.2% | $483m | 2.58m | 0.0% | held |
| Paradigm Biocapital Advisors LP Hedge fund | 22.3% | $1.2bn | 6.36m | −4.4% | reduced |
| DAFNA Capital Management LLC Hedge fund | 20.1% | $105m | 562,630 | −3.1% | reduced |
| Checkpoint Capital L.P. Hedge fund | 19.7% | $76.9m | 410,353 | +56% | added |
| Caligan Partners LP Hedge fund | 17.7% | $367m | 1.96m | +19% | added |
| Farallon Capital Management, L.L.C. Hedge fund | 14.9% | $2.5bn | 13.55m | −0.4% | held |
| Integral Health Asset Management, LLC Hedge fund | 11.5% | $281m | 1.50m | 0.0% | held |
| Baker Bros. Advisors LP Hedge fund | 10.7% | $2.1bn | 11.44m | +20% | added |
| Rock Springs Capital Management LP Hedge fund | 10.1% | $207m | 1.11m | −8.6% | reduced |
| Diadema Partners LP Hedge fund | 9.2% | $26.1m | 139,218 | +72% | added |
| Seven Fleet Capital Management LP Hedge fund | 7.5% | $45.3m | 242,029 | +200% | added |
| Boxer Capital Management, LLC Hedge fund | 7.1% | $93.6m | 500,000 | 0.0% | held |
| Artia Global Partners LP Hedge fund | 6.6% | $34.7m | 185,390 | +48% | added |
| Superstring Capital Management LP Hedge fund | 6.0% | $9.6m | 51,053 | – | new |
| Logos Global Management LP Hedge fund | 5.6% | $131m | 700,000 | −65% | reduced |
| MPM Bioimpact LLC Hedge fund | 5.6% | $92.2m | 492,483 | −2.8% | reduced |
| Stempoint Capital LP Hedge fund | 5.2% | $30.0m | 159,943 | −43% | reduced |
| PSquared Asset Management AG Hedge fund | 4.9% | $15.0m | 80,000 | −42% | reduced |
| Deerfield Management Company, L.P. Hedge fund | 4.7% | $448m | 2.39m | +4.1% | added |
| Avoro Capital Advisors LLC Hedge fund | 3.9% | $430m | 2.30m | −2.0% | reduced |
| Eagle Health Investments LP Hedge fund | 3.7% | $22.5m | 120,346 | +0.7% | added |
| Tri Locum Partners LP Hedge fund | 3.5% | $28.4m | 151,822 | – | new |
| Trails Edge Capital Partners, LP Hedge fund | 3.4% | $21.7m | 115,750 | −53% | reduced |
| Birnam Oak Advisors, LP Hedge fund | 3.3% | $20.2m | 107,644 | −32% | reduced |
| HighVista Strategies LLC Hedge fund | 2.9% | $12.5m | 66,983 | −3.4% | reduced |
| PFM Health Sciences, LP Hedge fund | 2.3% | $26.8m | 143,222 | +1.7% | added |
| Affinity Asset Advisors, LLC Hedge fund | 2.3% | $46.8m | 250,000 | +150% | added |
| Persistent Asset Partners Ltd Hedge fund | 2.3% | $7.3m | 38,726 | +49% | added |
| Cannon Global Investment Management, LLC Hedge fund | 2.3% | $749k | 4,000 | −53% | reduced |
| Melqart Asset Management (UK) Ltd Hedge fund | 2.2% | $22.7m | 121,308 | −55% | reduced |
| Nwi Management LP Hedge fund | 2.2% | $33.7m | 180,000 | – | new |
| Defilade Capital Management, L.P. Hedge fund | 2.1% | $15.5m | 82,827 | −74% | reduced |
| Zweig-DiMenna Associates LLC Hedge fund | 2.0% | $22.5m | 120,200 | +1350% | added |
| Vestal Point Capital, LP Hedge fund | 2.0% | $84.3m | 450,000 | −81% | reduced |
| Duquesne Family Office LLC Family office | 1.7% | $74.8m | 399,587 | +27% | added |
| Opaleye Management Inc. Hedge fund | 1.7% | $18.7m | 100,000 | 0.0% | held |
| Atika Capital Management LLC Hedge fund | 1.6% | $16.5m | 88,000 | – | new |
| Boothbay Fund Management, LLC Hedge fund | 1.6% | $87.2m | 465,787 | +6.2% | added |
| Perceptive Advisors LLC Hedge fund | 1.5% | $98.8m | 527,600 | +104% | added |
| Rangeley Capital, LLC Hedge fund | 1.5% | $1.6m | 8,700 | −87% | reduced |
| Decheng Capital LLC Hedge fund | 1.3% | $9.9m | 52,667 | −44% | reduced |
| Quarry LP Hedge fund | 1.2% | $7.5m | 40,175 | −32% | reduced |
| Woodline Partners LP Hedge fund | 1.2% | $375m | 2.00m | −20% | reduced |
| Monimus Capital Management, LP Hedge fund | 1.0% | $3.9m | 20,845 | +9.1% | added |
| Sandler Capital Management Hedge fund | 0.9% | $1.6m | 8,328 | – | new |
| ADAR1 Capital Management, LLC Hedge fund | 0.8% | $16.4m | 87,509 | −35% | reduced |
| Verdad Advisers, LP Hedge fund | 0.7% | $759k | 4,053 | −81% | reduced |
| Militia Capital Management LLC Hedge fund | 0.7% | $3.7m | 20,000 | – | new |
| Sphera Funds Management Ltd. Hedge fund | 0.6% | $4.2m | 22,400 | −59% | reduced |
| Holocene Advisors, LP Hedge fund | 0.6% | $255m | 1.36m | −45% | reduced |
| Empyrean Capital Partners, LP Hedge fund | 0.5% | $14.1m | 75,400 | −26% | reduced |
| Greenland Capital Management LP Hedge fund | 0.5% | $2.6m | 14,000 | +4.2% | added |
| Samlyn Capital, LLC Hedge fund | 0.5% | $28.3m | 151,290 | −59% | reduced |
| Candriam S.C.A. Hedge fund | 0.5% | $104m | 556,392 | −4.2% | reduced |
| Bronte Capital Management Pty Ltd. Hedge fund | 0.4% | $3.5m | 18,780 | – | new |
| Polar Capital Holdings Plc Hedge fund | 0.4% | $129m | 690,316 | −39% | reduced |
| Moore Capital Management, LP Hedge fund | 0.3% | $15.3m | 81,700 | +47% | added |
| Anson Funds Management LP Hedge fund | 0.3% | $3.7m | 20,000 | – | new |
| Burkehill Global Management, LP Hedge fund | 0.3% | $9.4m | 50,000 | – | new |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. Hedge fund | 0.3% | $1.1m | 6,100 | −23% | reduced |
| Sona Asset Management (US) LLC Hedge fund | 0.3% | $8.7m | 46,450 | – | new |
| Alyeska Investment Group, L.P. Hedge fund | 0.3% | $123m | 659,279 | −65% | reduced |
| Seven Grand Managers, LLC Hedge fund | 0.3% | $7.5m | 40,000 | – | new |
| Readystate Asset Management LP Hedge fund | 0.3% | $7.1m | 37,727 | +18% | added |
| Orbimed Advisors LLC Hedge fund | 0.3% | $13.2m | 70,500 | +36% | added |
| Machina Capital S.A.S. Hedge fund | 0.2% | $1.4m | 7,540 | −3.8% | reduced |
| ABS Investment Management LLC Hedge fund | 0.2% | $337k | 187 | – | |
| Silverarc Capital Management, LLC Hedge fund | 0.2% | $1.9m | 10,000 | – | new |
| Cinctive Capital Management LP Hedge fund | 0.2% | $5.0m | 26,661 | −72% | reduced |
| Dymon Asia Capital (Singapore) Pte. Ltd. Hedge fund | 0.2% | $1.2m | 6,500 | – | new |
| Oxford Asset Management LLP Hedge fund | 0.2% | $384k | 2,050 | −78% | reduced |
| Ghisallo Capital Management LLC Hedge fund | 0.2% | $9.4m | 50,000 | – | new |
| EntryPoint Capital, LLC Hedge fund | 0.2% | $669k | 3,574 | −3.4% | reduced |
| Adage Capital Partners GP, L.L.C. Hedge fund | 0.2% | $112m | 597,226 | −89% | reduced |
| Prelude Capital Management, LLC Hedge fund | 0.2% | $2.1m | 10,997 | −36% | reduced |
| Trexquant Investment LP Hedge fund | 0.1% | $22.5m | 120,122 | +75% | added |
| GABELLI & Co INVESTMENT ADVISERS, INC. Hedge fund | 0.1% | $833k | 4,450 | −67% | reduced |
| Two Sigma Investments, LP Hedge fund | 0.1% | $138m | 737,697 | −53% | reduced |
| Dark Forest Capital Management LP Hedge fund | 0.10% | $1.5m | 8,237 | −18% | reduced |
| AQR Capital Management LLC Hedge fund | 0.08% | $243m | 1.30m | +1009% | added |
| Freestone Grove Partners LP Hedge fund | 0.08% | $12.1m | 64,813 | – | new |
| ExodusPoint Capital Management, LP Hedge fund | 0.08% | $8.2m | 44,020 | +318% | added |
| Eversept Partners, LP Hedge fund | 0.07% | $1.3m | 6,943 | – | new |
| Lighthouse Investment Partners, LLC Hedge fund | 0.07% | $2.2m | 11,905 | – | new |
| Qube Research & Technologies Ltd Hedge fund | 0.07% | $58.9m | 314,365 | −43% | reduced |
| Citadel Advisors LLC Hedge fund | 0.06% | $110m | 589,906 | +47% | added |
| FORA Capital, LLC Hedge fund | 0.06% | $818k | 4,368 | −71% | reduced |
| Baillie Gifford Long-only investor | 0.04% | $49.3m | 263,466 | +41% | added |
| IFM Investors Pty Ltd Hedge fund | 0.04% | $6.6m | 35,035 | +22% | added |
| Quantbot Technologies LP Hedge fund | 0.04% | $1.1m | 5,724 | −10% | reduced |
| Marshall Wace, LLP Hedge fund | 0.04% | $45.8m | 244,544 | +13% | added |
| Schonfeld Strategic Advisors LLC Hedge fund | 0.03% | $6.4m | 34,061 | – | new |
| Edgestream Partners, L.P. Hedge fund | 0.03% | $1.1m | 5,907 | −91% | reduced |
| Centiva Capital, LP Hedge fund | 0.03% | $956k | 5,107 | −32% | reduced |
| Millennium Management LLC Hedge fund | 0.03% | $40.5m | 216,208 | −43% | reduced |
| WCM Investment Management Long-only investor | 0.02% | $11.2m | 58,074 | −45% | reduced |
| Engineers Gate Manager LP Hedge fund | 0.02% | $1.4m | 7,380 | +144% | added |
| Point72 Asset Management, L.P. Hedge fund | 0.02% | $11.3m | 60,276 | – | new |
| Governors Lane LP Hedge fund | 0.02% | $153k | 818 | – | new |
| Brevan Howard Capital Management LP Hedge fund | 0.01% | $914k | 4,883 | −70% | reduced |
| Tudor Investment Corp ET AL Hedge fund | 0.01% | $3.0m | 16,000 | −82% | reduced |
| Hudson Bay Capital Management LP Hedge fund | 0.01% | $2.3m | 12,500 | −38% | reduced |
| Capstone Investment Advisors, LLC Hedge fund | 0.01% | $1.3m | 7,200 | – | new |
| Jain Global LLC Hedge fund | 0.0% | $314k | 1,676 | – | new |
| D. E. Shaw & Co., Inc. Hedge fund | 0.0% | $2.3m | 12,400 | −99% | reduced |
| CVA Family Office, LLC Family office | 0.0% | $6.0k | 32 | – | new |