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Dafna Capital Management LLC: 13F holdings, Q2 2026

Hedge fund · SEC EDGAR filings (CIK 1389933) · Explore on the interactive board

Dafna Capital Management LLC disclosed 88 US equity positions worth $524.4m in its Q2 2026 13F filing (holdings as of June 30, 2026, filed August 14, 2026). Its largest position is RVMD at 20.1% of the reported book, followed by XBI, CMPS. The top ten holdings are 56.2% of the book, and the portfolio behaves like about 16 equal-weight positions. Versus the prior filing it opened 17 new positions, added to 17, reduced 25 and exited 12. Note: this manager's most recent filing is 3934 quarters behind the newest quarter on file, so these figures are history rather than current positioning.

This manager's most recent filing is 3934 quarter(s) behind the newest quarter on file. Treat these figures as history, not current positioning.
$524.4mreported US equity book
88positions
20.1%largest position
56.2%top 10 weight
16.41effective positions (1/HHI)
2quarters on file since Q1 2026

What does Dafna Capital Management LLC own? Top holdings as of June 30, 2026

Change is measured in shares against the previous filing (Q1 2026), so price moves do not read as decisions. This quarter: 17 new, 17 added, 25 reduced, 12 exited.

#StockSectorWeightValueSharesΔ sharesAction
1 RVMD REVOLUTION MEDICINES INC Healthcare 20.1%$105.4m562,630 -3% reduced
2 XBI SPDR S&P BIOTECH ETF 5.9%$31.1m196,505 -38% reduced
3 CMPS COMPASS PATHWAYS PLC Healthcare 5.4%$28.5m2,011,952 -17% reduced
4 STXS STEREOTAXIS INC 4.5%$23.5m13,680,554 0% held
5 NKTR NEKTAR THERAPEUTICS Healthcare 4.2%$22.2m318,380 93% added
6 DNLI DENALI THERAPEUTICS INC Healthcare 3.6%$19.0m739,014 132% added
7 IDYA IDEAYA BIOSCIENCES INC Healthcare 3.5%$18.5m497,240 4% added
8 ATRC ATRICURE INC Healthcare 3.2%$16.7m597,431 0% held
9 XENE XENON PHARMACEUTICALS INC Healthcare 2.9%$15.1m250,772 0% held
10 CYTK CYTOKINETICS INC Healthcare 2.8%$14.7m171,998 -21% reduced
11 RCUS ARCUS BIOSCIENCES INC Healthcare 2.6%$13.6m441,829 -0% held
12 ASND ASCENDIS PHARMA A/S Healthcare 2.5%$12.9m48,469 new
13 NBIX NEUROCRINE BIOSCIENCES INC Healthcare 1.9%$9.7m57,769 -18% reduced
14 AXGN AXOGEN INC Healthcare 1.8%$9.7m208,960 -16% reduced
15 PODD INSULET CORP Healthcare 1.8%$9.4m61,870 469% added
16 EWTX EDGEWISE THERAPEUTICS INC Healthcare 1.8%$9.2m226,819 102% added
17 BCAX BICARA THERAPEUTICS INC Healthcare 1.6%$8.5m284,955 -32% reduced
18 IBB ISHARES NASDAQ BIOTECH INDX 1.5%$8.1m42,595 -31% reduced
19 SNDX SYNDAX PHARMACEUTICALS INC Healthcare 1.4%$7.3m335,255 54% added
20 MPLT MAPLIGHT THERAPEUTICS INC 1.2%$6.1m171,006 0% held
21 LRMR LARIMAR THERAPEUTICS INC Healthcare 1.2%$6.1m2,008,164 -1% reduced
22 IPSC CENTURY THERAPEUTICS INC Healthcare 1.1%$5.9m2,400,458 -1% reduced
23 DXCM DEXCOM INC Healthcare 1.1%$5.8m86,279 0% held
24 IMVT IMMUNOVANT INC Healthcare 1.1%$5.8m149,524 -1% reduced
25 INGN INOGEN INC Healthcare 1.0%$5.5m845,179 0% held
26 TNDM TANDEM DIABETES CARE INC Healthcare 1.0%$5.4m355,208 0% held
27 ALKS ALKERMES PLC Healthcare 1.0%$5.3m101,266 -27% reduced
28 STOK STOKE THERAPEUTICS INC Healthcare 0.8%$4.3m130,875 0% held
29 ALLO ALLOGENE THERAPEUTICS INC Healthcare 0.8%$4.2m2,000,000 46% added
30 BCRX BIOCRYST PHARMACEUTICALS INC Healthcare 0.8%$4.0m400,248 -7% reduced
31 LKFT LAKEFRONT BIOTHERAPEUTICS NV Healthcare 0.7%$3.9m130,175 0% held
32 KIDS ORTHOPEDIATRICS CORP Healthcare 0.7%$3.6m189,130 98% added
33 HELP CYBIN INC 0.6%$3.4m514,061 3% added
34 RAPP RAPPORT THERAPEUTICS INC 0.6%$3.1m75,000 0% held
35 KYMR KYMERA THERAPEUTICS INC Healthcare 0.6%$3.1m27,000 new
36 PROQR THERAPEUTICS NV 0.5%$2.8m1,530,361 -2% reduced
37 NGNE NEUROGENE INC 0.5%$2.8m89,032 57% added
38 ANL ADLAI NORTYE LTD 0.5%$2.8m239,553 new
39 PRCT PROCEPT BIOROBOTICS CORP Healthcare 0.5%$2.7m120,000 0% held
40 AQST AQUESTIVE THERAPEUTICS INC 0.5%$2.7m645,915 75% added
41 CLDX CELLDEX THERAPEUTICS INC Healthcare 0.5%$2.5m68,518 0% held
42 GPCR STRUCTURE THERAPEUTICS INC Healthcare 0.5%$2.5m46,500 0% held
43 ALGN ALIGN TECHNOLOGY INC Healthcare 0.5%$2.4m14,000 -7% reduced
44 VKTX VIKING THERAPEUTICS INC Healthcare 0.4%$2.3m59,516 0% held
45 NERVGEN PHARMA CORP 0.4%$2.2m1,050,000 new
46 BHVN BIOHAVEN LTD Healthcare 0.4%$2.0m137,593 -84% reduced
47 MAZE MAZE THERAPEUTICS INC Healthcare 0.4%$1.9m65,000 86% added
48 ALEC ALECTOR INC Healthcare 0.3%$1.8m908,351 0% held
49 LXEO LEXEO THERAPEUTICS INC Healthcare 0.3%$1.8m377,059 0% held
50 PROF PROFOUND MEDICAL CORP 0.3%$1.7m260,360 -1% reduced

What did Dafna Capital Management LLC sell? Positions exited since the previous filing

StockPrior weightPrior value
DAWNGBX DAY ONE BIOPHARMACEUTICALS I47.4%$21.0m
ASND ASCENDIS PHARMA A/S13.4%$5.9m
4XC1 KALVISTA PHARMACEUTICALS INC12.2%$5.4m
ASND ASCENDIS PHARMA A/S12.0%$5.3m
FULC FULCRUM THERAPEUTICS INC3.6%$1.6m
ENGENE HOLDINGS INC2.9%$1.3m
SCYX SCYNEXIS INC2.3%$996.6k
ORIC ORIC PHARMACEUTICALS INC2.1%$945.5k
ZBIO ZENAS BIOPHARMA INC1.9%$830.9k
NEWAMSTERDAM PHARMA CO1.4%$640.2k
KPTI KARYOPHARM THERAPEUTICS INC0.6%$255.1k
NMRA NEUMORA THERAPEUTICS INC0.3%$136.5k

Sector mix

SectorWeight
Healthcare80.8%

Sectors cover positions whose ticker resolved to a sector; the remainder is unclassified, not cash.

Filing history

QuarterPositionsEquity value
Q2 202688$524.4m
Q1 202683$439.6m

How concentrated is Dafna Capital Management LLC's portfolio?

Across every quarter Dafna Capital Management LLC has filed, its median largest position is 16.5% of the book and its median top-ten weight is 54.3%, which WhaleCreep classifies as concentrated (the gate is a median largest position of 5%). Of 9.0 completed holding spells, the median lasted 1.0 quarters; 88.0 positions are still open and their final length is unknown.