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Perceptive Advisors LLC: 13F holdings, Q2 2026

Hedge fund · SEC EDGAR filings (CIK 1224962) · Explore on the interactive board

Perceptive Advisors LLC disclosed 102 US equity positions worth $6.4bn in its Q2 2026 13F filing (holdings as of June 30, 2026, filed August 14, 2026). Its largest position is PRAX at 10.6% of the reported book, followed by SYRE, CELC. The top ten holdings are 48.9% of the book, and the portfolio behaves like about 28 equal-weight positions. Versus the prior filing it opened 23 new positions, added to 29, reduced 26 and exited 13. Note: this manager's most recent filing is 3934 quarters behind the newest quarter on file, so these figures are history rather than current positioning.

This manager's most recent filing is 3934 quarter(s) behind the newest quarter on file. Treat these figures as history, not current positioning.
$6.4bnreported US equity book
102positions
10.6%largest position
48.9%top 10 weight
28.42effective positions (1/HHI)
2quarters on file since Q1 2026

What does Perceptive Advisors LLC own? Top holdings as of June 30, 2026

Change is measured in shares against the previous filing (Q1 2026), so price moves do not read as decisions. This quarter: 23 new, 29 added, 26 reduced, 13 exited.

#StockSectorWeightValueSharesΔ sharesAction
1 PRAX PRAXIS PRECISION MEDICINES I Healthcare 10.6%$681.6m2,035,986 0% held
2 SYRE SPYRE THERAPEUTICS INC Healthcare 6.0%$383.5m4,319,496 14% added
3 CELC CELCUITY INC Healthcare 5.2%$334.5m3,197,200 2% added
4 ASND ASCENDIS PHARMA A/S Healthcare 4.8%$310.4m1,163,721 new
5 RYTM RHYTHM PHARMACEUTICALS INC Healthcare 4.5%$287.2m2,586,295 9% added
6 ROIV ROIVANT SCIENCES LTD Healthcare 4.4%$286.1m8,085,461 -2% reduced
7 RLAY RELAY THERAPEUTICS INC Healthcare 4.1%$263.9m14,106,187 45% added
8 TVTX TRAVERE THERAPEUTICS INC Healthcare 3.3%$213.2m3,752,574 -9% reduced
9 KARD KARDIGAN INC 3.0%$195.6m8,200,662 new
10 NUVALENT INC 3.0%$195.2m1,580,505 0% held
11 EWTX EDGEWISE THERAPEUTICS INC Healthcare 2.8%$177.7m4,373,974 -1% reduced
12 APGE APOGEE THERAPEUTICS INC Healthcare 2.7%$173.6m1,308,113 -15% reduced
13 AMLX AMYLYX PHARMACEUTICALS INC Healthcare 2.3%$149.7m8,334,882 1% added
14 MGTX MEIRAGTX HLDGS PLC Healthcare 2.3%$145.7m10,786,658 4% added
15 ORKA ORUKA THERAPEUTICS INC Healthcare 2.0%$128.0m1,345,063 -4% reduced
16 INBX INHIBRX BIOSCIENCES INC Healthcare 1.9%$123.0m1,297,763 -10% reduced
17 PTGX PROTAGONIST THERAPEUTICS INC Healthcare 1.9%$120.4m981,879 -20% reduced
18 SLDB SOLID BIOSCIENCES INC Healthcare 1.8%$118.9m11,906,646 0% held
19 ZYME ZYMEWORKS INC Healthcare 1.7%$109.3m4,182,953 19% added
20 TNGX TANGO THERAPEUTICS INC Healthcare 1.6%$105.6m3,377,000 318% added
21 IMTX IMMATICS N.V Healthcare 1.6%$105.2m10,383,456 0% held
22 NRIX NURIX THERAPEUTICS INC Healthcare 1.6%$104.8m4,320,422 16% added
23 BCRX BIOCRYST PHARMACEUTICALS INC Healthcare 1.6%$103.1m10,308,888 39% added
24 RVMD REVOLUTION MEDICINES INC Healthcare 1.5%$98.8m527,600 104% added
25 AVALYN PHARMACEUTICALS INC 1.4%$88.1m2,675,296 new
26 DYN DYNE THERAPEUTICS INC Healthcare 0.9%$59.7m2,689,235 -42% reduced
27 BIIB BIOGEN INC Healthcare 0.9%$59.7m276,173 new
28 IMVT IMMUNOVANT INC Healthcare 0.8%$52.3m1,357,383 -15% reduced
29 UNH UNITEDHEALTH GROUP INC Healthcare 0.8%$48.5m116,806 new
30 IONS IONIS PHARMACEUTICALS INC Healthcare 0.7%$44.9m566,000 12% added
31 STRO SUTRO BIOPHARMA INC Healthcare 0.7%$43.3m1,304,846 82% added
32 ANRO ALTO NEUROSCIENCE INC Healthcare 0.7%$42.5m1,609,893 -20% reduced
33 JAZZ JAZZ PHARMACEUTICALS PLC Healthcare 0.6%$41.0m170,000 0% held
34 CRVS CORVUS PHARMACEUTICALS INC Healthcare 0.6%$39.9m2,667,441 16% added
35 SION SIONNA THERAPEUTICS INC Healthcare 0.6%$39.8m905,000 37% added
36 CTMX CYTOMX THERAPEUTICS INC. Healthcare 0.6%$39.1m10,439,185 3% added
37 AORT ARTIVION INC Healthcare 0.6%$39.0m1,737,290 6% added
38 XFOR X4 PHARMACEUTICALS INC 0.6%$37.0m7,933,491 18% added
39 CORT CORCEPT THERAPEUTICS INC Healthcare 0.5%$34.6m398,385 697% added
40 RGEN REPLIGEN CORP Healthcare 0.5%$33.9m248,212 -12% reduced
41 AVR ANTERIS TECHNOLOGIES GLOBAL 0.5%$33.7m3,425,476 0% held
42 RAPP RAPPORT THERAPEUTICS INC 0.5%$32.2m773,342 15% added
43 DMRA DAMORA THERAPEUTICS INC Healthcare 0.5%$31.8m1,223,000 0% held
44 CRL CHARLES RIV LABS INTL INC Healthcare 0.5%$31.8m140,000 new
45 AXSM AXSOME THERAPEUTICS INC. Healthcare 0.5%$29.0m118,450 -21% reduced
46 DBVT DBV TECHNOLOGIES S A 0.4%$27.1m1,653,350 71% added
47 IRTC IRHYTHM HOLDINGS INC Healthcare 0.4%$26.6m223,766 113% added
48 ADPT ADAPTIVE BIOTECHNOLOGIES COR Healthcare 0.4%$26.1m1,217,325 698% added
49 SABS SAB BIOTHERAPEUTICS INC 0.4%$25.8m6,627,501 3% added
50 DHR DANAHER CORP DEL Healthcare 0.4%$24.8m130,000 new

What did Perceptive Advisors LLC sell? Positions exited since the previous filing

StockPrior weightPrior value
ASND ASCENDIS PHARMA A/S47.7%$350.3m
CNTA CENTESSA PHARMACEUTICALS PLC28.5%$208.9m
ENGENE HOLDINGS INC5.4%$39.7m
DAWNGBX DAY ONE BIOPHARMACEUTICALS I5.1%$37.6m
DRUG BRIGHT MINDS BIOSCIENCES INC3.8%$27.5m
BLTE BELITE BIO INC3.3%$24.2m
EVMN EVOMMUNE INC1.4%$10.3m
NMRA NEUMORA THERAPEUTICS INC.1.4%$10.0m
NBIX NEUROCRINE BIOSCIENCES INC1.2%$8.6m
IRD OPUS GENETICS INC1.1%$8.4m
IKT INHIBIKASE THERAPEUTICS INC0.5%$3.9m
APLSUSD APELLIS PHARMACEUTICALS INC0.4%$3.3m
PTN PALATIN TECHNOLOGIES INC0.1%$1.1m

Sector mix

SectorWeight
Healthcare85.9%

Sectors cover positions whose ticker resolved to a sector; the remainder is unclassified, not cash.

Filing history

QuarterPositionsEquity value
Q2 2026102$6.4bn
Q1 202692$5.1bn

How concentrated is Perceptive Advisors LLC's portfolio?

Across every quarter Perceptive Advisors LLC has filed, its median largest position is 11.8% of the book and its median top-ten weight is 50.4%, which WhaleCreep classifies as concentrated (the gate is a median largest position of 5%). Of 12.0 completed holding spells, the median lasted 1.0 quarters; 102.0 positions are still open and their final length is unknown.