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HighVista Strategies LLC: 13F holdings, Q2 2026

Hedge fund · SEC EDGAR filings (CIK 1335325) · Explore on the interactive board

HighVista Strategies LLC disclosed 147 US equity positions worth $438.6m in its Q2 2026 13F filing (holdings as of June 30, 2026, filed August 14, 2026). Its largest position is DBC at 6.4% of the reported book, followed by ABVX, RVMD. The top ten holdings are 28.2% of the book, and the portfolio behaves like about 64 equal-weight positions. Versus the prior filing it opened 29 new positions, added to 50, reduced 64 and exited 25. Note: this manager's most recent filing is 3934 quarters behind the newest quarter on file, so these figures are history rather than current positioning.

This manager's most recent filing is 3934 quarter(s) behind the newest quarter on file. Treat these figures as history, not current positioning.
$438.6mreported US equity book
147positions
6.4%largest position
28.2%top 10 weight
63.89effective positions (1/HHI)
2quarters on file since Q1 2026

What does HighVista Strategies LLC own? Top holdings as of June 30, 2026

Change is measured in shares against the previous filing (Q1 2026), so price moves do not read as decisions. This quarter: 29 new, 50 added, 64 reduced, 25 exited.

#StockSectorWeightValueSharesΔ sharesAction
1 DBC INVESCO DB COMMDY INDX TRCK 6.4%$28.2m1,057,238 0% held
2 ABVX ABIVAX SA Healthcare 3.4%$15.1m113,031 -0% held
3 RVMD REVOLUTION MEDICINES INC Healthcare 2.9%$12.5m66,983 -3% reduced
4 DFTX DEFINIUM THERAPEUTICS INC Healthcare 2.6%$11.4m242,884 31% added
5 IMVT IMMUNOVANT INC Healthcare 2.4%$10.7m277,873 23% added
6 PRAX PRAXIS PRECISION MEDICINES I Healthcare 2.3%$10.1m30,210 15% added
7 RLAY RELAY THERAPEUTICS INC Healthcare 2.2%$9.5m506,235 20% added
8 ALKS ALKERMES PLC Healthcare 2.1%$9.4m179,256 145% added
9 PCVX VAXCYTE INC Healthcare 2.0%$8.7m149,739 20% added
10 TNGX TANGO THERAPEUTICS INC Healthcare 1.9%$8.1m260,070 150% added
11 LQDA LIQUIDIA CORPORATION Healthcare 1.8%$7.8m97,896 -2% reduced
12 COGT COGENT BIOSCIENCES INC Healthcare 1.7%$7.3m188,780 -4% reduced
13 GPCR STRUCTURE THERAPEUTICS INC Healthcare 1.6%$7.0m130,784 6% added
14 ELVN ENLIVEN THERAPEUTICS INC Healthcare 1.6%$7.0m137,866 89% added
15 AMLX AMYLYX PHARMACEUTICALS INC Healthcare 1.6%$6.9m386,080 10% added
16 SYRE SPYRE THERAPEUTICS INC Healthcare 1.6%$6.9m77,807 -47% reduced
17 LB PHARMACEUTICALS INC 1.6%$6.9m211,511 22% added
18 CYTK CYTOKINETICS INC Healthcare 1.5%$6.6m78,003 33% added
19 CCCC C4 THERAPEUTICS INC Healthcare 1.4%$6.3m1,348,136 new
20 TYRA TYRA BIOSCIENCES INC Healthcare 1.3%$5.9m184,774 41% added
21 ALMS ALUMIS INC Healthcare 1.3%$5.6m199,968 77% added
22 PHVS PHARVARIS N V Healthcare 1.3%$5.5m160,494 64% added
23 TARS TARSUS PHARMACEUTICALS INC Healthcare 1.2%$5.5m87,060 66% added
24 CMPS COMPASS PATHWAYS PLC Healthcare 1.2%$5.3m371,120 2% added
25 DNTH DIANTHUS THERAPEUTICS INC Healthcare 1.1%$5.0m51,125 44% added
26 NRIX NURIX THERAPEUTICS INC Healthcare 1.1%$4.9m203,739 -10% reduced
27 AXSM AXSOME THERAPEUTICS INC. Healthcare 1.1%$4.9m20,183 -1% reduced
28 TVTX TRAVERE THERAPEUTICS INC Healthcare 1.1%$4.9m86,233 137% added
29 VERA VERA THERAPEUTICS INC Healthcare 1.0%$4.5m105,907 53% added
30 NVDA NVIDIA CORPORATION Technology 1.0%$4.4m21,792 -3% reduced
31 GHRS GH RESEARCH PLC Healthcare 1.0%$4.3m158,770 -26% reduced
32 PALI PALISADE BIO INC Healthcare 1.0%$4.2m2,030,927 1% added
33 ARGX ARGENX SE Healthcare 1.0%$4.2m4,561 -7% reduced
34 MAZE MAZE THERAPEUTICS INC Healthcare 0.9%$4.1m136,572 37% added
35 OCUL OCULAR THERAPEUTIX INC Healthcare 0.9%$4.0m408,534 -7% reduced
36 ORKA ORUKA THERAPEUTICS INC Healthcare 0.9%$4.0m41,902 -47% reduced
37 DYN DYNE THERAPEUTICS INC Healthcare 0.9%$3.8m171,961 -6% reduced
38 EWTX EDGEWISE THERAPEUTICS INC Healthcare 0.8%$3.7m90,996 -1% reduced
39 MLTX MOONLAKE IMMUNOTHERAPEUTICS Healthcare 0.8%$3.7m187,946 -3% reduced
40 INSM INSMED INC Healthcare 0.8%$3.3m31,256 29% added
41 CLDX CELLDEX THERAPEUTICS INC NEW Healthcare 0.7%$3.2m86,964 -3% reduced
42 AMZN AMAZON COM INC Consumer Cyclical 0.7%$3.2m13,397 -40% reduced
43 IVA INVENTIVA SA 0.7%$3.1m831,442 35% added
44 TLN TALEN ENERGY CORP Utilities 0.7%$3.1m8,148 161% added
45 RLMD RELMADA THERAPEUTICS INC Healthcare 0.7%$3.1m445,799 new
46 PTGX PROTAGONIST THERAPEUTICS INC Healthcare 0.7%$3.0m24,460 -28% reduced
47 ERAS ERASCA INC Healthcare 0.7%$2.9m160,328 -11% reduced
48 VRDN VIRIDIAN THERAPEUTICS INC Healthcare 0.7%$2.9m159,885 19% added
49 HPE HEWLETT PACKARD ENTERPRISE C Technology 0.6%$2.7m59,081 -34% reduced
50 MLYS MINERALYS THERAPEUTICS INC Healthcare 0.5%$2.3m86,085 84% added

What did HighVista Strategies LLC sell? Positions exited since the previous filing

StockPrior weightPrior value
430 TERNS PHARMACEUTICALS INC11.1%$6.0m
NUVALENT INC10.7%$5.8m
SLNOEUR SOLENO THERAPEUTICS INC10.2%$5.5m
APGE APOGEE THERAPEUTICS INC5.6%$3.0m
JAZZ JAZZ PHARMACEUTICALS PLC3.8%$2.0m
NATL NCR ATLEOS CORPORATION3.2%$1.7m
CLH CLEAN HARBORS INC2.9%$1.6m
CRM SALESFORCE INC2.9%$1.6m
XOMA ROYALTY CORPORATION2.7%$1.5m
AVTR AVANTOR INC2.7%$1.5m
ASND ASCENDIS PHARMA A/S2.4%$1.3m
INTU INTUIT2.4%$1.3m
BKNG BOOKING HOLDINGS INC2.2%$1.2m
KRC KILROY REALTY CORP2.2%$1.2m
EQT EQT CORP2.2%$1.2m
PBR/A PETROLEO BRASILEIRO S A2.1%$1.1m
WDAY WORKDAY INC2.0%$1.1m
PTC PTC INC2.0%$1.1m
GEV GE VERNOVA INC2.0%$1.1m
AGX ARGAN INC1.9%$1.0m
AMRZ AMRIZE LTD1.8%$956.1k
RDDT REDDIT INC1.7%$929.1k
MMM 3M CO1.7%$893.2k
UNP UNION PAC CORP1.6%$887.5k
CPNG COUPANG INC1.6%$869.2k

Sector mix

SectorWeight
Healthcare68.5%
Technology8.3%
Industrials5.0%
Financial Services2.5%
Utilities2.1%
Consumer Cyclical1.8%

Sectors cover positions whose ticker resolved to a sector; the remainder is unclassified, not cash.

Filing history

QuarterPositionsEquity value
Q2 2026147$438.6m
Q1 2026156$362.2m

How concentrated is HighVista Strategies LLC's portfolio?

Across every quarter HighVista Strategies LLC has filed, its median largest position is 7.4% of the book and its median top-ten weight is 27.7%, which WhaleCreep classifies as concentrated (the gate is a median largest position of 5%). Of 38.0 completed holding spells, the median lasted 1.0 quarters; 147.0 positions are still open and their final length is unknown.