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Casdin Capital: 13F holdings, Q2 2026

Emerging, concentrated · SEC EDGAR filings (CIK 0001534261) · Explore on the interactive board

Casdin Capital disclosed 43 US equity positions worth $2.0bn in its Q2 2026 13F filing (holdings as of June 30, 2026, filed August 14, 2026). Its largest position is RVMD at 24.2% of the reported book, followed by RLAY, WGS. The top ten holdings are 77.4% of the book, and the portfolio behaves like about 9 equal-weight positions. Versus the prior filing it opened 6 new positions, added to 9, reduced 3 and exited 3.

$2.0bnreported US equity book
43positions
24.2%largest position
77.4%top 10 weight
9.05effective positions (1/HHI)
43quarters on file since Q4 2015

What does Casdin Capital own? Top holdings as of June 30, 2026

Change is measured in shares against the previous filing (Q1 2026), so price moves do not read as decisions. This quarter: 6 new, 9 added, 3 reduced, 3 exited.

#StockSectorWeightValueSharesΔ sharesAction
1 RVMD REVOLUTION MEDICINES INC Healthcare 24.2%$482.7m2,577,333 0% held
2 RLAY RELAY THERAPEUTICS INC Healthcare 15.0%$300.0m16,035,240 11% added
3 WGS GENEDX HOLDINGS CORP Healthcare 12.7%$254.5m3,707,164 23% added
4 BLFS BIOLIFE SOLUTIONS INC Healthcare 6.6%$131.5m4,655,000 -22% reduced
5 ILMN ILLUMINA INC Healthcare 4.7%$93.2m530,000 0% held
6 LAB STANDARD BIOTOOLS INC Healthcare 3.7%$73.0m88,783,856 0% held
7 GPCR STRUCTURE THERAPEUTICS INC Healthcare 3.2%$63.1m1,175,000 0% held
8 DNLI DENALI THERAPEUTICS INC Healthcare 2.6%$52.6m2,045,000 11% added
9 NGNE NEUROGENE INC 2.4%$48.6m1,545,361 9% added
10 BEAM BEAM THERAPEUTICS INC Healthcare 2.3%$46.3m1,350,000 0% held
11 TXG 10X GENOMICS INC Healthcare 2.0%$40.3m1,050,000 -54% reduced
12 SRRK SCHOLAR ROCK HLDG CORP Healthcare 1.8%$36.6m665,000 90% added
13 PSNL PERSONALIS INC Healthcare 1.7%$34.2m2,550,000 59% added
14 GRAL GRAIL INC 1.6%$32.8m480,000 109% added
15 GH GUARDANT HEALTH INC Healthcare 1.4%$27.8m185,000 -41% reduced
16 MAZE MAZE THERAPEUTICS INC 1.3%$25.2m843,857 11% added
17 HIMS HIMS & HERS HEALTH INC Healthcare 1.2%$24.3m700,000 0% held
18 ALNY ALNYLAM PHARMACEUTICALS INC Healthcare 1.1%$22.6m75,000 0% held
19 TSHA TAYSHA GENE THERAPIES INC Healthcare 1.1%$22.1m3,250,000 0% held
20 AGOMAB THERAPEUTICS NV 1.0%$20.1m1,550,000 0% held
21 SEPN SEPTERNA INC 0.9%$18.5m553,268 0% held
22 PARABILIS MEDICINES INC 0.9%$17.7m645,690 new
23 SION SIONNA THERAPEUTICS INC 0.9%$17.6m400,000 new
24 VCYT VERACYTE INC Healthcare 0.8%$16.2m276,308 0% held
25 ANL ADLAI NORTYE LTD 0.7%$14.4m1,250,000 132% added
26 PRME PRIME MEDICINE INC 0.6%$11.7m3,167,175 0% held
27 ABSI ABSCI CORPORATION 0.6%$11.3m973,260 0% held
28 DGX QUEST DIAGNOSTICS INC Healthcare 0.5%$10.6m50,000 0% held
29 SRPT SAREPTA THERAPEUTICS INC Healthcare 0.4%$8.4m470,000 new
30 UNIQURE NV 0.3%$6.9m150,000 new
31 NTLA INTELLIA THERAPEUTICS INC Healthcare 0.3%$6.0m355,000 0% held
32 MRNA MODERNA INC Healthcare 0.3%$5.3m75,000 0% held
33 IRON DISC MEDICINE INC Healthcare 0.2%$4.8m65,000 0% held
34 GLUE MONTE ROSA THERAPEUTICS INC 0.2%$4.5m186,014 0% held
35 IPSC CENTURY THERAPEUTICS INC Healthcare 0.2%$3.0m1,228,190 0% held
36 CTNM CONTINEUM THERAPEUTICS INC 0.1%$2.4m148,333 0% held
37 BRIDGEBIO ONCOLOGY THERAPEUT 0.1%$2.2m282,312 0% held
38 EDIT EDITAS MEDICINE INC Healthcare 0.1%$1.4m445,000 new
39 PACB PACIFIC BIOSCIENCES CALIF IN Healthcare 0.1%$1.2m723,767 0% held
40 KARD KARDIGAN INC 0.1%$1.2m50,000 new
41 RXRX RECURSION PHARMACEUTICALS IN Healthcare 0.0%$606.7k165,323 0% held
42 GINKGO BIOWORKS HOLDINGS INC 0.0%$361.6k36,493 0% held
43 TNYA TENAYA THERAPEUTICS INC 0.0%$267.5k361,969 0% held

What did Casdin Capital sell? Positions exited since the previous filing

StockPrior weightPrior value
QIAGEN NV39.9%$14.4m
TEM TEMPUS AI INC36.8%$13.3m
MLTX MOONLAKE IMMUNOTHERAPEUTICS23.2%$8.4m

Sector mix

SectorWeight
Healthcare88.2%

Sectors cover positions whose ticker resolved to a sector; the remainder is unclassified, not cash.

Filing history

QuarterPositionsEquity value
Q2 202643$2.0bn
Q1 202640$1.3bn
Q4 202538$1.6bn
Q3 202532$1.2bn
Q2 202533$1.1bn
Q1 202544$1.2bn
Q4 202438$1.5bn
Q3 202435$1.5bn
Q2 202438$1.3bn
Q1 202436$1.3bn
Q4 202336$1.0bn
Q3 202338$896.6m
Q2 202341$1.1bn
Q1 202340$1.2bn
Q4 202244$1.3bn
Q3 202236$1.5bn

Earliest filing: Q4 2015 · 43 quarters on file

How concentrated is Casdin Capital's portfolio?

Across every quarter Casdin Capital has filed, its median largest position is 12.9% of the book and its median top-ten weight is 65.0%, which WhaleCreep classifies as concentrated (the gate is a median largest position of 5%). Of 184 completed holding spells, the median lasted 3.0 quarters; 43 positions are still open and their final length is unknown.