WhaleCreep

Casdin Capital, LLC 13F holdings, Q4 2024

Hedge fundSEC filingsCompare with another fundHoldings as of 2024-12-31, filed 2025-02-14

Casdin Capital, LLC disclosed 38 US equity positions worth $1.5bn in its Q4 2024 13F filing. Its largest position is WGS at 18.0% of the reported book, followed by BLFS and RVMD. Versus Q3 2024 it opened 5 new positions, added to 3, reduced 5 and exited 2.

$1.5bn
Reported equity book
Sum of the long US equity positions in the filing, at the values filed. Options are excluded.
38
Positions
Distinct securities in the equity book with a reported value above zero. Options are excluded.
18.0%
Largest position
The largest single position as a share of the reported equity book.
79.2%
Top 10 weight
The ten largest positions together, as a share of the reported equity book.
11
Effective positions
1 / HHI of portfolio weights: the number of equal-weight positions the book behaves like.
43
Quarters on file since Q4 2015
Quarters for which this manager's 13F holdings are on record.

Holdings

Against Q3 2024: 5 new, 3 added, 5 reduced, 2 exited

38 rows
WGS GENEDX HOLDINGS CORPHealthcare18.0%$270m3.51m0.0%held
BLFS BIOLIFE SOLUTIONS INCHealthcare15.1%$226m8.71m0.0%held
RVMD REVOLUTION MEDICINES INCHealthcare10.8%$162m3.70m−10%reduced
SRPT SAREPTA THERAPEUTICS INCHealthcare8.7%$131m1.07m0.0%held
LAB STANDARD BIOTOOLS INCHealthcare8.3%$125m71.25m0.0%held
ILMN ILLUMINA INCHealthcare6.7%$100m750,0000.0%held
RNAGBP AVIDITY BIOSCIENCES INC–4.0%$59.5m2.04m−1.9%reduced
CDXS CODEXIS INCHealthcare2.6%$38.6m8.10m0.0%held
RLAY RELAY THERAPEUTICS INCHealthcare2.5%$36.9m8.95m−3.3%reduced
EXK EXACT SCIENCES CORPBasic Materials2.4%$36.5m650,0000.0%held
ALNY ALNYLAM PHARMACEUTICALS INCHealthcare2.2%$32.9m140,000−18%reduced
BEAM BEAM THERAPEUTICS INCHealthcare2.1%$31.0m1.25m+61%added
NGNE NEUROGENE INCHealthcare2.0%$29.6m1.30m+147%added
2655787D BLUEPRINT MEDICINES CORP–1.9%$28.5m326,3780.0%held
NTLA INTELLIA THERAPEUTICS INCHealthcare1.6%$23.3m2.00m0.0%held
VERVE THERAPEUTICS INC no ticker–1.5%$22.5m4.00m0.0%held
DNLI DENALI THERAPEUTICS INCHealthcare1.3%$20.2m990,0000.0%held
GPCR STRUCTURE THERAPEUTICS INCHealthcare1.3%$19.0m700,0000.0%held
SEPN SEPTERNA INCHealthcare0.8%$12.7m553,268–new
VCYT VERACYTE INCHealthcare0.7%$10.9m276,308−59%reduced
GH GUARDANT HEALTH INCHealthcare0.7%$10.7m350,0000.0%held
TNYA TENAYA THERAPEUTICS INCHealthcare0.6%$9.6m6.73m0.0%held
AGIO AGIOS PHARMACEUTICALS INCHealthcare0.5%$8.2m250,000–new
MRNA MODERNA INCHealthcare0.5%$7.3m175,000–new
FDMT 4D MOLECULAR THERAPEUTICS INHealthcare0.4%$6.4m1.15m0.0%held
SNDX SYNDAX PHARMACEUTICALS INCHealthcare0.4%$6.3m475,0000.0%held
TSVT* 2SEVENTY BIO INC–0.4%$5.9m2.00m0.0%held
IPSC CENTURY THERAPEUTICS INCHealthcare0.4%$5.2m5.19m+62%added
FTRE FORTREA HLDGS INCHealthcare0.3%$5.1m275,000–new
CTNM CONTINEUM THERAPEUTICS INCHealthcare0.3%$4.3m296,6660.0%held
TNGX TANGO THERAPEUTICS INCHealthcare0.2%$3.7m1.19m0.0%held
ABSI ABSCI CORPORATIONHealthcare0.2%$2.5m973,2600.0%held
PACB PACIFIC BIOSCIENCES CALIF INHealthcare0.1%$1.9m1.04m0.0%held
RXRX RECURSION PHARMACEUTICALS INHealthcare0.07%$1.1m165,323–new
PRME PRIME MEDICINE INC–0.07%$1.1m367,1750.0%held
GLUE MONTE ROSA THERAPEUTICS INCHealthcare0.04%$597k86,0140.0%held
DNA GINKGO BIOWORKS HOLDINGS INCHealthcare0.02%$358k36,4930.0%held
KRON1USD KRONOS BIO INC–0.01%$118k123,8390.0%held

Exited since Q3 2024

2 rows
GRAL GRAIL INC0.3%$4.8m
EXAIEUR EXSCIENTIA PLC0.07%$1.0m

Sector mix

  • Healthcare89.7%
  • Unclassified7.9%
  • Basic Materials2.4%

Book over time

Every quarter on file (43)
QuarterPositionsEquity book
Q2 202643$2.0bn
Q1 202640$1.3bn
Q4 202538$1.6bn
Q3 202532$1.2bn
Q2 202533$1.1bn
Q1 202544$1.2bn
Q4 202438$1.5bn
Q3 202435$1.5bn
Q2 202438$1.3bn
Q1 202436$1.3bn
Q4 202336$1.0bn
Q3 202338$897m
Q2 202341$1.1bn
Q1 202340$1.2bn
Q4 202244$1.3bn
Q3 202236$1.5bn
Q2 202240$1.2bn
Q1 202247$2.2bn
Q4 202153$3.5bn
Q3 202153$4.0bn
Q2 202154$3.9bn
Q1 202148$3.4bn
Q4 202050$3.4bn
Q3 202045$2.2bn
Q2 202042$1.7bn
Q1 202038$942m
Q4 201931$1.1bn
Q3 201933$966m
Q2 201931$1.1bn
Q1 201929$910m
Q4 201831$585m
Q3 201834$814m
Q2 201832$709m
Q1 201830$565m
Q4 201726$409m
Q3 201726$354m
Q2 201731$250m
Q1 201729$170m
Q4 201625$121m
Q3 201626$123m
Q2 201624$95.7m
Q1 201625$84.5m
Q4 201527$107m

Where Casdin Capital, LLC was early

41 rows
EDIT EDITAS MEDICINE INCQ1 20162 of 963.5%3.5%15Held at last filing, Q2 2026−91%
ONC BEIGENE LTDQ1 20169 of 1041.1%2.1%16Exited by Q2 2025+829%
EVH EVOLENT HEALTH INCQ2 20161 of 1304.8%7.7%12Exited by Q2 2019−34%
T8S TESARO INCQ2 20168 of 831.8%2.7%4Exited by Q4 2017+54%
MDRX ALLSCRIPTS HEALTHCARE SOLUTNQ3 20168 of 962.1%2.4%3Exited by Q2 2017−3.7%
CDXS CODEXIS INCQ1 20172 of 801.9%8.1%29Exited by Q3 2025−49%
PACB PACIFIC BIOSCIENCES CALIF INQ1 20173 of 1182.1%5.1%21Held at last filing, Q2 2026−68%
SGMOQ SANGAMO THERAPEUTICS INCQ1 20173 of 852.6%5.9%19Exited by Q3 2022−20%
FATE FATE THERAPEUTICS INCQ2 20174 of 1070.7%8.3%27Exited by Q1 2024+15%
CRSP CRISPR THERAPEUTICS AGQ1 20181 of 1201.1%1.8%11Exited by Q1 2022+66%
ZLAB ZAI LAB LTDQ1 20186 of 990.5%1.0%11Exited by Q2 2022+106%
BLFS BIOLIFE SOLUTIONS INCQ2 20181 of 781.6%16.3%33Held at last filing, Q2 2026+148%
CDNA CAREDX INCQ2 20186 of 1030.3%3.0%16Exited by Q2 2022+202%
CNST CONSTELLATION PHARMCETICLS IQ3 20181 of 721.1%5.3%12Exited by Q3 2021–
2JQ GRITSTONE ONCOLOGY INCQ3 20182 of 621.3%1.9%8Exited by Q3 2020−53%
SRPT SAREPTA THERAPEUTICS INCQ3 201814 of 1820.8%13.7%29Held at last filing, Q2 2026−89%
DNLI DENALI THERAPEUTICS INCQ4 20182 of 1040.4%3.7%31Held at last filing, Q2 2026+24%
ALEC ALECTOR INCQ1 20194 of 870.7%2.8%12Exited by Q1 2022+10%
TWST TWIST BIOSCIENCE CORPQ2 20192 of 990.8%4.2%17Exited by Q3 2023−29%
ADPT ADAPTIVE BIOTECHNOLOGIES CORQ2 20194 of 1301.9%2.3%12Exited by Q2 2022−71%
FULC FULCRUM THERAPEUTICS INCQ3 20191 of 950.6%1.9%8Exited by Q3 2021+58%
RVMD REVOLUTION MEDICINES INCQ1 20201 of 1643.1%24.2%26Held at last filing, Q2 2026+755%
DMTKQ DERMTECH INCQ1 20202 of 470.6%2.6%9Exited by Q2 2022+31%
ALLO ALLOGENE THERAPEUTICS INCQ1 20204 of 941.0%1.6%8Exited by Q1 2022−23%
GBIOGBX GENERATION BIO COQ2 20201 of 482.0%2.2%8Exited by Q2 2022−65%
RLAY RELAY THERAPEUTICS INCQ3 20201 of 1117.3%15.0%24Held at last filing, Q2 2026−56%
FDMT 4D MOLECULAR THERAPEUTICS INQ4 20201 of 941.0%2.1%16Exited by Q1 2025−87%
BEAM BEAM THERAPEUTICS INCQ4 20203 of 981.1%3.2%23Held at last filing, Q2 2026−58%
ABCL ABCELLERA BIOLOGICS INCQ4 20207 of 870.2%1.8%9Exited by Q2 2024−89%
IPSC CENTURY THERAPEUTICS INCQ2 20213 of 512.4%2.4%21Held at last filing, Q2 2026−92%
TNYA TENAYA THERAPEUTICS INCQ3 20211 of 531.8%3.3%20Held at last filing, Q2 2026−96%
ABSI ABSCI CORPORATIONQ3 20212 of 762.2%2.9%20Held at last filing, Q2 2026−0.3%
MXCT MAXCYTE INCQ3 20212 of 634.3%5.6%9Exited by Q4 2023−74%
TNGX TANGO THERAPEUTICS INCQ3 20212 of 1031.8%1.9%13Exited by Q2 2025−89%
WGS GENEDX HOLDINGS CORPQ3 20215 of 1040.9%29.5%20Held at last filing, Q2 2026−73%
TSVT* 2SEVENTY BIO INCQ1 20224 of 700.5%1.8%13Exited by Q2 2025−71%
PLRX PLIANT THERAPEUTICS INCQ3 20228 of 1031.0%3.7%8Exited by Q3 2024−49%
PRME PRIME MEDICINE INCQ4 20223 of 621.1%1.5%15Held at last filing, Q2 2026−80%
GPCR STRUCTURE THERAPEUTICS INCQ1 20231 of 1141.3%6.9%14Held at last filing, Q2 2026+126%
NGNE NEUROGENE INCQ4 20232 of 451.0%2.4%11Held at last filing, Q2 2026+62%
MAZE MAZE THERAPEUTICS INCQ1 20259 of 820.9%2.0%6Held at last filing, Q2 2026+171%

Concentration and tenure

12.9%
Median largest position, all quarters
The largest single position as a share of the reported equity book.
65.0%
Median top 10 weight, all quarters
The ten largest positions together, as a share of the reported equity book.
Concentrated
Style, by median largest position
3
Median completed holding, quarters