WhaleCreep

Casdin Capital, LLC 13F holdings, Q1 2026

Hedge fundSEC filingsCompare with another fundHoldings as of 2026-03-31, filed 2026-05-15

Casdin Capital, LLC disclosed 40 US equity positions worth $1.3bn in its Q1 2026 13F filing. Its largest position is RVMD at 19.0% of the reported book, followed by WGS and RLAY. Versus Q4 2025 it opened 9 new positions, added to 7, reduced 4 and exited 7.

$1.3bn
Reported equity book
Sum of the long US equity positions in the filing, at the values filed. Options are excluded.
40
Positions
Distinct securities in the equity book with a reported value above zero. Options are excluded.
19.0%
Largest position
The largest single position as a share of the reported equity book.
77.3%
Top 10 weight
The ten largest positions together, as a share of the reported equity book.
11
Effective positions
1 / HHI of portfolio weights: the number of equal-weight positions the book behaves like.
43
Quarters on file since Q4 2015
Quarters for which this manager's 13F holdings are on record.

Holdings

Against Q4 2025: 9 new, 7 added, 4 reduced, 7 exited

40 rows
RVMD REVOLUTION MEDICINES INCHealthcare19.0%$251m2.58m0.0%held
WGS GENEDX HOLDINGS CORPHealthcare14.6%$193m3.01m0.0%held
RLAY RELAY THERAPEUTICS INCHealthcare10.9%$143m14.42m+11%added
BLFS BIOLIFE SOLUTIONS INCHealthcare8.6%$114m5.96m0.0%held
LAB STANDARD BIOTOOLS INCHealthcare6.2%$81.6m88.78m0.0%held
ILMN ILLUMINA INCHealthcare4.9%$65.3m530,000−12%reduced
GPCR STRUCTURE THERAPEUTICS INCHealthcare4.3%$56.6m1.18m0.0%held
TXG 10X GENOMICS INCHealthcare3.7%$48.3m2.27m+63%added
DNLI DENALI THERAPEUTICS INCHealthcare2.7%$35.3m1.84m0.0%held
BEAM BEAM THERAPEUTICS INCHealthcare2.4%$32.2m1.35m−16%reduced
GH GUARDANT HEALTH INCHealthcare2.2%$29.1m315,000−17%reduced
NGNE NEUROGENE INCHealthcare2.2%$28.6m1.42m+9.6%added
ALNY ALNYLAM PHARMACEUTICALS INCHealthcare1.9%$24.8m75,0000.0%held
MAZE MAZE THERAPEUTICS INCHealthcare1.7%$22.7m758,8570.0%held
SRRK SCHOLAR ROCK HLDG CORPHealthcare1.3%$17.2m350,000+35%added
AGOMAB THERAPEUTICS NV no ticker–1.2%$16.3m1.55m–new
HIMS HIMS & HERS HEALTH INCHealthcare1.1%$14.5m700,000+82%added
TSHA TAYSHA GENE THERAPIES INCHealthcare1.1%$14.5m3.25m+117%added
QGEN QIAGEN NVHealthcare1.1%$14.4m360,000–new
TEM TEMPUS AI INCHealthcare1.0%$13.3m294,1270.0%held
SEPN SEPTERNA INCHealthcare1.0%$13.3m553,2680.0%held
GRAL GRAIL INCHealthcare0.9%$11.9m230,000–new
PRME PRIME MEDICINE INC–0.8%$11.0m3.17m0.0%held
PSNL PERSONALIS INCHealthcare0.8%$10.2m1.60m–new
DGX QUEST DIAGNOSTICS INCHealthcare0.7%$9.8m50,0000.0%held
VCYT VERACYTE INCHealthcare0.7%$8.9m276,3080.0%held
MLTX MOONLAKE IMMUNOTHERAPEUTICSHealthcare0.6%$8.4m450,000–new
NTLA INTELLIA THERAPEUTICS INCHealthcare0.3%$4.6m355,000–new
IRON DISC MEDICINE INCHealthcare0.3%$4.2m65,000–new
MRNA MODERNA INCHealthcare0.3%$3.8m75,000–new
ANL ADLAI NORTYE LTD–0.3%$3.7m538,461–new
GLUE MONTE ROSA THERAPEUTICS INCHealthcare0.2%$3.1m186,014+116%added
ABSI ABSCI CORPORATIONHealthcare0.2%$2.9m973,2600.0%held
IPSC CENTURY THERAPEUTICS INCHealthcare0.2%$2.8m1.23m0.0%held
BBOT BRIDGEBIO ONCOLOGY THERAPEUTHealthcare0.2%$2.5m282,3120.0%held
CTNM CONTINEUM THERAPEUTICS INCHealthcare0.1%$1.9m148,3330.0%held
PACB PACIFIC BIOSCIENCES CALIF INHealthcare0.07%$955k723,767−83%reduced
RXRX RECURSION PHARMACEUTICALS INHealthcare0.04%$508k165,3230.0%held
TNYA TENAYA THERAPEUTICS INCHealthcare0.02%$251k361,9690.0%held
DNA GINKGO BIOWORKS HOLDINGS INCHealthcare0.02%$224k36,4930.0%held

Exited since Q4 2025

7 rows
RNAGBP AVIDITY BIOSCIENCES INC4.5%$72.1m
SPRY ARS PHARMACEUTICALS INC1.2%$18.6m
UNH UNITEDHEALTH GROUP INC1.0%$16.5m
DXCM DEXCOM INC0.7%$11.6m
CI THE CIGNA GROUP0.7%$11.0m
INCY INCYTE CORP0.6%$9.9m
LEGN LEGEND BIOTECH CORP0.3%$4.7m

Sector mix

  • Healthcare97.7%
  • Unclassified2.3%

Book over time

Every quarter on file (43)
QuarterPositionsEquity book
Q2 202643$2.0bn
Q1 202640$1.3bn
Q4 202538$1.6bn
Q3 202532$1.2bn
Q2 202533$1.1bn
Q1 202544$1.2bn
Q4 202438$1.5bn
Q3 202435$1.5bn
Q2 202438$1.3bn
Q1 202436$1.3bn
Q4 202336$1.0bn
Q3 202338$897m
Q2 202341$1.1bn
Q1 202340$1.2bn
Q4 202244$1.3bn
Q3 202236$1.5bn
Q2 202240$1.2bn
Q1 202247$2.2bn
Q4 202153$3.5bn
Q3 202153$4.0bn
Q2 202154$3.9bn
Q1 202148$3.4bn
Q4 202050$3.4bn
Q3 202045$2.2bn
Q2 202042$1.7bn
Q1 202038$942m
Q4 201931$1.1bn
Q3 201933$966m
Q2 201931$1.1bn
Q1 201929$910m
Q4 201831$585m
Q3 201834$814m
Q2 201832$709m
Q1 201830$565m
Q4 201726$409m
Q3 201726$354m
Q2 201731$250m
Q1 201729$170m
Q4 201625$121m
Q3 201626$123m
Q2 201624$95.7m
Q1 201625$84.5m
Q4 201527$107m

Where Casdin Capital, LLC was early

41 rows
EDIT EDITAS MEDICINE INCQ1 20162 of 963.5%3.5%15Held at last filing, Q2 2026−91%
ONC BEIGENE LTDQ1 20169 of 1041.1%2.1%16Exited by Q2 2025+829%
EVH EVOLENT HEALTH INCQ2 20161 of 1304.8%7.7%12Exited by Q2 2019−34%
T8S TESARO INCQ2 20168 of 831.8%2.7%4Exited by Q4 2017+54%
MDRX ALLSCRIPTS HEALTHCARE SOLUTNQ3 20168 of 962.1%2.4%3Exited by Q2 2017−3.7%
CDXS CODEXIS INCQ1 20172 of 801.9%8.1%29Exited by Q3 2025−49%
PACB PACIFIC BIOSCIENCES CALIF INQ1 20173 of 1182.1%5.1%21Held at last filing, Q2 2026−68%
SGMOQ SANGAMO THERAPEUTICS INCQ1 20173 of 852.6%5.9%19Exited by Q3 2022−20%
FATE FATE THERAPEUTICS INCQ2 20174 of 1070.7%8.3%27Exited by Q1 2024+15%
CRSP CRISPR THERAPEUTICS AGQ1 20181 of 1201.1%1.8%11Exited by Q1 2022+66%
ZLAB ZAI LAB LTDQ1 20186 of 990.5%1.0%11Exited by Q2 2022+106%
BLFS BIOLIFE SOLUTIONS INCQ2 20181 of 781.6%16.3%33Held at last filing, Q2 2026+148%
CDNA CAREDX INCQ2 20186 of 1030.3%3.0%16Exited by Q2 2022+202%
CNST CONSTELLATION PHARMCETICLS IQ3 20181 of 721.1%5.3%12Exited by Q3 2021–
2JQ GRITSTONE ONCOLOGY INCQ3 20182 of 621.3%1.9%8Exited by Q3 2020−53%
SRPT SAREPTA THERAPEUTICS INCQ3 201814 of 1820.8%13.7%29Held at last filing, Q2 2026−89%
DNLI DENALI THERAPEUTICS INCQ4 20182 of 1040.4%3.7%31Held at last filing, Q2 2026+24%
ALEC ALECTOR INCQ1 20194 of 870.7%2.8%12Exited by Q1 2022+10%
TWST TWIST BIOSCIENCE CORPQ2 20192 of 990.8%4.2%17Exited by Q3 2023−29%
ADPT ADAPTIVE BIOTECHNOLOGIES CORQ2 20194 of 1301.9%2.3%12Exited by Q2 2022−71%
FULC FULCRUM THERAPEUTICS INCQ3 20191 of 950.6%1.9%8Exited by Q3 2021+58%
RVMD REVOLUTION MEDICINES INCQ1 20201 of 1643.1%24.2%26Held at last filing, Q2 2026+755%
DMTKQ DERMTECH INCQ1 20202 of 470.6%2.6%9Exited by Q2 2022+31%
ALLO ALLOGENE THERAPEUTICS INCQ1 20204 of 941.0%1.6%8Exited by Q1 2022−23%
GBIOGBX GENERATION BIO COQ2 20201 of 482.0%2.2%8Exited by Q2 2022−65%
RLAY RELAY THERAPEUTICS INCQ3 20201 of 1117.3%15.0%24Held at last filing, Q2 2026−56%
FDMT 4D MOLECULAR THERAPEUTICS INQ4 20201 of 941.0%2.1%16Exited by Q1 2025−87%
BEAM BEAM THERAPEUTICS INCQ4 20203 of 981.1%3.2%23Held at last filing, Q2 2026−58%
ABCL ABCELLERA BIOLOGICS INCQ4 20207 of 870.2%1.8%9Exited by Q2 2024−89%
IPSC CENTURY THERAPEUTICS INCQ2 20213 of 512.4%2.4%21Held at last filing, Q2 2026−92%
TNYA TENAYA THERAPEUTICS INCQ3 20211 of 531.8%3.3%20Held at last filing, Q2 2026−96%
ABSI ABSCI CORPORATIONQ3 20212 of 762.2%2.9%20Held at last filing, Q2 2026−0.3%
MXCT MAXCYTE INCQ3 20212 of 634.3%5.6%9Exited by Q4 2023−74%
TNGX TANGO THERAPEUTICS INCQ3 20212 of 1031.8%1.9%13Exited by Q2 2025−89%
WGS GENEDX HOLDINGS CORPQ3 20215 of 1040.9%29.5%20Held at last filing, Q2 2026−73%
TSVT* 2SEVENTY BIO INCQ1 20224 of 700.5%1.8%13Exited by Q2 2025−71%
PLRX PLIANT THERAPEUTICS INCQ3 20228 of 1031.0%3.7%8Exited by Q3 2024−49%
PRME PRIME MEDICINE INCQ4 20223 of 621.1%1.5%15Held at last filing, Q2 2026−80%
GPCR STRUCTURE THERAPEUTICS INCQ1 20231 of 1141.3%6.9%14Held at last filing, Q2 2026+126%
NGNE NEUROGENE INCQ4 20232 of 451.0%2.4%11Held at last filing, Q2 2026+62%
MAZE MAZE THERAPEUTICS INCQ1 20259 of 820.9%2.0%6Held at last filing, Q2 2026+171%

Concentration and tenure

12.9%
Median largest position, all quarters
The largest single position as a share of the reported equity book.
65.0%
Median top 10 weight, all quarters
The ten largest positions together, as a share of the reported equity book.
Concentrated
Style, by median largest position
3
Median completed holding, quarters