WhaleCreep

Casdin Capital, LLC 13F holdings, Q2 2025

Hedge fundSEC filingsCompare with another fundHoldings as of 2025-06-30, filed 2025-08-14

Casdin Capital, LLC disclosed 33 US equity positions worth $1.1bn in its Q2 2025 13F filing. Its largest position is WGS at 29.5% of the reported book, followed by BLFS and RVMD. Versus Q1 2025 it opened 1 new position, added to 9, reduced 12 and exited 12.

$1.1bn
Reported equity book
Sum of the long US equity positions in the filing, at the values filed. Options are excluded.
33
Positions
Distinct securities in the equity book with a reported value above zero. Options are excluded.
29.5%
Largest position
The largest single position as a share of the reported equity book.
85.3%
Top 10 weight
The ten largest positions together, as a share of the reported equity book.
7
Effective positions
1 / HHI of portfolio weights: the number of equal-weight positions the book behaves like.
43
Quarters on file since Q4 2015
Quarters for which this manager's 13F holdings are on record.

Holdings

Against Q1 2025: 1 new, 9 added, 12 reduced, 12 exited

33 rows
WGS GENEDX HOLDINGS CORPHealthcare29.5%$324m3.51m0.0%held
BLFS BIOLIFE SOLUTIONS INCHealthcare15.1%$166m7.71m−11%reduced
RVMD REVOLUTION MEDICINES INCHealthcare9.7%$106m2.89m−22%reduced
LAB STANDARD BIOTOOLS INCHealthcare8.3%$91.3m76.08m0.0%held
ILMN ILLUMINA INCHealthcare5.6%$61.5m645,000+8.4%added
RNAGBP AVIDITY BIOSCIENCES INC–4.6%$50.4m1.77m−13%reduced
VERVE THERAPEUTICS INC no ticker–4.2%$46.0m4.10m+2.5%added
RLAY RELAY THERAPEUTICS INCHealthcare3.6%$39.4m11.40m+25%added
ALNY ALNYLAM PHARMACEUTICALS INCHealthcare2.4%$26.6m81,500−32%reduced
GPCR STRUCTURE THERAPEUTICS INCHealthcare2.3%$25.4m1.23m+75%added
BEAM BEAM THERAPEUTICS INCHealthcare2.2%$24.7m1.45m+1.7%added
NGNE NEUROGENE INCHealthcare1.8%$19.4m1.30m0.0%held
CDXS CODEXIS INCHealthcare1.6%$17.6m7.20m−11%reduced
SRPT SAREPTA THERAPEUTICS INCHealthcare1.5%$16.9m990,097+9.9%added
DNLI DENALI THERAPEUTICS INCHealthcare1.1%$12.5m890,000−10%reduced
HIMS HIMS & HERS HEALTH INCHealthcare1.0%$11.5m230,000+15%added
MAZE MAZE THERAPEUTICS INCHealthcare0.8%$9.3m758,857−20%reduced
VCYT VERACYTE INCHealthcare0.7%$7.5m276,3080.0%held
LLY ELI LILLY & COHealthcare0.6%$6.6m8,500–new
SNDX SYNDAX PHARMACEUTICALS INCHealthcare0.6%$6.1m650,000+2.4%added
SEPN SEPTERNA INCHealthcare0.5%$5.8m553,2680.0%held
GH GUARDANT HEALTH INCHealthcare0.5%$5.2m100,000−60%reduced
EXK EXACT SCIENCES CORPBasic Materials0.4%$4.8m90,000−78%reduced
PRME PRIME MEDICINE INC–0.4%$3.9m1.57m+327%added
AGIO AGIOS PHARMACEUTICALS INCHealthcare0.3%$3.3m100,000−60%reduced
ABSI ABSCI CORPORATIONHealthcare0.2%$2.5m973,2600.0%held
PACB PACIFIC BIOSCIENCES CALIF INHealthcare0.08%$897k723,7670.0%held
RXRX RECURSION PHARMACEUTICALS INHealthcare0.08%$837k165,3230.0%held
IPSC CENTURY THERAPEUTICS INCHealthcare0.06%$686k1.23m−62%reduced
CTNM CONTINEUM THERAPEUTICS INCHealthcare0.05%$589k148,3330.0%held
DNA GINKGO BIOWORKS HOLDINGS INCHealthcare0.04%$411k36,4930.0%held
GLUE MONTE ROSA THERAPEUTICS INCHealthcare0.04%$388k86,0140.0%held
TNYA TENAYA THERAPEUTICS INCHealthcare0.02%$221k361,969−95%reduced

Exited since Q1 2025

12 rows
2655787D BLUEPRINT MEDICINES CORP2.4%$28.9m
NTLA INTELLIA THERAPEUTICS INC1.2%$14.2m
ONC BEIGENE LTD0.9%$10.9m
TSVT* 2SEVENTY BIO INC0.8%$9.9m
GEHC GE HEALTHCARE TECHNOLOGIES I0.7%$8.1m
MRNA MODERNA INC0.5%$6.4m
VSTM VERASTEM INC0.3%$3.6m
SLDB SOLID BIOSCIENCES INC0.2%$2.9m
TDOC TELADOC HEALTH INC0.2%$2.4m
DYN DYNE THERAPEUTICS INC0.09%$1.0m
TNGX TANGO THERAPEUTICS INC0.01%$171k
KRON1USD KRONOS BIO INC0.01%$102k

Sector mix

  • Healthcare90.4%
  • Unclassified9.1%
  • Basic Materials0.4%

Book over time

Every quarter on file (43)
QuarterPositionsEquity book
Q2 202643$2.0bn
Q1 202640$1.3bn
Q4 202538$1.6bn
Q3 202532$1.2bn
Q2 202533$1.1bn
Q1 202544$1.2bn
Q4 202438$1.5bn
Q3 202435$1.5bn
Q2 202438$1.3bn
Q1 202436$1.3bn
Q4 202336$1.0bn
Q3 202338$897m
Q2 202341$1.1bn
Q1 202340$1.2bn
Q4 202244$1.3bn
Q3 202236$1.5bn
Q2 202240$1.2bn
Q1 202247$2.2bn
Q4 202153$3.5bn
Q3 202153$4.0bn
Q2 202154$3.9bn
Q1 202148$3.4bn
Q4 202050$3.4bn
Q3 202045$2.2bn
Q2 202042$1.7bn
Q1 202038$942m
Q4 201931$1.1bn
Q3 201933$966m
Q2 201931$1.1bn
Q1 201929$910m
Q4 201831$585m
Q3 201834$814m
Q2 201832$709m
Q1 201830$565m
Q4 201726$409m
Q3 201726$354m
Q2 201731$250m
Q1 201729$170m
Q4 201625$121m
Q3 201626$123m
Q2 201624$95.7m
Q1 201625$84.5m
Q4 201527$107m

Where Casdin Capital, LLC was early

41 rows
EDIT EDITAS MEDICINE INCQ1 20162 of 963.5%3.5%15Held at last filing, Q2 2026−91%
ONC BEIGENE LTDQ1 20169 of 1041.1%2.1%16Exited by Q2 2025+829%
EVH EVOLENT HEALTH INCQ2 20161 of 1304.8%7.7%12Exited by Q2 2019−34%
T8S TESARO INCQ2 20168 of 831.8%2.7%4Exited by Q4 2017+54%
MDRX ALLSCRIPTS HEALTHCARE SOLUTNQ3 20168 of 962.1%2.4%3Exited by Q2 2017−3.7%
CDXS CODEXIS INCQ1 20172 of 801.9%8.1%29Exited by Q3 2025−49%
PACB PACIFIC BIOSCIENCES CALIF INQ1 20173 of 1182.1%5.1%21Held at last filing, Q2 2026−68%
SGMOQ SANGAMO THERAPEUTICS INCQ1 20173 of 852.6%5.9%19Exited by Q3 2022−20%
FATE FATE THERAPEUTICS INCQ2 20174 of 1070.7%8.3%27Exited by Q1 2024+15%
CRSP CRISPR THERAPEUTICS AGQ1 20181 of 1201.1%1.8%11Exited by Q1 2022+66%
ZLAB ZAI LAB LTDQ1 20186 of 990.5%1.0%11Exited by Q2 2022+106%
BLFS BIOLIFE SOLUTIONS INCQ2 20181 of 781.6%16.3%33Held at last filing, Q2 2026+148%
CDNA CAREDX INCQ2 20186 of 1030.3%3.0%16Exited by Q2 2022+202%
CNST CONSTELLATION PHARMCETICLS IQ3 20181 of 721.1%5.3%12Exited by Q3 2021–
2JQ GRITSTONE ONCOLOGY INCQ3 20182 of 621.3%1.9%8Exited by Q3 2020−53%
SRPT SAREPTA THERAPEUTICS INCQ3 201814 of 1820.8%13.7%29Held at last filing, Q2 2026−89%
DNLI DENALI THERAPEUTICS INCQ4 20182 of 1040.4%3.7%31Held at last filing, Q2 2026+24%
ALEC ALECTOR INCQ1 20194 of 870.7%2.8%12Exited by Q1 2022+10%
TWST TWIST BIOSCIENCE CORPQ2 20192 of 990.8%4.2%17Exited by Q3 2023−29%
ADPT ADAPTIVE BIOTECHNOLOGIES CORQ2 20194 of 1301.9%2.3%12Exited by Q2 2022−71%
FULC FULCRUM THERAPEUTICS INCQ3 20191 of 950.6%1.9%8Exited by Q3 2021+58%
RVMD REVOLUTION MEDICINES INCQ1 20201 of 1643.1%24.2%26Held at last filing, Q2 2026+755%
DMTKQ DERMTECH INCQ1 20202 of 470.6%2.6%9Exited by Q2 2022+31%
ALLO ALLOGENE THERAPEUTICS INCQ1 20204 of 941.0%1.6%8Exited by Q1 2022−23%
GBIOGBX GENERATION BIO COQ2 20201 of 482.0%2.2%8Exited by Q2 2022−65%
RLAY RELAY THERAPEUTICS INCQ3 20201 of 1117.3%15.0%24Held at last filing, Q2 2026−56%
FDMT 4D MOLECULAR THERAPEUTICS INQ4 20201 of 941.0%2.1%16Exited by Q1 2025−87%
BEAM BEAM THERAPEUTICS INCQ4 20203 of 981.1%3.2%23Held at last filing, Q2 2026−58%
ABCL ABCELLERA BIOLOGICS INCQ4 20207 of 870.2%1.8%9Exited by Q2 2024−89%
IPSC CENTURY THERAPEUTICS INCQ2 20213 of 512.4%2.4%21Held at last filing, Q2 2026−92%
TNYA TENAYA THERAPEUTICS INCQ3 20211 of 531.8%3.3%20Held at last filing, Q2 2026−96%
ABSI ABSCI CORPORATIONQ3 20212 of 762.2%2.9%20Held at last filing, Q2 2026−0.3%
MXCT MAXCYTE INCQ3 20212 of 634.3%5.6%9Exited by Q4 2023−74%
TNGX TANGO THERAPEUTICS INCQ3 20212 of 1031.8%1.9%13Exited by Q2 2025−89%
WGS GENEDX HOLDINGS CORPQ3 20215 of 1040.9%29.5%20Held at last filing, Q2 2026−73%
TSVT* 2SEVENTY BIO INCQ1 20224 of 700.5%1.8%13Exited by Q2 2025−71%
PLRX PLIANT THERAPEUTICS INCQ3 20228 of 1031.0%3.7%8Exited by Q3 2024−49%
PRME PRIME MEDICINE INCQ4 20223 of 621.1%1.5%15Held at last filing, Q2 2026−80%
GPCR STRUCTURE THERAPEUTICS INCQ1 20231 of 1141.3%6.9%14Held at last filing, Q2 2026+126%
NGNE NEUROGENE INCQ4 20232 of 451.0%2.4%11Held at last filing, Q2 2026+62%
MAZE MAZE THERAPEUTICS INCQ1 20259 of 820.9%2.0%6Held at last filing, Q2 2026+171%

Concentration and tenure

12.9%
Median largest position, all quarters
The largest single position as a share of the reported equity book.
65.0%
Median top 10 weight, all quarters
The ten largest positions together, as a share of the reported equity book.
Concentrated
Style, by median largest position
3
Median completed holding, quarters