| Krensavage Asset Management, LLC Hedge fund | 14.3% | $37.5m | 69,282 | −18% | reduced |
| Avoro Capital Advisors LLC Hedge fund | 13.5% | $1.5bn | 2.78m | +5.6% | added |
| Diadema Partners LP Hedge fund | 10.1% | $28.7m | 52,989 | +94% | added |
| Eversept Partners, LP Hedge fund | 8.5% | $156m | 287,668 | +8.9% | added |
| Vestal Point Capital, LP Hedge fund | 5.5% | $236m | 435,000 | +480% | added |
| Palo Alto Investors LP Hedge fund | 4.7% | $33.9m | 62,587 | −0.4% | held |
| Soleus Capital Management, L.P. Hedge fund | 4.2% | $122m | 225,587 | +21% | added |
| Summit Street Capital Management, LLC Hedge fund | 4.0% | $28.6m | 52,789 | −7.2% | reduced |
| Tri Locum Partners LP Hedge fund | 3.1% | $25.5m | 47,026 | −33% | reduced |
| Deerfield Management Company, L.P. Hedge fund | 2.6% | $248m | 457,000 | 0.0% | held |
| Superstring Capital Management LP Hedge fund | 2.5% | $3.9m | 7,172 | +38% | added |
| Persistent Asset Partners Ltd Hedge fund | 2.4% | $7.6m | 13,981 | +103% | added |
| PFM Health Sciences, LP Hedge fund | 2.4% | $27.1m | 49,991 | +26% | added |
| Crawford Fund Management, LLC Hedge fund | 2.2% | $7.2m | 13,368 | −10% | reduced |
| Sofinnova Investments, Inc. Hedge fund | 2.2% | $41.4m | 76,489 | −52% | reduced |
| Elmind Capital, LP Hedge fund | 2.0% | $8.1m | 15,000 | 0.0% | held |
| KVP Capital Advisors, LP Hedge fund | 1.9% | $2.6m | 4,750 | 0.0% | held |
| Exome Asset Management LLC Hedge fund | 1.8% | $2.9m | 5,410 | −23% | reduced |
| Ardsley Advisory Partners LP Hedge fund | 1.8% | $16.3m | 30,000 | −40% | reduced |
| Tobam Hedge fund | 1.4% | $5.9m | 10,875 | +22% | added |
| Mork Capital Management, LLC Hedge fund | 1.4% | $2.2m | 4,100 | 0.0% | held |
| Renaissance Technologies LLC Hedge fund | 1.3% | $926m | 1.71m | −4.4% | reduced |
| Birchview Capital, LP Hedge fund | 1.1% | $2.4m | 4,506 | +0.1% | held |
| Formula Growth Ltd Hedge fund | 1.0% | $2.9m | 5,334 | −0.4% | held |
| Deep Track Capital, LP Hedge fund | 1.0% | $67.0m | 123,616 | – | new |
| Twinbeech Capital LP Hedge fund | 0.6% | $3.2m | 5,854 | – | new |
| Artia Global Partners LP Hedge fund | 0.5% | $2.7m | 5,000 | 0.0% | held |
| Campbell & CO Investment Adviser LLC Hedge fund | 0.4% | $7.2m | 13,309 | +107% | added |
| Atom Investors LP Hedge fund | 0.3% | $3.3m | 6,052 | −46% | reduced |
| HighVista Strategies LLC Hedge fund | 0.3% | $1.1m | 2,095 | +38% | added |
| Lecap Asset Management Ltd Hedge fund | 0.3% | $595k | 1,099 | +13% | added |
| Axiom Investors LLC Hedge fund | 0.3% | $29.5m | 54,437 | +6662% | added |
| AlphaGrep UK Ltd Hedge fund | 0.3% | $836k | 1,543 | +229% | added |
| Bridgewater Associates, LP Hedge fund | 0.2% | $60.3m | 111,326 | +0.1% | held |
| Baillie Gifford Long-only investor | 0.2% | $253m | 467,209 | +9.1% | added |
| Capital Fund Management S.A. Hedge fund | 0.2% | $28.7m | 53,037 | +8.3% | added |
| Aquatic Capital Management LLC Hedge fund | 0.2% | $5.5m | 10,212 | – | new |
| Caption Management, LLC Hedge fund | 0.2% | $5.1m | 9,333 | −87% | reduced |
| Point72 Asset Management, L.P. Hedge fund | 0.2% | $109m | 201,159 | +35% | added |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. Hedge fund | 0.2% | $561k | 1,035 | +96% | added |
| Y-Intercept (Hong Kong) Ltd Hedge fund | 0.2% | $7.7m | 14,271 | – | new |
| Millennium Management LLC Hedge fund | 0.1% | $222m | 409,074 | +167% | added |
| Edgestream Partners, L.P. Hedge fund | 0.1% | $5.0m | 9,178 | – | new |
| Qube Research & Technologies Ltd Hedge fund | 0.1% | $127m | 233,639 | +89% | added |
| Candriam S.C.A. Hedge fund | 0.1% | $29.1m | 53,684 | −15% | reduced |
| Oxford Asset Management LLP Hedge fund | 0.1% | $234k | 432 | – | new |
| Dymon Asia Capital (Singapore) Pte. Ltd. Hedge fund | 0.1% | $683k | 1,260 | −14% | reduced |
| Quantitative Investment Management, LLC Hedge fund | 0.1% | $992k | 1,831 | – | new |
| O'Connor Alternative Investments LLC Hedge fund | 0.1% | $1.5m | 2,700 | – | new |
| DG Capital Management, LLC Hedge fund | 0.1% | $302k | 558 | 0.0% | held |
| AQR Capital Management LLC Hedge fund | 0.1% | $295m | 546,002 | −34% | reduced |
| Citadel Advisors LLC Hedge fund | 0.09% | $165m | 304,692 | −16% | reduced |
| 111 Capital Hedge fund | 0.08% | $487k | 898 | – | new |
| West Family Investments, Inc. Family office | 0.08% | $287k | 530 | +14% | added |
| Machina Capital S.A.S. Hedge fund | 0.08% | $492k | 908 | −59% | reduced |
| Voleon Capital Management LP Hedge fund | 0.08% | $4.1m | 7,649 | +146% | added |
| Rokos Capital Management LLP Hedge fund | 0.07% | $5.8m | 10,634 | – | new |
| Partners Capital Investment Group, LLP Hedge fund | 0.06% | $1.7m | 3,120 | −15% | reduced |
| Lighthouse Investment Partners, LLC Hedge fund | 0.06% | $1.9m | 3,446 | – | new |
| Squarepoint Ops LLC Hedge fund | 0.05% | $26.4m | 48,656 | – | new |
| Qsemble Capital Management, LP Hedge fund | 0.05% | $364k | 671 | −36% | reduced |
| Catalyst Funds Management Pty Ltd Hedge fund | 0.04% | $781k | 1,441 | – | new |
| Woodline Partners LP Hedge fund | 0.04% | $12.5m | 23,074 | +564% | added |
| IFM Investors Pty Ltd Hedge fund | 0.03% | $5.2m | 9,675 | +9.0% | added |
| Engineers Gate Manager LP Hedge fund | 0.03% | $2.5m | 4,658 | – | new |
| Brevan Howard Capital Management LP Hedge fund | 0.03% | $2.3m | 4,174 | – | new |
| Tudor Investment Corp ET AL Hedge fund | 0.03% | $6.9m | 12,667 | – | new |
| BTG Pactual Asset Management US LLC Hedge fund | 0.03% | $366k | 675 | – | new |
| Prelude Capital Management, LLC Hedge fund | 0.02% | $299k | 551 | −77% | reduced |
| Arrowstreet Capital, Limited Partnership Hedge fund | 0.02% | $45.4m | 83,855 | – | new |
| Schonfeld Strategic Advisors LLC Hedge fund | 0.02% | $3.4m | 6,201 | +45% | added |
| Verition Fund Management LLC Hedge fund | 0.01% | $2.0m | 3,675 | – | new |
| Weiss Asset Management LP Hedge fund | 0.01% | $1.2m | 2,281 | – | new |
| Marshall Wace, LLP Hedge fund | 0.01% | $16.4m | 30,231 | −60% | reduced |
| Hudson Bay Capital Management LP Hedge fund | 0.01% | $2.7m | 5,000 | −76% | reduced |
| Trexquant Investment LP Hedge fund | 0.01% | $2.0m | 3,668 | – | new |
| Jain Global LLC Hedge fund | 0.01% | $703k | 1,298 | – | new |
| Boothbay Fund Management, LLC Hedge fund | 0.01% | $424k | 782 | – | new |
| ExodusPoint Capital Management, LP Hedge fund | 0.01% | $745k | 1,375 | – | new |
| Two Sigma Investments, LP Hedge fund | 0.01% | $6.8m | 12,606 | −55% | reduced |
| Freestone Grove Partners LP Hedge fund | 0.0% | $654k | 1,207 | −33% | reduced |
| Capstone Investment Advisors, LLC Hedge fund | 0.0% | $608k | 1,123 | +4.7% | added |
| CVA Family Office, LLC Family office | 0.0% | $36.3k | 67 | 0.0% | held |
| Balyasny Asset Management L.P. Hedge fund | 0.0% | $1.3m | 2,307 | −94% | reduced |
| Holocene Advisors, LP Hedge fund | 0.0% | $845k | 1,559 | 0.0% | held |
| Quarry LP Hedge fund | 0.0% | $1.6k | 3 | – | new |