| Sarissa Capital Management LP Hedge fund | 10.9% | $19.5m | 228,623 | 0.0% | held |
| Checkpoint Capital L.P. Hedge fund | 10.4% | $40.5m | 475,000 | +164% | added |
| Melqart Asset Management (UK) Ltd Hedge fund | 6.2% | $65.4m | 767,525 | −9.1% | reduced |
| Integral Health Asset Management, LLC Hedge fund | 5.6% | $136m | 1.60m | 0.0% | held |
| Trails Edge Capital Partners, LP Hedge fund | 3.9% | $24.5m | 288,089 | −4.0% | reduced |
| Avoro Capital Advisors LLC Hedge fund | 3.8% | $426m | 5.00m | +50% | added |
| Exome Asset Management LLC Hedge fund | 3.2% | $5.1m | 60,056 | −42% | reduced |
| Armistice Capital, LLC Hedge fund | 2.8% | $102m | 1.20m | +57% | added |
| DAFNA Capital Management LLC Hedge fund | 2.8% | $14.7m | 171,998 | −21% | reduced |
| Sphera Funds Management Ltd. Hedge fund | 2.7% | $18.7m | 219,987 | +452% | added |
| ACT Capital Management, LLC Hedge fund | 2.6% | $4.0m | 47,500 | −26% | reduced |
| Affinity Asset Advisors, LLC Hedge fund | 2.3% | $46.9m | 550,000 | −21% | reduced |
| Frazier Life Sciences Management, L.P. Hedge fund | 2.2% | $98.8m | 1.16m | 0.0% | held |
| RTW Investments, LP Hedge fund | 2.1% | $244m | 2.86m | +5.2% | added |
| Ishara Investments LP Hedge fund | 2.1% | $2.8m | 32,800 | – | new |
| Tri Locum Partners LP Hedge fund | 2.0% | $16.5m | 194,000 | – | new |
| ADAR1 Capital Management, LLC Hedge fund | 1.8% | $39.0m | 457,907 | −28% | reduced |
| Kingdon Capital Management, L.L.C. Hedge fund | 1.8% | $13.4m | 157,100 | – | new |
| Seven Fleet Capital Management LP Hedge fund | 1.7% | $10.1m | 118,240 | +93% | added |
| HighVista Strategies LLC Hedge fund | 1.5% | $6.6m | 78,003 | +33% | added |
| PFM Health Sciences, LP Hedge fund | 1.4% | $16.3m | 191,686 | – | new |
| Polymer Capital Management (HK) LTD Hedge fund | 1.2% | $11.8m | 138,255 | – | new |
| Birchview Capital, LP Hedge fund | 1.2% | $2.6m | 30,000 | 0.0% | held |
| Artia Global Partners LP Hedge fund | 1.1% | $6.0m | 70,700 | +334% | added |
| Stempoint Capital LP Hedge fund | 1.1% | $6.4m | 75,603 | −42% | reduced |
| Encore Global Management, LP Hedge fund | 1.1% | $1.1m | 12,731 | +155% | added |
| Militia Capital Management LLC Hedge fund | 0.9% | $5.1m | 60,000 | – | new |
| Deep Track Capital, LP Hedge fund | 0.9% | $59.6m | 700,000 | −49% | reduced |
| Rock Springs Capital Management LP Hedge fund | 0.8% | $16.0m | 187,980 | +314% | added |
| Boxer Capital Management, LLC Hedge fund | 0.6% | $8.5m | 100,000 | 0.0% | held |
| Capricorn Fund Managers Ltd Hedge fund | 0.6% | $7.0m | 81,879 | – | new |
| Polar Capital Holdings Plc Hedge fund | 0.5% | $192m | 2.25m | +36% | added |
| Cinctive Capital Management LP Hedge fund | 0.5% | $11.7m | 137,838 | +293% | added |
| Palo Alto Investors LP Hedge fund | 0.4% | $2.7m | 32,195 | 0.0% | held |
| Aquatic Capital Management LLC Hedge fund | 0.4% | $10.7m | 125,090 | +73% | added |
| Burkehill Global Management, LP Hedge fund | 0.3% | $8.5m | 100,000 | – | new |
| Campbell & CO Investment Adviser LLC Hedge fund | 0.3% | $5.6m | 65,978 | – | new |
| Seven Grand Managers, LLC Hedge fund | 0.3% | $7.2m | 85,000 | – | new |
| Woodline Partners LP Hedge fund | 0.3% | $93.8m | 1.10m | +10% | added |
| Ghisallo Capital Management LLC Hedge fund | 0.3% | $14.5m | 170,000 | – | new |
| SummitTX Capital, L.P. Hedge fund | 0.3% | $9.6m | 112,893 | +127% | added |
| Holocene Advisors, LP Hedge fund | 0.2% | $97.5m | 1.14m | – | new |
| Balyasny Asset Management L.P. Hedge fund | 0.2% | $121m | 36.36m | −0.8% | reduced |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. Hedge fund | 0.2% | $753k | 8,836 | +20% | added |
| Point72 Asset Management, L.P. Hedge fund | 0.2% | $135m | 1.59m | +154% | added |
| Dark Forest Capital Management LP Hedge fund | 0.2% | $3.1m | 36,708 | +117% | added |
| ExodusPoint Capital Management, LP Hedge fund | 0.2% | $21.2m | 249,259 | +377% | added |
| ABS Investment Management LLC Hedge fund | 0.2% | $273k | 85 | – | |
| Candriam S.C.A. Hedge fund | 0.2% | $37.7m | 443,066 | +32% | added |
| Bayforest Capital Ltd Hedge fund | 0.2% | $183k | 2,143 | +96% | added |
| Carlson Capital, L.P. Hedge fund | 0.2% | $767k | 9,000 | 0.0% | held |
| Persistent Asset Partners Ltd Hedge fund | 0.1% | $455k | 5,346 | – | new |
| Landscape Capital Management, L.L.C. Hedge fund | 0.1% | $2.1m | 24,734 | – | new |
| GABELLI & Co INVESTMENT ADVISERS, INC. Hedge fund | 0.1% | $897k | 10,528 | −22% | reduced |
| Oxford Asset Management LLP Hedge fund | 0.1% | $242k | 2,836 | – | new |
| Boothbay Fund Management, LLC Hedge fund | 0.1% | $5.8m | 68,092 | −35% | reduced |
| Walleye Capital LLC Hedge fund | 0.10% | $20.4m | 239,728 | – | new |
| Panoramic Capital, LLC Hedge fund | 0.09% | $213k | 2,500 | – | new |
| Baker Bros. Advisors LP Hedge fund | 0.09% | $18.0m | 211,267 | – | new |
| AlphaGrep UK Ltd Hedge fund | 0.09% | $285k | 3,343 | – | new |
| Wolverine Asset Management LLC Hedge fund | 0.07% | $5.7m | 3.33m | +2774067% | added |
| Y-Intercept (Hong Kong) Ltd Hedge fund | 0.07% | $3.7m | 43,619 | – | new |
| Freestone Grove Partners LP Hedge fund | 0.06% | $9.8m | 114,824 | −47% | reduced |
| FNY Investment Advisers, LLC Hedge fund | 0.06% | $170k | 2,000 | −78% | reduced |
| Trexquant Investment LP Hedge fund | 0.06% | $9.8m | 115,134 | +139% | added |
| Capstone Investment Advisors, LLC Hedge fund | 0.06% | $8.5m | 5.00m | 0.0% | held |
| D. E. Shaw & Co., Inc. Hedge fund | 0.06% | $89.3m | 1.05m | +48% | added |
| Alyeska Investment Group, L.P. Hedge fund | 0.05% | $21.3m | 250,000 | +67% | added |
| Quarry LP Hedge fund | 0.05% | $346k | 4,058 | – | new |
| Qube Research & Technologies Ltd Hedge fund | 0.05% | $48.8m | 572,535 | −27% | reduced |
| J. Goldman & Co LP Hedge fund | 0.05% | $1.5m | 18,002 | +50% | added |
| Moore Capital Management, LP Hedge fund | 0.05% | $2.1m | 25,000 | 0.0% | held |
| Context Capital Management, LLC Hedge fund | 0.05% | $2.4m | 1.39m | 0.0% | held |
| Orbimed Advisors LLC Hedge fund | 0.04% | $2.2m | 25,800 | – | new |
| Two Sigma Investments, LP Hedge fund | 0.04% | $53.8m | 16.09m | +14% | added |
| Verition Fund Management LLC Hedge fund | 0.03% | $4.7m | 54,889 | – | new |
| Tudor Investment Corp ET AL Hedge fund | 0.03% | $7.9m | 92,680 | – | new |
| CenterBook Partners LP Hedge fund | 0.03% | $661k | 7,759 | −1.3% | reduced |
| Marshall Wace, LLP Hedge fund | 0.03% | $38.5m | 451,467 | −31% | reduced |
| Citadel Advisors LLC Hedge fund | 0.03% | $54.6m | 640,945 | −42% | reduced |
| Centiva Capital, LP Hedge fund | 0.03% | $821k | 9,643 | +221% | added |
| Schonfeld Strategic Advisors LLC Hedge fund | 0.02% | $4.5m | 53,354 | −47% | reduced |
| Quinn Opportunity Partners LLC Hedge fund | 0.02% | $426k | 5,000 | −69% | reduced |
| Brevan Howard Capital Management LP Hedge fund | 0.01% | $1.0m | 11,891 | −76% | reduced |
| Hudson Bay Capital Management LP Hedge fund | 0.01% | $2.6m | 30,000 | −24% | reduced |
| Quantbot Technologies LP Hedge fund | 0.01% | $255k | 2,991 | – | new |
| Millennium Management LLC Hedge fund | 0.01% | $9.3m | 109,717 | +12% | added |
| AQR Capital Management LLC Hedge fund | 0.0% | $13.8m | 161,903 | +3.4% | added |
| Magnetar Financial LLC Hedge fund | 0.0% | $241k | 2,829 | – | new |
| Squarepoint Ops LLC Hedge fund | 0.0% | $226k | 2,655 | – | new |
| CVA Family Office, LLC Family office | 0.0% | $3.7k | 43 | +126% | added |