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Vestal Point Capital, LP 13F holdings, Q4 2025

Holdings as of December 31, 2025 · filings on SEC EDGAR · latest filing →

Vestal Point Capital, LP disclosed 75 US equity positions worth $2.7bn in its Q4 2025 13F filing. The largest position was ABVX at 9.4% of the reported book, followed by ACLXGBX and 430. Against the Q3 2025 filing, it opened 12 new positions, added to 21 and reduced 14 among the top 50 holdings.

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What did Vestal Point Capital, LP own in Q4 2025? Top 50 positions

#StockSectorWeightValueSharesΔ sharesvs Q3 2025
1 ABVX Abivax SA 9.4%$256.2m1,900,000 90% added
2 ACLXGBX Arcellx Inc 7.0%$190.7m2,925,000 134% added
3 430 Terns Pharmaceuticals Inc 6.7%$181.8m4,500,000 – new
4 BMRN BioMarin Pharmaceutical Inc Healthcare 6.5%$178.3m3,000,000 261% added
5 GMED Globus Medical Inc Healthcare 4.1%$111.3m1,275,000 2% added
6 NRIX Nurix Therapeutics Inc Healthcare 3.3%$89.0m4,690,000 35% added
7 ALC Alcon AG Healthcare 3.2%$87.1m1,105,000 0% held
8 DXCM Dexcom Inc Healthcare 3.1%$84.6m1,275,000 96% added
9 MRK Merck & Co Inc Healthcare 3.0%$81.6m775,000 – new
10 TSHA Taysha Gene Therapies Inc Healthcare 2.8%$75.6m13,750,000 150% added
11 ABT Abbott Laboratories Healthcare 2.8%$75.2m600,000 140% added
12 IMTX Immatics NV Healthcare 2.4%$64.3m6,125,000 -4% reduced
13 TYRA Tyra Biosciences Inc Healthcare 2.3%$63.8m2,425,000 0% held
14 BCAX Bicara Therapeutics Inc 2.2%$60.2m3,575,000 -30% reduced
15 ARWR Arrowhead Pharmaceuticals Inc Healthcare 2.2%$59.8m900,000 – new
16 ELVN Enliven Therapeutics Inc Healthcare 2.2%$59.0m3,830,000 230% added
17 IRON Disc Medicine Inc Healthcare 2.1%$58.4m735,000 47% added
18 JAZZ Jazz Pharmaceuticals PLC Healthcare 1.8%$49.3m290,000 -42% reduced
19 DAWNGBX Day One Biopharmaceuticals Inc 1.8%$48.5m5,200,000 94% added
20 LXEO Lexeo Therapeutics Inc Healthcare 1.6%$44.4m4,475,000 38% added
21 ANRO Alto Neuroscience Inc Healthcare 1.6%$44.2m2,485,000 162% added
22 APGE Apogee Therapeutics Inc Healthcare 1.5%$41.5m550,000 29% added
23 OLMA Olema Pharmaceuticals Inc Healthcare 1.5%$41.2m1,650,000 – new
24 AXSM Axsome Therapeutics Inc Healthcare 1.4%$38.4m210,000 40% added
25 ASND Ascendis Pharma A/S Healthcare 1.4%$37.3m175,000 -71% reduced
26 RAPP Rapport Therapeutics Inc 1.2%$33.7m1,110,000 17% added
27 SLDB Solid Biosciences Inc Healthcare 1.2%$32.8m5,815,000 95% added
28 CLDX Celldex Therapeutics Inc Healthcare 1.2%$31.6m1,165,000 -3% reduced
29 SRRK Scholar Rock Holding Corp Healthcare 1.1%$30.8m700,000 -53% reduced
30 4XC1 KalVista Pharmaceuticals Inc 1.1%$30.5m1,890,000 152% added
31 VERA Vera Therapeutics Inc Healthcare 1.0%$27.9m550,000 -28% reduced
32 XENE Xenon Pharmaceuticals Inc Healthcare 1.0%$26.9m600,000 -45% reduced
33 LNTH Lantheus Holdings Inc Healthcare 0.9%$24.0m360,000 112% added
34 RVMD Revolution Medicines Inc Healthcare 0.9%$23.5m295,000 -53% reduced
35 ZYME Zymeworks Inc Healthcare 0.8%$22.8m865,000 -51% reduced
36 IMCR Immunocore Holdings PLC Healthcare 0.7%$20.3m585,000 – new
37 UPB Upstream Bio Inc 0.7%$19.5m720,000 – new
38 BBNX Beta Bionics Inc Healthcare 0.7%$18.3m600,000 0% held
39 CBIO Crescent Biopharma Inc 0.7%$17.8m1,500,000 – new
40 BCRX BioCryst Pharmaceuticals Inc Healthcare 0.6%$17.6m2,250,000 – new
41 PEN Penumbra Inc Healthcare 0.6%$15.5m50,000 – new
42 GERN Geron Corp Healthcare 0.5%$14.9m11,320,000 -34% reduced
43 RGEN Repligen Corp Healthcare 0.5%$13.6m83,000 -79% reduced
44 ZBH Zimmer Biomet Holdings Inc Healthcare 0.5%$13.5m150,000 – new
45 BMY Bristol-Myers Squibb Co Healthcare 0.5%$13.5m250,000 – new
46 GLUE Monte Rosa Therapeutics Inc 0.4%$12.2m775,000 -3% reduced
47 FULC Fulcrum Therapeutics Inc Healthcare 0.4%$10.7m950,000 – new
48 SVRA Savara Inc Healthcare 0.4%$9.7m1,606,000 -60% reduced
49 Engene Holdings Inc 0.3%$9.5m1,055,000 185% added
50 AGIO Agios Pharmaceuticals Inc Healthcare 0.3%$8.8m325,000 156% added

Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.