| Krensavage Asset Management, LLC Hedge fund | 6.9% | $18.1m | 200,000 | +3900% | added |
| Southeastern Asset Management (Mason Hawkins) Long-only investor | 4.0% | $76.3m | 840,747 | – | new |
| Defilade Capital Management, L.P. Hedge fund | 3.5% | $25.9m | 285,778 | – | new |
| Vestal Point Capital, LP Hedge fund | 3.0% | $127m | 1.40m | – | new |
| Ilex Capital Partners (UK) LLP Hedge fund | 2.0% | $98.2m | 1.08m | – | new |
| Sio Capital Management, LLC Hedge fund | 2.0% | $11.7m | 128,656 | −31% | reduced |
| Sivik Global Healthcare LLC Hedge fund | 1.9% | $2.6m | 25,000 | 0.0% | held |
| Integral Health Asset Management, LLC Hedge fund | 1.5% | $36.3m | 400,000 | – | new |
| One River Asset Management, LLC Hedge fund | 1.1% | $223k | 2,456 | +11% | added |
| Machina Capital S.A.S. Hedge fund | 1.0% | $6.0m | 66,250 | +83% | added |
| iSAM Funds (UK) Ltd Hedge fund | 0.9% | $1.3m | 14,800 | – | new |
| ClearAlpha Technologies LP Hedge fund | 0.9% | $549k | 6,049 | +49% | added |
| Qsemble Capital Management, LP Hedge fund | 0.9% | $7.2m | 79,172 | −0.6% | reduced |
| Alpha Wealth Funds, LLC Hedge fund | 0.9% | $1.5m | 16,120 | +126% | added |
| Alpine Woods Capital Investors, LLC Hedge fund | 0.9% | $3.9m | 43,202 | +1199% | added |
| Freestone Grove Partners LP Hedge fund | 0.8% | $125m | 1.37m | – | new |
| Hudson Bay Capital Management LP Hedge fund | 0.7% | $145m | 1.60m | +2033% | added |
| New Vernon Investment Management LLC Hedge fund | 0.7% | $537k | 5,918 | 0.0% | held |
| PFM Health Sciences, LP Hedge fund | 0.6% | $7.5m | 82,230 | −41% | reduced |
| Sofinnova Investments, Inc. Hedge fund | 0.6% | $11.2m | 122,998 | – | new |
| Fulcrum Asset Management LLP Hedge fund | 0.6% | $5.9m | 63,409 | – | new |
| Sone Capital Management, LLC Hedge fund | 0.6% | $7.6m | 83,673 | +109% | added |
| Two Sigma Investments, LP Hedge fund | 0.6% | $737m | 8.13m | +27% | added |
| Holocene Advisors, LP Hedge fund | 0.5% | $226m | 2.49m | +215% | added |
| Okabena Investment Services Inc Hedge fund | 0.5% | $2.8m | 31,209 | −0.3% | held |
| Citadel Advisors LLC Hedge fund | 0.4% | $780m | 8.60m | +349% | added |
| Arrowstreet Capital, Limited Partnership Hedge fund | 0.4% | $989m | 10.90m | +97% | added |
| Marshall Wace, LLP Hedge fund | 0.4% | $503m | 5.54m | +176% | added |
| Atom Investors LP Hedge fund | 0.4% | $4.6m | 50,174 | +140% | added |
| Aquatic Capital Management LLC Hedge fund | 0.4% | $11.5m | 127,090 | −53% | reduced |
| Entropy Technologies, LP Hedge fund | 0.4% | $9.6m | 105,540 | −39% | reduced |
| Meridiem Capital Partners LP Hedge fund | 0.4% | $8.0m | 88,519 | – | new |
| Lecap Asset Management Ltd Hedge fund | 0.4% | $848k | 9,341 | +2.2% | added |
| Cinctive Capital Management LP Hedge fund | 0.4% | $8.9m | 97,812 | – | new |
| Occudo Quantitative Strategies LP Hedge fund | 0.3% | $6.3m | 68,918 | −49% | reduced |
| Jupiter Asset Management Ltd Hedge fund | 0.3% | $66.3m | 719,148 | −6.2% | reduced |
| Arlington Partners LLC Hedge fund | 0.3% | $177k | 1,953 | −14% | reduced |
| Adage Capital Partners GP, L.L.C. Hedge fund | 0.3% | $212m | 2.33m | +37% | added |
| Capital Fund Management S.A. Hedge fund | 0.3% | $39.8m | 438,231 | +637% | added |
| Alyeska Investment Group, L.P. Hedge fund | 0.3% | $107m | 1.18m | – | new |
| Tudor Investment Corp ET AL Hedge fund | 0.3% | $66.3m | 730,332 | +124% | added |
| IFM Investors Pty Ltd Hedge fund | 0.2% | $37.1m | 408,377 | +7.7% | added |
| Fox Run Management, L.L.C. Hedge fund | 0.2% | $1.4m | 15,229 | −9.6% | reduced |
| Millennium Management LLC Hedge fund | 0.2% | $327m | 3.60m | +172% | added |
| Qube Research & Technologies Ltd Hedge fund | 0.2% | $194m | 2.14m | +540% | added |
| Point72 Asset Management, L.P. Hedge fund | 0.2% | $141m | 1.55m | – | new |
| West Family Investments, Inc. Family office | 0.2% | $735k | 8,104 | +286% | added |
| Woodline Partners LP Hedge fund | 0.2% | $59.9m | 660,517 | +131% | added |
| Ninety One North America, Inc. Hedge fund | 0.2% | $3.7m | 40,884 | −18% | reduced |
| Catalyst Funds Management Pty Ltd Hedge fund | 0.2% | $2.9m | 32,301 | – | new |
| Edgestream Partners, L.P. Hedge fund | 0.2% | $5.5m | 60,361 | +1426% | added |
| Lowe Brockenbrough & Co Inc Hedge fund | 0.2% | $3.6m | 39,850 | −3.1% | reduced |
| Squarepoint Ops LLC Hedge fund | 0.2% | $78.8m | 867,886 | +118% | added |
| Avidity Partners Management LP Hedge fund | 0.1% | $907k | 10,000 | – | new |
| Walleye Capital LLC Hedge fund | 0.1% | $29.9m | 329,761 | −19% | reduced |
| Persistent Asset Partners Ltd Hedge fund | 0.1% | $433k | 4,770 | −30% | reduced |
| AQR Capital Management LLC Hedge fund | 0.1% | $380m | 4.19m | +167% | added |
| Pin Oak Investment Advisors Inc Hedge fund | 0.1% | $183k | 2,014 | −4.8% | reduced |
| Campbell & CO Investment Adviser LLC Hedge fund | 0.1% | $2.5m | 27,012 | −28% | reduced |
| Cohen Klingenstein LLC Hedge fund | 0.1% | $4.5m | 49,435 | 0.0% | held |
| Montanova Capital, LLC Hedge fund | 0.1% | $6.1m | 66,920 | 0.0% | held |
| Balyasny Asset Management L.P. Hedge fund | 0.1% | $67.2m | 740,808 | −12% | reduced |
| Tobam Hedge fund | 0.1% | $502k | 5,531 | – | new |
| Twinbeech Capital LP Hedge fund | 0.1% | $664k | 7,315 | −25% | reduced |
| Quantbot Technologies LP Hedge fund | 0.1% | $2.9m | 31,964 | −72% | reduced |
| Trust Asset Management LLC Hedge fund | 0.1% | $1.8m | 19,373 | +0.5% | added |
| O'Connor Alternative Investments LLC Hedge fund | 0.1% | $1.5m | 16,500 | – | new |
| Element Capital Management LLC Hedge fund | 0.1% | $2.0m | 21,500 | – | new |
| Kintegral Advisory, LLC Hedge fund | 0.1% | $1.3m | 13,873 | 0.0% | held |
| ExodusPoint Capital Management, LP Hedge fund | 0.09% | $10.0m | 109,826 | – | new |
| Candriam S.C.A. Hedge fund | 0.09% | $19.1m | 211,167 | −66% | reduced |
| Renaissance Technologies LLC Hedge fund | 0.09% | $62.3m | 686,366 | −45% | reduced |
| D. E. Shaw & Co., Inc. Hedge fund | 0.08% | $132m | 1.46m | −72% | reduced |
| Armistice Capital, LLC Hedge fund | 0.06% | $2.0m | 22,381 | – | new |
| Soros Fund Management Family office | 0.05% | $4.1m | 44,750 | 0.0% | held |
| Lighthouse Investment Partners, LLC Hedge fund | 0.05% | $1.6m | 17,786 | – | new |
| CVA Family Office, LLC Family office | 0.05% | $526k | 5,795 | −14% | reduced |
| Caption Management, LLC Hedge fund | 0.04% | $1.1m | 12,000 | – | new |
| SummitTX Capital, L.P. Hedge fund | 0.04% | $1.3m | 14,787 | – | new |
| Capstone Investment Advisors, LLC Hedge fund | 0.03% | $4.6m | 51,072 | −36% | reduced |
| Cercano Management LLC Hedge fund | 0.03% | $237k | 2,607 | 0.0% | held |
| Gsa Capital Partners LLP Hedge fund | 0.03% | $406k | 4,477 | −90% | reduced |
| First Manhattan Long-only investor | 0.02% | $9.8m | 107,475 | −8.2% | reduced |
| Port Capital LLC Hedge fund | 0.02% | $562k | 6,199 | +1.7% | added |
| Bridgewater Associates, LP Hedge fund | 0.02% | $5.4m | 59,775 | −49% | reduced |
| Schonfeld Strategic Advisors LLC Hedge fund | 0.02% | $3.9m | 42,828 | – | new |
| Hillsdale Investment Management Inc. Hedge fund | 0.02% | $826k | 9,100 | −13% | reduced |
| Trexquant Investment LP Hedge fund | 0.02% | $3.0m | 33,177 | – | new |
| Gardner Russo & Quinn (Tom Russo) Long-only investor | 0.01% | $1.0m | 11,510 | 0.0% | held |
| Brevan Howard Capital Management LP Hedge fund | 0.01% | $764k | 8,416 | −47% | reduced |
| Verition Fund Management LLC Hedge fund | 0.01% | $1.5m | 16,392 | +50% | added |
| Voleon Capital Management LP Hedge fund | 0.01% | $570k | 6,286 | −75% | reduced |
| Horizon Kinetics (Murray Stahl) Long-only investor | 0.01% | $882k | 9,716 | +1.6% | added |
| Boothbay Fund Management, LLC Hedge fund | 0.01% | $477k | 5,256 | −82% | reduced |
| Readystate Asset Management LP Hedge fund | 0.01% | $210k | 2,319 | – | new |
| Wolverine Asset Management LLC Hedge fund | 0.01% | $475k | 5,237 | −1.0% | reduced |
| Engineers Gate Manager LP Hedge fund | 0.01% | $453k | 4,990 | −97% | reduced |
| Polen Capital Long-only investor | 0.0% | $286k | 3,156 | −79% | reduced |
| Quarry LP Hedge fund | 0.0% | $5.4k | 60 | 0.0% | held |