| Kite Lake Capital Management (UK) LLP Hedge fund | 14.2% | $40.1m | 300,600 | +201% | added |
| Artia Global Partners LP Hedge fund | 13.1% | $68.8m | 516,447 | −14% | reduced |
| Creek Drive Management Group LLC Hedge fund | 13.0% | $21.0m | 157,500 | +1.6% | added |
| Octagon Capital Advisors LP Hedge fund | 12.1% | $132m | 993,000 | +47% | added |
| ADAR1 Capital Management, LLC Hedge fund | 11.3% | $240m | 1.80m | +29% | added |
| Helikon Investments Ltd Hedge fund | 11.1% | $371m | 2.79m | +175% | added |
| Caligan Partners LP Hedge fund | 10.0% | $208m | 1.56m | +6.6% | added |
| Saturn V Capital Management LP Hedge fund | 9.9% | $69.1m | 518,865 | −4.4% | reduced |
| Darwin Global Management, Ltd. Hedge fund | 9.3% | $348m | 3.62m | +4.4% | added |
| Western Standard LLC Hedge fund | 9.0% | $26.7m | 200,000 | – | new |
| ACT Capital Management, LLC Hedge fund | 8.4% | $12.9m | 97,000 | +37% | added |
| Diadema Partners LP Hedge fund | 7.6% | $21.6m | 163,644 | +115% | added |
| Vestal Point Capital, LP Hedge fund | 7.3% | $313m | 2.35m | +57% | added |
| Ikarian Capital, LLC Hedge fund | 7.1% | $43.4m | 328,635 | +470% | added |
| Eversept Partners, LP Hedge fund | 6.6% | $122m | 913,880 | −2.2% | reduced |
| Stempoint Capital LP Hedge fund | 6.5% | $37.8m | 283,657 | −9.6% | reduced |
| Great Point Partners LLC Hedge fund | 6.4% | $27.2m | 204,314 | – | new |
| Boxer Capital Management, LLC Hedge fund | 6.1% | $80.6m | 605,000 | +203% | added |
| Logos Global Management LP Hedge fund | 5.9% | $136m | 1.02m | +52% | added |
| DG Capital Management, LLC Hedge fund | 5.6% | $16.3m | 122,267 | – | new |
| Cormorant Asset Management, LP Hedge fund | 4.6% | $90.0m | 675,000 | −11% | reduced |
| Findell Capital Management LLC Hedge fund | 4.1% | $24.7m | 185,000 | +76% | added |
| Melqart Asset Management (UK) Ltd Hedge fund | 3.9% | $40.9m | 307,250 | – | new |
| Exome Asset Management LLC Hedge fund | 3.9% | $6.2m | 46,878 | – | new |
| HighVista Strategies LLC Hedge fund | 3.4% | $15.1m | 113,031 | −0.2% | held |
| MPM Bioimpact LLC Hedge fund | 2.7% | $44.8m | 336,347 | +214% | added |
| Silverarc Capital Management, LLC Hedge fund | 2.5% | $22.6m | 169,593 | −44% | reduced |
| Prosight Management, LP Hedge fund | 2.5% | $14.3m | 107,394 | +2.3% | added |
| Seven Fleet Capital Management LP Hedge fund | 2.4% | $14.8m | 111,334 | +159% | added |
| Affinity Asset Advisors, LLC Hedge fund | 2.2% | $44.0m | 330,000 | −19% | reduced |
| Cannon Global Investment Management, LLC Hedge fund | 2.1% | $706k | 5,300 | −12% | reduced |
| Persistent Asset Partners Ltd Hedge fund | 1.9% | $5.9m | 44,256 | +94% | added |
| PSquared Asset Management AG Hedge fund | 1.8% | $5.5m | 41,200 | +154% | added |
| Rangeley Capital, LLC Hedge fund | 1.6% | $1.7m | 13,000 | +225% | added |
| Summit Partners Public Asset Management, LLC Hedge fund | 1.4% | $54.6m | 410,000 | – | new |
| Boothbay Fund Management, LLC Hedge fund | 1.4% | $75.1m | 563,367 | +19% | added |
| Orbimed Advisors LLC Hedge fund | 1.4% | $72.8m | 546,522 | +17% | added |
| RA Capital Management, L.P. Hedge fund | 1.3% | $151m | 1.13m | – | new |
| Readystate Asset Management LP Hedge fund | 1.3% | $32.2m | 241,530 | +20% | added |
| Two Seas Capital LP Hedge fund | 1.2% | $32.6m | 244,590 | – | new |
| Beartown Capital Management, LLC Hedge fund | 1.2% | $2.7m | 20,000 | – | new |
| Nantahala Capital Management, LLC Hedge fund | 1.1% | $17.8m | 133,759 | −2.5% | reduced |
| Birchview Capital, LP Hedge fund | 1.1% | $2.3m | 17,000 | – | new |
| Resolute Capital Asset Partners LLC Hedge fund | 1.0% | $2.3m | 17,500 | – | new |
| Apis Capital Advisors, LLC Hedge fund | 1.0% | $9.9m | 74,000 | −43% | reduced |
| Diametric Capital, LP Hedge fund | 0.7% | $6.9m | 51,903 | +419% | added |
| Monimus Capital Management, LP Hedge fund | 0.7% | $2.9m | 21,644 | – | new |
| Nwi Management LP Hedge fund | 0.6% | $9.6m | 72,000 | – | new |
| PFM Health Sciences, LP Hedge fund | 0.5% | $5.8m | 43,264 | +62% | added |
| Seven Grand Managers, LLC Hedge fund | 0.5% | $12.0m | 90,000 | +80% | added |
| Iridian Asset Management LLC Hedge fund | 0.4% | $1.2m | 9,165 | – | new |
| Quinn Opportunity Partners LLC Hedge fund | 0.4% | $8.8m | 66,045 | +313% | added |
| Greenland Capital Management LP Hedge fund | 0.4% | $2.0m | 15,000 | +200% | added |
| FNY Investment Advisers, LLC Hedge fund | 0.4% | $1.0m | 7,605 | +7.8% | added |
| Atika Capital Management LLC Hedge fund | 0.4% | $3.6m | 27,000 | −6.3% | reduced |
| Alpine Associates Management Inc. Hedge fund | 0.3% | $5.1m | 38,500 | – | new |
| Senator Investment Group LP Hedge fund | 0.3% | $7.3m | 55,000 | – | new |
| Landscape Capital Management, L.L.C. Hedge fund | 0.3% | $4.0m | 30,353 | 0.0% | held |
| SummitTX Capital, L.P. Hedge fund | 0.2% | $8.7m | 65,216 | – | new |
| CenterBook Partners LP Hedge fund | 0.2% | $4.5m | 33,811 | +301% | added |
| Atom Investors LP Hedge fund | 0.2% | $2.3m | 17,379 | – | new |
| Perceptive Advisors LLC Hedge fund | 0.2% | $9.9m | 74,000 | −77% | reduced |
| Balyasny Asset Management L.P. Hedge fund | 0.1% | $80.5m | 603,840 | +183% | added |
| Holocene Advisors, LP Hedge fund | 0.1% | $55.8m | 418,657 | +62% | added |
| Ghisallo Capital Management LLC Hedge fund | 0.1% | $6.0m | 48,000 | – | new |
| Burkehill Global Management, LP Hedge fund | 0.1% | $3.2m | 24,000 | – | new |
| Citadel Advisors LLC Hedge fund | 0.1% | $192m | 1.44m | +164% | added |
| FORA Capital, LLC Hedge fund | 0.1% | $1.6m | 11,758 | −11% | reduced |
| Tudor Investment Corp ET AL Hedge fund | 0.1% | $25.0m | 187,335 | +84% | added |
| Verition Fund Management LLC Hedge fund | 0.10% | $14.1m | 105,791 | +308% | added |
| Farallon Capital Management, L.L.C. Hedge fund | 0.10% | $16.3m | 122,000 | +6000% | added |
| Woodline Partners LP Hedge fund | 0.09% | $30.2m | 226,966 | +0.5% | held |
| Mark Asset Management LP Hedge fund | 0.09% | $860k | 6,452 | – | new |
| Troluce Capital Advisors LLC Hedge fund | 0.05% | $133k | 1,000 | – | new |
| Maverick Capital Ltd Hedge fund | 0.05% | $5.3m | 40,000 | – | new |
| Voleon Capital Management LP Hedge fund | 0.05% | $2.6m | 19,715 | −73% | reduced |
| Prelude Capital Management, LLC Hedge fund | 0.04% | $545k | 4,089 | +16% | added |
| GABELLI & Co INVESTMENT ADVISERS, INC. Hedge fund | 0.04% | $267k | 2,000 | – | new |
| ExodusPoint Capital Management, LP Hedge fund | 0.04% | $4.2m | 31,209 | −78% | reduced |
| RTW Investments, LP Hedge fund | 0.03% | $3.5m | 26,400 | – | new |
| Mirabella Financial Services LLP Hedge fund | 0.03% | $311k | 2,337 | −45% | reduced |
| Gsa Capital Partners LLP Hedge fund | 0.03% | $419k | 3,142 | +69% | added |
| J. Goldman & Co LP Hedge fund | 0.03% | $726k | 5,446 | −57% | reduced |
| Catalyst Funds Management Pty Ltd Hedge fund | 0.02% | $400k | 3,000 | −40% | reduced |
| Millennium Management LLC Hedge fund | 0.02% | $31.1m | 233,740 | −61% | reduced |
| Centiva Capital, LP Hedge fund | 0.02% | $601k | 4,512 | −92% | reduced |
| Walleye Capital LLC Hedge fund | 0.02% | $4.2m | 31,632 | +268% | added |
| NINE MASTS CAPITAL Ltd Hedge fund | 0.01% | $133k | 998 | −87% | reduced |
| Qube Research & Technologies Ltd Hedge fund | 0.01% | $10.8m | 81,216 | – | new |
| Alyeska Investment Group, L.P. Hedge fund | 0.01% | $3.2m | 23,940 | – | new |
| D. E. Shaw & Co., Inc. Hedge fund | 0.01% | $12.0m | 90,357 | +79% | added |
| Schonfeld Strategic Advisors LLC Hedge fund | 0.01% | $1.2m | 8,918 | −38% | reduced |
| Adage Capital Partners GP, L.L.C. Hedge fund | 0.0% | $3.5m | 26,500 | −93% | reduced |
| Engineers Gate Manager LP Hedge fund | 0.0% | $284k | 2,133 | – | new |
| Quantbot Technologies LP Hedge fund | 0.0% | $41.6k | 312 | −6.0% | reduced |
| Point72 Asset Management, L.P. Hedge fund | 0.0% | $670k | 5,028 | −99% | reduced |