RTW Investments, LP 13F holdings, Q1 2025
Holdings as of March 31, 2025 · filings on SEC EDGAR · latest filing →
RTW Investments, LP disclosed 68 US equity positions worth $6.5bn in its Q1 2025 13F filing. The largest position was MDGL at 10.1% of the reported book, followed by ARGX and PTCT. Against the Q4 2024 filing, it opened 7 new positions, added to 15 and reduced 5 among the top 50 holdings.
What did RTW Investments, LP own in Q1 2025? Top 50 positions
| # | Stock | Sector | Weight | Value | Shares | Δ shares | vs Q4 2024 |
|---|---|---|---|---|---|---|---|
| 1 | MDGL MADRIGAL PHARMACEUTICALS INC | Healthcare | 10.1% | $660.4m | 1,993,687 | 0% | held |
| 2 | ARGX ARGENX SE | Healthcare | 6.1% | $398.6m | 673,497 | 0% | held |
| 3 | PTCT PTC THERAPEUTICS INC | Healthcare | 5.8% | $381.3m | 7,483,127 | 1% | added |
| 4 | NTRA NATERA INC | Healthcare | 5.6% | $366.8m | 2,593,546 | 0% | held |
| 5 | AXSM AXSOME THERAPEUTICS INC | Healthcare | 5.2% | $340.9m | 2,922,729 | -28% | reduced |
| 6 | AKERO THERAPEUTICS INC | 4.6% | $300.3m | 7,419,340 | 8% | added | |
| 7 | PTGX PROTAGONIST THERAPEUTICS INC | Healthcare | 4.2% | $276.6m | 5,719,415 | 4% | added |
| 8 | RNAGBP AVIDITY BIOSCIENCES INC | 3.9% | $258.2m | 8,746,926 | 10% | added | |
| 9 | PEN PENUMBRA INC | Healthcare | 3.5% | $230.7m | 862,770 | 0% | held |
| 10 | INSM INSMED INC | Healthcare | 3.5% | $230.0m | 3,014,558 | 0% | held |
| 11 | ALKS ALKERMES PLC | Healthcare | 3.5% | $227.3m | 6,884,698 | -9% | reduced |
| 12 | SYK STRYKER CORPORATION | Healthcare | 3.4% | $219.7m | 590,221 | 0% | held |
| 13 | VRNA VERONA PHARMA PLC | 2.8% | $180.9m | 2,848,800 | 56% | added | |
| 14 | MERUS N V | 2.7% | $175.5m | 4,169,393 | 0% | held | |
| 15 | TARS TARSUS PHARMACEUTICALS INC | Healthcare | 2.6% | $170.3m | 3,316,032 | 2% | added |
| 16 | IMCR IMMUNOCORE HLDGS PLC | Healthcare | 2.2% | $144.5m | 4,869,798 | 0% | held |
| 17 | ACAD ACADIA PHARMACEUTICALS INC | Healthcare | 2.2% | $141.9m | 8,540,117 | -2% | reduced |
| 18 | RCKT ROCKET PHARMACEUTICALS INC | Healthcare | 1.8% | $118.0m | 17,687,772 | 0% | held |
| 19 | RDNT RADNET INC | Healthcare | 1.8% | $115.2m | 2,317,582 | 17% | added |
| 20 | MASI* MASIMO CORP | 1.7% | $113.8m | 683,294 | 0% | held | |
| 21 | ZLAB ZAI LAB LTD | Healthcare | 1.7% | $113.4m | 3,136,680 | 25% | added |
| 22 | CYTK CYTOKINETICS INC | Healthcare | 1.7% | $109.4m | 2,721,158 | 0% | held |
| 23 | ESTA ESTABLISHMENT LABS HLDGS INC | Healthcare | 1.6% | $105.4m | 2,583,887 | 1% | added |
| 24 | APGE APOGEE THERAPEUTICS INC | Healthcare | 1.5% | $101.3m | 2,712,097 | 0% | held |
| 25 | ISRG INTUITIVE SURGICAL INC | Healthcare | 1.5% | $100.3m | 202,456 | – | new |
| 26 | GMED GLOBUS MED INC | Healthcare | 1.3% | $82.3m | 1,125,000 | 16% | added |
| 27 | RARE ULTRAGENYX PHARMACEUTICAL IN | Healthcare | 0.9% | $61.8m | 1,707,402 | -13% | reduced |
| 28 | GHRS GH RESEARCH PLC | 0.9% | $60.7m | 5,499,769 | 65% | added | |
| 29 | SYRE SPYRE THERAPEUTICS INC | 0.9% | $58.4m | 3,621,996 | 0% | held | |
| 30 | QURE UNIQURE NV | 0.7% | $45.2m | 4,265,428 | 372% | added | |
| 31 | URGN UROGEN PHARMA LTD | Healthcare | 0.6% | $42.4m | 3,834,794 | 0% | held |
| 32 | GEHC GE HEALTHCARE TECHNOLOGIES I | Healthcare | 0.6% | $42.0m | 520,000 | – | new |
| 33 | CGON CG ONCOLOGY INC | Healthcare | 0.6% | $41.7m | 1,701,216 | 0% | held |
| 34 | BBNX BETA BIONICS INC | Healthcare | 0.6% | $40.4m | 3,299,870 | – | new |
| 35 | OBIO ORCHESTRA BIOMED HLDGS INC | 0.5% | $35.1m | 8,206,162 | 0% | held | |
| 36 | STOK STOKE THERAPEUTICS INC | Healthcare | 0.5% | $34.1m | 5,123,525 | 0% | held |
| 37 | IMTX IMMATICS N.V | Healthcare | 0.5% | $31.2m | 6,909,510 | 6% | added |
| 38 | TSHA TAYSHA GENE THERAPIES INC | Healthcare | 0.4% | $26.1m | 18,787,866 | 117% | added |
| 39 | VSTM VERASTEM INC | Healthcare | 0.4% | $25.6m | 4,245,476 | – | new |
| 40 | XNCR XENCOR INC | Healthcare | 0.4% | $25.6m | 2,402,883 | 0% | held |
| 41 | ARVN ARVINAS INC | Healthcare | 0.4% | $23.4m | 3,334,308 | 0% | held |
| 42 | LENZ LENZ THERAPEUTICS INC | Healthcare | 0.3% | $22.2m | 863,389 | 0% | held |
| 43 | REPL REPLIMUNE GROUP INC | Healthcare | 0.3% | $20.1m | 2,065,010 | 0% | held |
| 44 | ORKA ORUKA THERAPEUTICS INC | Healthcare | 0.3% | $20.0m | 1,945,649 | 0% | held |
| 45 | TEM TEMPUS AI INC | Healthcare | 0.3% | $19.3m | 400,000 | – | new |
| 46 | GKOS GLAUKOS CORP | Healthcare | 0.3% | $18.7m | 190,000 | – | new |
| 47 | DYN DYNE THERAPEUTICS INC | Healthcare | 0.3% | $17.7m | 1,690,567 | -68% | reduced |
| 48 | CRGX CARGO THERAPEUTICS INC | 0.3% | $16.8m | 4,124,859 | 0% | held | |
| 49 | DGX QUEST DIAGNOSTICS INC | Healthcare | 0.3% | $16.8m | 98,997 | – | new |
| 50 | CMPS COMPASS PATHWAYS PLC | Healthcare | 0.2% | $15.8m | 5,538,168 | 79% | added |
Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.