| Fundsmith Investment Services Ltd. Hedge fund | 7.3% | $331m | 1.05m | −11% | reduced |
| Fundsmith (Terry Smith) Long-only investor | 6.7% | $917m | 2.91m | −4.8% | reduced |
| Ilex Capital Partners (UK) LLP Hedge fund | 2.6% | $126m | 399,898 | +98% | added |
| Sivik Global Healthcare LLC Hedge fund | 2.5% | $3.3m | 10,000 | 0.0% | held |
| Parkman Healthcare Partners LLC Hedge fund | 2.2% | $21.4m | 67,973 | −56% | reduced |
| NZS Capital, LLC Hedge fund | 2.1% | $81.4m | 258,631 | +11% | added |
| PFM Health Sciences, LP Hedge fund | 1.5% | $17.8m | 56,637 | +158% | added |
| Orbimed Advisors LLC Hedge fund | 0.9% | $50.1m | 159,100 | −13% | reduced |
| New Vernon Investment Management LLC Hedge fund | 0.8% | $680k | 2,160 | 0.0% | held |
| Teza Capital Management LLC Hedge fund | 0.7% | $366k | 1,164 | +7.5% | added |
| Jupiter Asset Management Ltd Hedge fund | 0.6% | $120m | 367,760 | +2.0% | added |
| Sone Capital Management, LLC Hedge fund | 0.5% | $7.0m | 22,151 | +356% | added |
| Arrowstreet Capital, Limited Partnership Hedge fund | 0.5% | $1.0bn | 3.28m | +111% | added |
| Rock Springs Capital Management LP Hedge fund | 0.4% | $9.1m | 29,000 | +96% | added |
| Corient IA LP Hedge fund | 0.4% | $384k | 1,220 | 0.0% | held |
| CTC Alternative Strategies, Ltd. Hedge fund | 0.3% | $227k | 720 | – | new |
| BlueSpruce Investments, LP Hedge fund | 0.3% | $2.0m | 6,474 | −97% | reduced |
| BTG Pactual Asset Management US LLC Hedge fund | 0.3% | $3.5m | 9,490 | −0.2% | held |
| Cinctive Capital Management LP Hedge fund | 0.2% | $5.9m | 18,642 | – | new |
| Candriam S.C.A. Hedge fund | 0.2% | $50.9m | 161,744 | −3.2% | reduced |
| Point72 Asset Management, L.P. Hedge fund | 0.2% | $135m | 430,094 | +1604% | added |
| Quantitative Investment Management, LLC Hedge fund | 0.2% | $1.9m | 5,942 | – | new |
| Persistent Asset Partners Ltd Hedge fund | 0.2% | $604k | 1,918 | +73% | added |
| IFM Investors Pty Ltd Hedge fund | 0.2% | $25.3m | 80,221 | +12% | added |
| Dymon Asia Capital (Singapore) Pte. Ltd. Hedge fund | 0.2% | $976k | 3,100 | – | new |
| AKO Capital LLP Hedge fund | 0.2% | $6.5m | 20,624 | −92% | reduced |
| Palogic Value Management, L.P. Hedge fund | 0.1% | $413k | 1,313 | +4.3% | added |
| Okabena Investment Services Inc Hedge fund | 0.1% | $805k | 2,558 | 0.0% | held |
| Davidson Kempner Capital Management LP Hedge fund | 0.1% | $8.9m | 28,281 | +61% | added |
| Adage Capital Partners GP, L.L.C. Hedge fund | 0.1% | $96.8m | 307,499 | – | new |
| Alyeska Investment Group, L.P. Hedge fund | 0.1% | $52.7m | 167,524 | – | new |
| Jain Global LLC Hedge fund | 0.1% | $11.5m | 36,477 | +632% | added |
| Edgestream Partners, L.P. Hedge fund | 0.1% | $4.0m | 12,637 | −7.8% | reduced |
| Voleon Capital Management LP Hedge fund | 0.1% | $6.4m | 20,281 | −25% | reduced |
| West Family Investments, Inc. Family office | 0.1% | $401k | 1,275 | +6.1% | added |
| ABS Investment Management LLC Hedge fund | 0.1% | $164k | 315 | – | |
| Fox Run Management, L.L.C. Hedge fund | 0.1% | $619k | 1,967 | −32% | reduced |
| Trust Asset Management LLC Hedge fund | 0.08% | $1.2m | 3,833 | +0.7% | added |
| Woodline Partners LP Hedge fund | 0.07% | $23.7m | 75,286 | −41% | reduced |
| Stevens Capital Management LP Hedge fund | 0.07% | $302k | 959 | −35% | reduced |
| Kintegral Advisory, LLC Hedge fund | 0.07% | $893k | 2,828 | 0.0% | held |
| First Manhattan Long-only investor | 0.07% | $27.9m | 88,504 | +26% | added |
| Tobam Hedge fund | 0.06% | $249k | 791 | −76% | reduced |
| Delta Global Management LP Hedge fund | 0.06% | $537k | 1,706 | – | new |
| Cohen Klingenstein LLC Hedge fund | 0.06% | $2.0m | 6,400 | 0.0% | held |
| Schonfeld Strategic Advisors LLC Hedge fund | 0.06% | $10.9m | 34,612 | −71% | reduced |
| D. E. Shaw & Co., Inc. Hedge fund | 0.05% | $85.2m | 270,554 | −55% | reduced |
| AQR Capital Management LLC Hedge fund | 0.05% | $150m | 476,095 | −51% | reduced |
| Catalyst Funds Management Pty Ltd Hedge fund | 0.05% | $844k | 2,680 | – | new |
| Pin Oak Investment Advisors Inc Hedge fund | 0.04% | $63.0k | 200 | +1.0% | added |
| Lowe Brockenbrough & Co Inc Hedge fund | 0.04% | $953k | 3,026 | +0.5% | held |
| Brevan Howard Capital Management LP Hedge fund | 0.04% | $2.8m | 9,013 | +10% | added |
| CVA Family Office, LLC Family office | 0.04% | $438k | 1,390 | −2.9% | reduced |
| Renaissance Technologies LLC Hedge fund | 0.04% | $28.7m | 91,300 | −77% | reduced |
| Montanova Capital, LLC Hedge fund | 0.04% | $1.8m | 5,860 | 0.0% | held |
| ADAR1 Capital Management, LLC Hedge fund | 0.03% | $630k | 2,000 | – | new |
| Citadel Advisors LLC Hedge fund | 0.03% | $48.0m | 152,464 | −0.1% | held |
| Caption Management, LLC Hedge fund | 0.02% | $567k | 1,800 | – | new |
| Millennium Management LLC Hedge fund | 0.02% | $29.1m | 92,570 | +244% | added |
| Quantbot Technologies LP Hedge fund | 0.02% | $451k | 1,431 | −95% | reduced |
| Laurion Capital Management LP Hedge fund | 0.02% | $228k | 724 | – | new |
| Bridgewater Associates, LP Hedge fund | 0.02% | $3.8m | 12,155 | −54% | reduced |
| Twin Tree Management, LP Hedge fund | 0.01% | $88.8k | 282 | – | new |
| Capstone Investment Advisors, LLC Hedge fund | 0.01% | $2.0m | 6,208 | −4.2% | reduced |
| Marshall Wace, LLP Hedge fund | 0.01% | $16.1m | 51,116 | −92% | reduced |
| CenterBook Partners LP Hedge fund | 0.01% | $264k | 840 | – | new |
| Boothbay Fund Management, LLC Hedge fund | 0.01% | $670k | 2,128 | −33% | reduced |
| Readystate Asset Management LP Hedge fund | 0.01% | $262k | 832 | +29% | added |
| Squarepoint Ops LLC Hedge fund | 0.01% | $5.4m | 17,021 | −85% | reduced |
| Verition Fund Management LLC Hedge fund | 0.01% | $1.0m | 3,266 | +14% | added |
| Engineers Gate Manager LP Hedge fund | 0.0% | $352k | 1,117 | −96% | reduced |
| Two Sigma Investments, LP Hedge fund | 0.0% | $4.1m | 13,024 | −97% | reduced |
| Hudson Bay Capital Management LP Hedge fund | 0.0% | $416k | 1,320 | – | new |
| Walleye Capital LLC Hedge fund | 0.0% | $60.8k | 193 | −73% | reduced |
| Parallax Volatility Advisers, L.P. Hedge fund | 0.0% | $315 | 1 | – | new |