| Darwin Global Management, Ltd. Hedge fund | 17.9% | $674m | 6.43m | −62% | reduced |
| Artia Global Partners LP Hedge fund | 11.9% | $62.8m | 589,052 | −6.3% | reduced |
| Integral Health Asset Management, LLC Hedge fund | 7.0% | $171m | 1.60m | +6.7% | added |
| Nwi Management LP Hedge fund | 6.9% | $108m | 1.01m | 0.0% | held |
| Prosight Management, LP Hedge fund | 6.9% | $40.0m | 375,609 | – | new |
| Eagle Health Investments LP Hedge fund | 6.8% | $41.0m | 384,130 | +71% | added |
| Palo Alto Investors LP Hedge fund | 6.1% | $44.1m | 413,980 | −0.3% | held |
| Baker Bros. Advisors LP Hedge fund | 4.7% | $938m | 8.80m | +19% | added |
| RTW Investments, LP Hedge fund | 4.4% | $516m | 4.84m | 0.0% | held |
| Defilade Capital Management, L.P. Hedge fund | 4.0% | $30.0m | 281,838 | +45% | added |
| Ishara Investments LP Hedge fund | 4.0% | $5.5m | 51,250 | – | new |
| Trails Edge Capital Partners, LP Hedge fund | 3.9% | $24.6m | 230,331 | – | new |
| Duquesne Family Office LLC Family office | 3.5% | $152m | 1.42m | +23% | added |
| Affinity Asset Advisors, LLC Hedge fund | 3.4% | $69.3m | 650,000 | +35% | added |
| Jones Hill Capital LP Hedge fund | 2.8% | $13.0m | 122,375 | – | new |
| Paradigm Biocapital Advisors LP Hedge fund | 2.6% | $141m | 1.33m | +5.7% | added |
| Long Focus Capital Management, LLC Hedge fund | 2.3% | $56.3m | 528,000 | +264% | added |
| KVP Capital Advisors, LP Hedge fund | 2.2% | $3.0m | 28,497 | 0.0% | held |
| Maverick Capital Ltd Hedge fund | 2.1% | $229m | 2.15m | – | new |
| Rock Springs Capital Management LP Hedge fund | 1.9% | $38.6m | 362,150 | +15% | added |
| Sphera Funds Management Ltd. Hedge fund | 1.8% | $12.7m | 118,800 | – | new |
| Elmind Capital, LP Hedge fund | 1.7% | $6.9m | 65,000 | – | new |
| GordonMD Global Investments LP Hedge fund | 1.5% | $3.0m | 28,587 | 0.0% | held |
| Samlyn Capital, LLC Hedge fund | 1.3% | $78.1m | 732,568 | +76% | added |
| ADAR1 Capital Management, LLC Hedge fund | 1.1% | $24.4m | 228,520 | +546% | added |
| Castle Hook Partners LP Hedge fund | 1.1% | $106m | 993,310 | −22% | reduced |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. Hedge fund | 0.9% | $3.2m | 30,170 | +330% | added |
| Exome Asset Management LLC Hedge fund | 0.9% | $1.5m | 13,873 | −48% | reduced |
| Sofinnova Investments, Inc. Hedge fund | 0.9% | $16.9m | 158,398 | −54% | reduced |
| Caption Management, LLC Hedge fund | 0.9% | $25.2m | 236,000 | – | new |
| Eversept Partners, LP Hedge fund | 0.9% | $15.9m | 149,209 | – | new |
| HighVista Strategies LLC Hedge fund | 0.8% | $3.3m | 31,256 | +29% | added |
| Cinctive Capital Management LP Hedge fund | 0.7% | $17.3m | 161,996 | +122% | added |
| Militia Capital Management LLC Hedge fund | 0.7% | $3.7m | 35,100 | – | new |
| Vestal Point Capital, LP Hedge fund | 0.6% | $26.7m | 250,000 | – | new |
| Kynam Capital Management, LP Hedge fund | 0.6% | $10.7m | 100,000 | – | new |
| Tobam Hedge fund | 0.6% | $2.4m | 22,370 | +0.3% | held |
| CenterBook Partners LP Hedge fund | 0.5% | $11.0m | 103,151 | +193% | added |
| Tremblant Capital Group Hedge fund | 0.5% | $18.2m | 170,670 | −1.7% | reduced |
| Cormorant Asset Management, LP Hedge fund | 0.4% | $8.0m | 75,000 | −61% | reduced |
| Silverarc Capital Management, LLC Hedge fund | 0.4% | $3.7m | 34,438 | −3.9% | reduced |
| D. E. Shaw & Co., Inc. Hedge fund | 0.4% | $627m | 5.88m | +4.5% | added |
| Redmile Group, LLC Hedge fund | 0.4% | $5.5m | 51,234 | – | new |
| Soleus Capital Management, L.P. Hedge fund | 0.3% | $9.6m | 90,250 | +780% | added |
| Qsemble Capital Management, LP Hedge fund | 0.3% | $2.3m | 21,148 | – | new |
| Polar Capital Holdings Plc Hedge fund | 0.3% | $95.0m | 890,872 | +142% | added |
| Candriam S.C.A. Hedge fund | 0.3% | $59.1m | 555,131 | +38% | added |
| Twinbeech Capital LP Hedge fund | 0.3% | $1.5m | 13,646 | – | new |
| Balyasny Asset Management L.P. Hedge fund | 0.3% | $141m | 1.33m | +498% | added |
| Campbell & CO Investment Adviser LLC Hedge fund | 0.2% | $4.7m | 43,856 | – | new |
| Atom Investors LP Hedge fund | 0.2% | $2.6m | 24,374 | +55% | added |
| Landscape Capital Management, L.L.C. Hedge fund | 0.2% | $3.3m | 31,345 | – | new |
| Y-Intercept (Hong Kong) Ltd Hedge fund | 0.2% | $10.9m | 101,908 | – | new |
| Qube Research & Technologies Ltd Hedge fund | 0.2% | $179m | 1.68m | +1033% | added |
| Bridgewater Associates, LP Hedge fund | 0.2% | $48.6m | 455,392 | +54% | added |
| Lecap Asset Management Ltd Hedge fund | 0.2% | $464k | 4,351 | – | new |
| 683 Capital Management, LLC Hedge fund | 0.2% | $2.1m | 20,000 | – | new |
| Entropy Technologies, LP Hedge fund | 0.2% | $4.8m | 45,469 | +950% | added |
| Quantitative Investment Management, LLC Hedge fund | 0.2% | $1.7m | 15,894 | +11% | added |
| MYDA Advisors LLC Hedge fund | 0.2% | $746k | 7,000 | 0.0% | held |
| Engineers Gate Manager LP Hedge fund | 0.2% | $13.4m | 126,044 | −21% | reduced |
| Catalyst Funds Management Pty Ltd Hedge fund | 0.2% | $2.8m | 26,200 | – | new |
| Citadel Advisors LLC Hedge fund | 0.2% | $273m | 2.56m | +17% | added |
| Millennium Management LLC Hedge fund | 0.1% | $218m | 2.05m | +77% | added |
| Jain Global LLC Hedge fund | 0.1% | $11.9m | 111,204 | – | new |
| Morgan Creek Capital Management, LLC Hedge fund | 0.1% | $206k | 1,929 | +54% | added |
| Squarepoint Ops LLC Hedge fund | 0.1% | $65.7m | 616,464 | +1468% | added |
| Adage Capital Partners GP, L.L.C. Hedge fund | 0.1% | $90.6m | 850,000 | −5.6% | reduced |
| Capital Fund Management S.A. Hedge fund | 0.1% | $15.9m | 148,976 | – | new |
| Quarry LP Hedge fund | 0.1% | $667k | 6,254 | – | new |
| Trexquant Investment LP Hedge fund | 0.1% | $16.7m | 156,553 | – | new |
| Two Sigma Investments, LP Hedge fund | 0.10% | $132m | 1.24m | +424% | added |
| Boothbay Fund Management, LLC Hedge fund | 0.09% | $5.0m | 47,266 | – | new |
| AlphaGrep UK Ltd Hedge fund | 0.09% | $300k | 2,811 | – | new |
| Point72 Asset Management, L.P. Hedge fund | 0.09% | $57.3m | 536,997 | – | new |
| Tudor Investment Corp ET AL Hedge fund | 0.09% | $20.8m | 195,391 | – | new |
| Fox Run Management, L.L.C. Hedge fund | 0.07% | $416k | 3,903 | – | new |
| ExodusPoint Capital Management, LP Hedge fund | 0.07% | $7.4m | 69,500 | −53% | reduced |
| Bayforest Capital Ltd Hedge fund | 0.07% | $70.7k | 663 | +103% | added |
| Dark Forest Capital Management LP Hedge fund | 0.06% | $998k | 9,356 | +281% | added |
| Schonfeld Strategic Advisors LLC Hedge fund | 0.06% | $11.1m | 104,378 | +86% | added |
| Hudson Bay Capital Management LP Hedge fund | 0.05% | $11.7m | 109,352 | – | new |
| SummitTX Capital, L.P. Hedge fund | 0.05% | $2.0m | 18,751 | −19% | reduced |
| Alyeska Investment Group, L.P. Hedge fund | 0.05% | $20.3m | 190,264 | +295% | added |
| Woodline Partners LP Hedge fund | 0.05% | $16.3m | 152,618 | +2.8% | added |
| FNY Investment Advisers, LLC Hedge fund | 0.05% | $138k | 1,300 | – | new |
| Holocene Advisors, LP Hedge fund | 0.05% | $20.6m | 192,879 | – | new |
| Marshall Wace, LLP Hedge fund | 0.05% | $53.5m | 501,930 | +61% | added |
| Laurion Capital Management LP Hedge fund | 0.04% | $611k | 5,728 | – | new |
| Aquatic Capital Management LLC Hedge fund | 0.04% | $1.1m | 10,593 | – | new |
| GABELLI & Co INVESTMENT ADVISERS, INC. Hedge fund | 0.04% | $267k | 2,500 | – | new |
| IFM Investors Pty Ltd Hedge fund | 0.04% | $5.8m | 53,953 | +26% | added |
| Brevan Howard Capital Management LP Hedge fund | 0.02% | $1.7m | 15,677 | +345% | added |
| AQR Capital Management LLC Hedge fund | 0.02% | $65.3m | 612,832 | −9.3% | reduced |
| DLD Asset Management, LP Hedge fund | 0.02% | $267k | 2,500 | – | new |
| Quinn Opportunity Partners LLC Hedge fund | 0.01% | $213k | 2,000 | – | new |
| Caxton Associates LLP Hedge fund | 0.01% | $504k | 4,726 | – | new |
| Quantbot Technologies LP Hedge fund | 0.01% | $162k | 1,520 | – | new |
| Verition Fund Management LLC Hedge fund | 0.0% | $707k | 6,633 | – | new |
| WCM Investment Management Long-only investor | 0.0% | $2.0m | 19,033 | +21% | added |
| Freestone Grove Partners LP Hedge fund | 0.0% | $294k | 2,754 | – | new |
| Walleye Capital LLC Hedge fund | 0.0% | $148k | 1,384 | −98% | reduced |
| CVA Family Office, LLC Family office | 0.0% | $4.1k | 38 | −5.0% | reduced |