| Sofinnova Investments, Inc. Hedge fund | 22.5% | $421m | 1.55m | 0.0% | held |
| Duquesne Family Office LLC Family office | 19.9% | $865m | 3.19m | +4.0% | added |
| Nwi Management LP Hedge fund | 13.2% | $207m | 762,603 | 0.0% | held |
| Castle Hook Partners LP Hedge fund | 7.6% | $705m | 2.60m | +2.6% | added |
| Beaconlight Capital, LLC Hedge fund | 6.4% | $14.5m | 53,312 | +59% | added |
| Blue Water Life Science Advisors, LP Hedge fund | 5.9% | $9.4m | 34,494 | −23% | reduced |
| Science & Technology Partners, L.P. Hedge fund | 5.0% | $29.8m | 109,880 | +10% | added |
| Avala Global LP Hedge fund | 4.6% | $125m | 460,000 | +202% | added |
| ThornTree Capital Partners LP Hedge fund | 4.3% | $31.5m | 116,021 | – | new |
| Catalio Capital Management, LP Hedge fund | 4.2% | $22.3m | 82,181 | +16% | added |
| Farallon Capital Management, L.L.C. Hedge fund | 3.5% | $602m | 2.22m | −31% | reduced |
| Maverick Capital Ltd Hedge fund | 3.3% | $368m | 1.36m | +16% | added |
| Pinnbrook Capital Management LP Hedge fund | 3.1% | $18.8m | 69,300 | – | new |
| IQ EQ FUND MANAGEMENT (SINGAPORE) PRIVATE Ltd Hedge fund | 3.0% | $1.8m | 6,500 | +110% | added |
| Summit Partners Public Asset Management, LLC Hedge fund | 2.7% | $106m | 389,000 | +4.7% | added |
| Eversept Partners, LP Hedge fund | 2.6% | $47.7m | 175,807 | −54% | reduced |
| Maplelane Capital, LLC Hedge fund | 2.5% | $60.3m | 222,000 | −35% | reduced |
| RTW Investments, LP Hedge fund | 2.3% | $271m | 1.00m | −20% | reduced |
| Exome Asset Management LLC Hedge fund | 2.3% | $3.7m | 13,800 | −26% | reduced |
| Zweig-DiMenna Associates LLC Hedge fund | 2.0% | $22.3m | 81,982 | +7.5% | added |
| Brandywine Managers, LLC Hedge fund | 2.0% | $4.0m | 14,588 | 0.0% | held |
| Encore Global Management, LP Hedge fund | 1.6% | $1.6m | 6,000 | 0.0% | held |
| MPM Bioimpact LLC Hedge fund | 1.5% | $25.1m | 92,638 | −0.5% | held |
| Coatue Management LLC Hedge fund | 1.4% | $680m | 2.51m | −1.4% | reduced |
| Orbimed Advisors LLC Hedge fund | 1.3% | $71.1m | 262,000 | 0.0% | held |
| PointState Capital LP Hedge fund | 1.2% | $70.0m | 258,012 | −65% | reduced |
| Pura Vida Investments, LLC Hedge fund | 1.1% | $407k | 1,500 | −40% | reduced |
| Braidwell LP Hedge fund | 0.8% | $21.6m | 79,500 | −38% | reduced |
| Eagle Health Investments LP Hedge fund | 0.7% | $4.3m | 15,847 | −87% | reduced |
| Sirios Capital Management L P Hedge fund | 0.7% | $5.7m | 20,933 | +213% | added |
| Intrepid Family Office LLC Family office | 0.6% | $679k | 2,500 | −44% | reduced |
| Tremblant Capital Group Hedge fund | 0.6% | $19.3m | 71,016 | – | new |
| PFM Health Sciences, LP Hedge fund | 0.5% | $6.0m | 22,077 | −63% | reduced |
| Rokos Capital Management LLP Hedge fund | 0.5% | $37.2m | 137,049 | −44% | reduced |
| Tobam Hedge fund | 0.5% | $1.9m | 7,056 | +9.4% | added |
| Corient IA LP Hedge fund | 0.4% | $475k | 1,750 | 0.0% | held |
| Scientech Research LLC Hedge fund | 0.4% | $496k | 1,827 | – | new |
| Kinetic Partners Management, LP Hedge fund | 0.4% | $16.5m | 60,800 | 0.0% | held |
| Senator Investment Group LP Hedge fund | 0.3% | $8.8m | 32,500 | – | new |
| Viking Global Investors LP Hedge fund | 0.3% | $106m | 390,694 | – | new |
| Fox Run Management, L.L.C. Hedge fund | 0.3% | $1.6m | 5,952 | +120% | added |
| Atreides Management, LP Hedge fund | 0.3% | $28.3m | 104,385 | – | new |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. Hedge fund | 0.2% | $764k | 2,814 | −5.3% | reduced |
| AQR Capital Management LLC Hedge fund | 0.2% | $628m | 2.34m | +3.1% | added |
| D. E. Shaw & Co., Inc. Hedge fund | 0.2% | $347m | 1.28m | +160% | added |
| Gsa Capital Partners LLP Hedge fund | 0.2% | $3.1m | 11,336 | +783% | added |
| Tudor Investment Corp ET AL Hedge fund | 0.2% | $45.8m | 168,837 | +12% | added |
| Graham Capital Management, L.P. Hedge fund | 0.2% | $7.0m | 25,748 | 0.0% | held |
| Arrowstreet Capital, Limited Partnership Hedge fund | 0.2% | $408m | 1.50m | +26% | added |
| Squarepoint Ops LLC Hedge fund | 0.2% | $91.3m | 336,268 | – | new |
| EntryPoint Capital, LLC Hedge fund | 0.2% | $701k | 2,582 | – | new |
| Entropy Technologies, LP Hedge fund | 0.1% | $3.7m | 13,559 | – | new |
| Perceptive Advisors LLC Hedge fund | 0.1% | $9.4m | 34,689 | – | new |
| Engineers Gate Manager LP Hedge fund | 0.1% | $11.1m | 40,839 | +44% | added |
| Oxford Asset Management LLP Hedge fund | 0.1% | $286k | 1,054 | – | new |
| Bayforest Capital Ltd Hedge fund | 0.1% | $150k | 551 | – | new |
| Brevan Howard Capital Management LP Hedge fund | 0.1% | $9.5m | 35,098 | +14% | added |
| Twin Tree Management, LP Hedge fund | 0.1% | $853k | 3,141 | +2176% | added |
| Jain Global LLC Hedge fund | 0.1% | $9.5m | 34,912 | – | new |
| Aquatic Capital Management LLC Hedge fund | 0.1% | $3.2m | 11,644 | +147% | added |
| Point72 Asset Management, L.P. Hedge fund | 0.1% | $68.7m | 252,920 | −43% | reduced |
| Candriam S.C.A. Hedge fund | 0.1% | $23.2m | 85,677 | 0.0% | held |
| West Family Investments, Inc. Family office | 0.08% | $288k | 1,060 | – | new |
| Boothbay Fund Management, LLC Hedge fund | 0.08% | $4.1m | 15,040 | +3.0% | added |
| CenterBook Partners LP Hedge fund | 0.07% | $1.4m | 5,099 | −89% | reduced |
| Trexquant Investment LP Hedge fund | 0.06% | $9.6m | 35,374 | −73% | reduced |
| Montanova Capital, LLC Hedge fund | 0.06% | $2.7m | 10,100 | 0.0% | held |
| IFM Investors Pty Ltd Hedge fund | 0.05% | $8.2m | 30,278 | +16% | added |
| Qube Research & Technologies Ltd Hedge fund | 0.05% | $43.7m | 161,079 | −47% | reduced |
| Citadel Advisors LLC Hedge fund | 0.04% | $72.1m | 265,607 | +138% | added |
| Caption Management, LLC Hedge fund | 0.04% | $1.2m | 4,275 | – | new |
| Machina Capital S.A.S. Hedge fund | 0.04% | $255k | 939 | – | new |
| Capital Fund Management S.A. Hedge fund | 0.04% | $5.0m | 18,559 | −79% | reduced |
| Marshall Wace, LLP Hedge fund | 0.03% | $35.7m | 131,663 | +145% | added |
| Prelude Capital Management, LLC Hedge fund | 0.03% | $388k | 1,428 | −75% | reduced |
| ADAR1 Capital Management, LLC Hedge fund | 0.03% | $583k | 2,147 | 0.0% | held |
| Millennium Management LLC Hedge fund | 0.03% | $39.1m | 143,927 | −7.9% | reduced |
| J. Goldman & Co LP Hedge fund | 0.02% | $631k | 2,325 | – | new |
| FNY Investment Advisers, LLC Hedge fund | 0.02% | $59.0k | 220 | – | new |
| Campbell & CO Investment Adviser LLC Hedge fund | 0.01% | $243k | 896 | −59% | reduced |
| Soleus Capital Management, L.P. Hedge fund | 0.01% | $271k | 1,000 | −99% | reduced |
| Bridgewater Associates, LP Hedge fund | 0.01% | $1.7m | 6,136 | −76% | reduced |
| Two Sigma Investments, LP Hedge fund | 0.01% | $8.8m | 32,600 | −19% | reduced |
| Woodline Partners LP Hedge fund | 0.01% | $2.1m | 7,685 | +49% | added |
| Polar Capital Holdings Plc Hedge fund | 0.01% | $2.3m | 8,351 | 0.0% | held |
| Voleon Capital Management LP Hedge fund | 0.0% | $260k | 956 | −83% | reduced |
| Polen Capital Long-only investor | 0.0% | $442k | 1,627 | +28% | added |
| Capstone Investment Advisors, LLC Hedge fund | 0.0% | $374k | 1,379 | – | new |
| CVA Family Office, LLC Family office | 0.0% | $28.2k | 104 | +16% | added |
| Quantbot Technologies LP Hedge fund | 0.0% | $57.0k | 210 | – | new |
| Quarry LP Hedge fund | 0.0% | $3.3k | 12 | – | new |
| Walleye Capital LLC Hedge fund | 0.0% | $13.8k | 51 | −100% | reduced |