WhaleCreep

Which hedge funds own SYRE? SPYRE THERAPEUTICS INC, Q2 2026 13F holders

HealthcareBiotechnology

62 tracked hedge funds disclosed a position in SYRE (SPYRE THERAPEUTICS INC) in their Q2 2026 13F filings, worth $2.4bn in total. The largest holder by portfolio weight is Venrock Adviser, LLC at 8.0% of its book. 30 opened a new position this quarter: Integral Health Asset Management, LLC, Cormorant Asset Management, LP, Boxer Capital Management, LLC, Diadema Partners LP. 11 exited: Fairmount Funds Management LLC, Caligan Partners LP, RA Capital Management, L.P..

62
Holders
Tracked managers whose filing for the quarter reports a long equity position in the security.
30
New this quarter
Holders whose previous filing (at most two quarters earlier) did not report the security.
11
Exited this quarter
Tracked managers whose previous filing reported the security and whose filing for the quarter does not.
$386m
Inflow, new holders
Combined value of the positions the new holders reported for the quarter.
$386m
Outflow, exits
Combined value the exiting managers reported for the security in their previous filing.
$2.4bn
Combined value
Sum of the holders' reported positions in the security.
5.0%
Share of managers holding
Holders as a share of tracked managers filing for that quarter. Comparable across the 2024 coverage expansion, where the raw holder count is not.

Holders, Q2 2026

62 rows
Venrock Adviser, LLC Hedge fund8.0%$265m2.99m−19%reduced
Paradigm Biocapital Advisors LP Hedge fund6.4%$341m3.84m+96%added
Perceptive Advisors LLC Hedge fund6.0%$383m4.32m+14%added
Affinity Asset Advisors, LLC Hedge fund5.6%$114m1.28m0.0%held
Commodore Capital LP Hedge fund4.5%$75.2m846,786−56%reduced
B Group, Inc. Hedge fund3.5%$6.2m70,000−30%reduced
RTW Investments, LP Hedge fund3.2%$377m4.25m+1.9%added
Braidwell LP Hedge fund2.9%$78.1m879,467−5.7%reduced
Stempoint Capital LP Hedge fund1.6%$9.5m106,926−36%reduced
HighVista Strategies LLC Hedge fund1.6%$6.9m77,807−47%reduced
ADAR1 Capital Management, LLC Hedge fund1.2%$25.2m283,982−16%reduced
Integral Health Asset Management, LLC Hedge fund1.2%$28.9m325,000–new
Cormorant Asset Management, LP Hedge fund1.0%$20.0m225,000–new
Seven Grand Managers, LLC Hedge fund0.8%$20.0m225,000+125%added
Boxer Capital Management, LLC Hedge fund0.7%$8.9m100,000–new
Silverarc Capital Management, LLC Hedge fund0.6%$5.3m59,959−68%reduced
Samlyn Capital, LLC Hedge fund0.6%$35.5m400,075+0.9%added
Diadema Partners LP Hedge fund0.5%$1.3m15,000–new
Soleus Capital Management, L.P. Hedge fund0.4%$13.1m147,000–new
PFM Health Sciences, LP Hedge fund0.4%$4.1m46,217–new
Armistice Capital, LLC Hedge fund0.3%$12.2m137,588+14%added
Orbimed Advisors LLC Hedge fund0.3%$16.5m186,145–new
Polar Capital Holdings Plc Hedge fund0.2%$87.7m988,009+25%added
Persistent Asset Partners Ltd Hedge fund0.2%$778k8,760+82%added
Candriam S.C.A. Hedge fund0.2%$48.5m546,312−10%reduced
Adage Capital Partners GP, L.L.C. Hedge fund0.2%$153m1.72m–new
Holocene Advisors, LP Hedge fund0.2%$90.1m1.02m–new
Seven Fleet Capital Management LP Hedge fund0.2%$1.2m13,300−32%reduced
Bayforest Capital Ltd Hedge fund0.2%$205k2,305–new
Rock Springs Capital Management LP Hedge fund0.2%$3.8m42,254–new
Cinctive Capital Management LP Hedge fund0.2%$4.3m48,978+79%added
ABS Investment Management LLC Hedge fund0.1%$186k89–
Caption Management, LLC Hedge fund0.1%$3.2m36,000–new
Global Endowment Management, LP Hedge fund0.1%$1.1m12,123−33%reduced
Atom Investors LP Hedge fund0.10%$1.1m12,457–new
Diametric Capital, LP Hedge fund0.09%$888k10,000–new
Woodline Partners LP Hedge fund0.08%$27.2m306,049+15%added
Aquatic Capital Management LLC Hedge fund0.08%$2.2m25,222–new
Marshall Wace, LLP Hedge fund0.07%$88.0m991,693+612%added
Artia Global Partners LP Hedge fund0.07%$355k4,000–new
Ghisallo Capital Management LLC Hedge fund0.05%$2.7m30,000–new
Wexford Capital LP Hedge fund0.05%$355k4,000–new
Engineers Gate Manager LP Hedge fund0.04%$3.4m38,474–new
Trexquant Investment LP Hedge fund0.04%$5.9m67,007–new
Quantbot Technologies LP Hedge fund0.03%$789k8,884+9995%added
Dark Forest Capital Management LP Hedge fund0.03%$461k5,192–new
Hudson Bay Capital Management LP Hedge fund0.02%$5.2m58,387–new
Squarepoint Ops LLC Hedge fund0.02%$12.4m139,605–new
Balyasny Asset Management L.P. Hedge fund0.02%$13.1m147,042+165%added
Landscape Capital Management, L.L.C. Hedge fund0.02%$344k3,875−25%reduced