Octagon Capital Advisors LP: 13F holdings, Q2 2026
Hedge fund · SEC EDGAR filings (CIK 1839435) · Explore on the interactive board
Octagon Capital Advisors LP disclosed 26 US equity positions worth $1.1bn in its Q2 2026 13F filing (holdings as of June 30, 2026, filed August 14, 2026). Its largest position is DNTH at 16.5% of the reported book, followed by DFTX, ABVX. The top ten holdings are 80.2% of the book, and the portfolio behaves like about 12 equal-weight positions. Versus the prior filing it opened 4 new positions, added to 4, reduced 6 and exited 7. Note: this manager's most recent filing is 3934 quarters behind the newest quarter on file, so these figures are history rather than current positioning.
What does Octagon Capital Advisors LP own? Top holdings as of June 30, 2026
Change is measured in shares against the previous filing (Q1 2026), so price moves do not read as decisions. This quarter: 4 new, 4 added, 6 reduced, 7 exited.
| # | Stock | Sector | Weight | Value | Shares | Δ shares | Action |
|---|---|---|---|---|---|---|---|
| 1 | DNTH DIANTHUS THERAPEUTICS INC | Healthcare | 16.5% | $179.5m | 1,841,667 | -5% | reduced |
| 2 | DFTX DEFINIUM THERAPEUTICS INC | Healthcare | 12.7% | $138.8m | 2,950,000 | 21% | added |
| 3 | ABVX ABIVAX SA | Healthcare | 12.1% | $132.3m | 993,000 | 47% | added |
| 4 | COGT COGENT BIOSCIENCES INC | Healthcare | 8.3% | $90.9m | 2,350,000 | 0% | held |
| 5 | ALMS ALUMIS INC | Healthcare | 7.3% | $79.7m | 2,830,700 | 0% | held |
| 6 | AVBP ARRIVENT BIOPHARMA INC | Healthcare | 6.3% | $68.5m | 1,971,054 | 0% | held |
| 7 | TSHA TAYSHA GENE THERAPIES INC | Healthcare | 6.1% | $66.0m | 9,693,244 | 9% | added |
| 8 | BIOA BIOAGE LABS INC | 3.9% | $42.8m | 1,748,000 | 0% | held | |
| 9 | MIRM MIRUM PHARMACEUTICALS INC | Healthcare | 3.6% | $39.7m | 338,900 | 0% | held |
| 10 | KYMR KYMERA THERAPEUTICS INC | Healthcare | 3.3% | $35.5m | 310,000 | -27% | reduced |
| 11 | AKTS AKTIS ONCOLOGY INC | 2.8% | $31.0m | 960,847 | 0% | held | |
| 12 | XENE XENON PHARMACEUTICALS INC | Healthcare | 2.7% | $29.6m | 490,000 | 0% | held |
| 13 | PALI PALISADE BIO INC | Healthcare | 2.0% | $21.5m | 10,276,317 | 0% | held |
| 14 | OCUL OCULAR THERAPEUTIX INC | Healthcare | 1.9% | $20.4m | 2,075,000 | -34% | reduced |
| 15 | IRON DISC MEDICINE INC | Healthcare | 1.8% | $19.7m | 270,000 | 0% | held |
| 16 | SMMT SUMMIT THERAPEUTICS INC | Healthcare | 1.7% | $18.2m | 1,250,000 | – | new |
| 17 | PHVS PHARVARIS N V | Healthcare | 1.4% | $15.8m | 456,721 | 177% | added |
| 18 | ANL ADLAI NORTYE LTD | 1.0% | $10.7m | 934,716 | – | new | |
| 19 | DTIL PRECISION BIOSCIENCES INC | 1.0% | $10.6m | 1,350,000 | -40% | reduced | |
| 20 | DBVT DBV TECHNOLOGIES S A | 0.9% | $9.4m | 574,200 | 0% | held | |
| 21 | FTH FAETH THERAPEUTICS INC | 0.8% | $9.0m | 361,010 | – | new | |
| 22 | GYRE GYRE THERAPEUTICS INC | 0.6% | $6.3m | 954,416 | – | new | |
| 23 | TRVI TREVI THERAPEUTICS INC | Healthcare | 0.5% | $5.9m | 315,000 | -79% | reduced |
| 24 | UNCY UNICYCIVE THERAPEUTICS INC | 0.4% | $4.7m | 1,000,000 | 0% | held | |
| 25 | CNTX CONTEXT THERAPEUTICS INC | 0.2% | $1.7m | 3,050,000 | -42% | reduced | |
| 26 | GOSS GOSSAMER BIO INC | Healthcare | 0.1% | $1.3m | 7,750,000 | 0% | held |
What did Octagon Capital Advisors LP sell? Positions exited since the previous filing
| Stock | Prior weight | Prior value |
|---|---|---|
| CNTA CENTESSA PHARMACEUTICALS PLC | 28.0% | $29.8m |
| 4XC1 KALVISTA PHARMACEUTICALS INC | 27.5% | $29.2m |
| 430 TERNS PHARMACEUTICALS INC | 26.3% | $27.9m |
| BBOT BRIDGEBIO ONCOLOGY THERAPEUT | 6.1% | $6.4m |
| LXEO LEXEO THERAPEUTICS INC | 5.9% | $6.3m |
| CATX PERSPECTIVE THERAPEUTICS INC | 3.1% | $3.3m |
| EVMN EVOMMUNE INC | 3.1% | $3.3m |
Sector mix
| Sector | Weight |
|---|---|
| Healthcare | 88.4% |
Sectors cover positions whose ticker resolved to a sector; the remainder is unclassified, not cash.
Filing history
How concentrated is Octagon Capital Advisors LP's portfolio?
Across every quarter Octagon Capital Advisors LP has filed, its median largest position is 17.3% of the book and its median top-ten weight is 74.4%, which WhaleCreep classifies as concentrated (the gate is a median largest position of 5%). Of 7.0 completed holding spells, the median lasted 1.0 quarters; 26.0 positions are still open and their final length is unknown.