Rock Springs Capital Management LP 13F holdings, Q4 2025
Holdings as of December 31, 2025 · filings on SEC EDGAR · latest filing →
Rock Springs Capital Management LP disclosed 98 US equity positions worth $1.9bn in its Q4 2025 13F filing. The largest position was LLY at 5.8% of the reported book, followed by RVMD and ARGX. Against the Q3 2025 filing, it opened 1 new position, added to 18 and reduced 21 among the top 50 holdings.
What did Rock Springs Capital Management LP own in Q4 2025? Top 50 positions
| # | Stock | Sector | Weight | Value | Shares | Δ shares | vs Q3 2025 |
|---|---|---|---|---|---|---|---|
| 1 | LLY ELI LILLY & CO | Healthcare | 5.8% | $113.3m | 105,400 | 0% | held |
| 2 | RVMD REVOLUTION MEDICINES INC | Healthcare | 5.5% | $106.4m | 1,335,270 | 0% | held |
| 3 | ARGX ARGENX SE | Healthcare | 4.5% | $86.8m | 103,250 | -28% | reduced |
| 4 | TVTX TRAVERE THERAPEUTICS INC | Healthcare | 4.3% | $84.5m | 2,210,322 | 2% | added |
| 5 | MDGL MADRIGAL PHARMACEUTICALS INC | Healthcare | 4.2% | $81.3m | 139,618 | 1% | added |
| 6 | RYTM RHYTHM PHARMACEUTICALS INC | Healthcare | 3.8% | $74.4m | 695,010 | -3% | reduced |
| 7 | EXK EXACT SCIENCES CORP | Basic Materials | 3.1% | $61.1m | 601,800 | 1% | added |
| 8 | MIRM MIRUM PHARMACEUTICALS INC | Healthcare | 3.1% | $60.2m | 762,294 | 0% | held |
| 9 | INSM INSMED INC | Healthcare | 2.9% | $55.6m | 319,250 | -17% | reduced |
| 10 | GPCR STRUCTURE THERAPEUTICS INC | Healthcare | 2.7% | $52.0m | 748,236 | -21% | reduced |
| 11 | ISRG INTUITIVE SURGICAL INC | Healthcare | 2.4% | $46.4m | 82,000 | 0% | held |
| 12 | CDTX CIDARA THERAPEUTICS INC | 2.3% | $45.3m | 204,878 | -18% | reduced | |
| 13 | ASND ASCENDIS PHARMA A/S | Healthcare | 2.2% | $43.4m | 203,500 | -5% | reduced |
| 14 | IRTC IRHYTHM TECHNOLOGIES INC | Healthcare | 2.1% | $41.7m | 235,000 | 0% | held |
| 15 | KYMR KYMERA THERAPEUTICS INC | Healthcare | 2.0% | $38.7m | 496,871 | 10% | added |
| 16 | BSX BOSTON SCIENTIFIC CORP | Healthcare | 2.0% | $38.0m | 399,050 | 11% | added |
| 17 | PEN PENUMBRA INC | Healthcare | 1.9% | $37.5m | 120,500 | 0% | held |
| 18 | XENE XENON PHARMACEUTICALS INC | Healthcare | 1.8% | $35.3m | 787,788 | -8% | reduced |
| 19 | SRRK SCHOLAR ROCK HLDG CORP | Healthcare | 1.7% | $32.3m | 733,477 | -8% | reduced |
| 20 | COGT COGENT BIOSCIENCES INC | Healthcare | 1.5% | $30.2m | 849,030 | -16% | reduced |
| 21 | RARE ULTRAGENYX PHARMACEUTICAL IN | Healthcare | 1.5% | $29.1m | 1,267,241 | 2% | added |
| 22 | VERA VERA THERAPEUTICS INC | Healthcare | 1.5% | $28.8m | 568,579 | -8% | reduced |
| 23 | ALNY ALNYLAM PHARMACEUTICALS INC | Healthcare | 1.5% | $28.3m | 71,250 | -4% | reduced |
| 24 | AM6 AMICUS THERAPEUTICS INC | 1.4% | $27.5m | 1,929,931 | -1% | reduced | |
| 25 | XBI SPDR SERIES TRUST | 1.4% | $27.1m | 222,000 | 46% | added | |
| 26 | THC TENET HEALTHCARE CORP | Healthcare | 1.3% | $24.8m | 125,000 | 0% | held |
| 27 | DXCM DEXCOM INC | Healthcare | 1.2% | $23.1m | 347,300 | 10% | added |
| 28 | AGIO AGIOS PHARMACEUTICALS INC | Healthcare | 1.1% | $21.8m | 799,163 | -17% | reduced |
| 29 | TARS TARSUS PHARMACEUTICALS INC | Healthcare | 1.1% | $21.3m | 260,344 | -10% | reduced |
| 30 | CMPX COMPASS THERAPEUTICS INC | 1.1% | $21.1m | 3,927,202 | -12% | reduced | |
| 31 | NEWAMSTERDAM PHARMA COMPANY | 1.0% | $19.5m | 557,194 | -6% | reduced | |
| 32 | AZTA AZENTA INC | Healthcare | 1.0% | $18.9m | 569,100 | 5% | added |
| 33 | CLDX CELLDEX THERAPEUTICS INC NEW | Healthcare | 1.0% | $18.8m | 692,538 | -4% | reduced |
| 34 | CAI CARIS LIFE SCIENCES INC | Healthcare | 1.0% | $18.5m | 687,500 | -13% | reduced |
| 35 | ZBIO ZENAS BIOPHARMA INC | 0.9% | $18.2m | 502,077 | -14% | reduced | |
| 36 | DYN DYNE THERAPEUTICS INC | Healthcare | 0.9% | $17.9m | 912,955 | 11% | added |
| 37 | NBIX NEUROCRINE BIOSCIENCES INC | Healthcare | 0.9% | $17.8m | 125,500 | 40% | added |
| 38 | PHVS PHARVARIS N V | 0.9% | $17.3m | 623,402 | 0% | held | |
| 39 | MLYS MINERALYS THERAPEUTICS INC | Healthcare | 0.8% | $15.5m | 427,596 | 5% | added |
| 40 | PHR PHREESIA INC | Healthcare | 0.8% | $14.8m | 876,600 | 17% | added |
| 41 | ZLAB ZAI LAB LTD | Healthcare | 0.7% | $14.3m | 811,546 | 3% | added |
| 42 | DHR DANAHER CORPORATION | Healthcare | 0.7% | $14.1m | 61,500 | 0% | held |
| 43 | UNH UNITEDHEALTH GROUP INC | Healthcare | 0.7% | $13.5m | 40,800 | – | new |
| 44 | ARDX ARDELYX INC | Healthcare | 0.7% | $13.4m | 2,299,473 | 1% | added |
| 45 | ACRS ACLARIS THERAPEUTICS INC | Healthcare | 0.7% | $13.4m | 4,453,741 | -3% | reduced |
| 46 | SMMT SUMMIT THERAPEUTICS INC | Healthcare | 0.6% | $12.4m | 710,000 | 0% | held |
| 47 | ELVN ENLIVEN THERAPEUTICS INC | Healthcare | 0.6% | $12.3m | 798,405 | 16% | added |
| 48 | INSP INSPIRE MED SYS INC | Healthcare | 0.6% | $12.1m | 131,000 | 19% | added |
| 49 | OMDA OMADA HEALTH INC | Healthcare | 0.6% | $11.7m | 740,000 | -20% | reduced |
| 50 | SLNOEUR SOLENO THERAPEUTICS INC | 0.6% | $11.4m | 247,053 | 60% | added |
Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.