Rock Springs Capital Management LP 13F holdings, Q3 2025
Holdings as of September 30, 2025 · filings on SEC EDGAR · latest filing →
Rock Springs Capital Management LP disclosed 92 US equity positions worth $1.7bn in its Q3 2025 13F filing. The largest position was ARGX at 6.2% of the reported book, followed by LLY and RYTM. Against the Q2 2025 filing, it opened 0 new positions, added to 13 and reduced 26 among the top 50 holdings.
What did Rock Springs Capital Management LP own in Q3 2025? Top 50 positions
| # | Stock | Sector | Weight | Value | Shares | Δ shares | vs Q2 2025 |
|---|---|---|---|---|---|---|---|
| 1 | ARGX ARGENX SE | Healthcare | 6.2% | $105.3m | 142,750 | -19% | reduced |
| 2 | LLY ELI LILLY & CO | Healthcare | 4.7% | $80.4m | 105,400 | -10% | reduced |
| 3 | RYTM RHYTHM PHARMACEUTICALS INC | Healthcare | 4.2% | $72.4m | 717,102 | -17% | reduced |
| 4 | MDGL MADRIGAL PHARMACEUTICALS INC | Healthcare | 3.7% | $63.2m | 137,746 | -2% | reduced |
| 5 | RVMD REVOLUTION MEDICINES INC | Healthcare | 3.6% | $62.4m | 1,335,270 | 0% | held |
| 6 | MERUS N V | 3.3% | $56.2m | 597,051 | -44% | reduced | |
| 7 | MIRM MIRUM PHARMACEUTICALS INC | Healthcare | 3.3% | $55.8m | 761,126 | -7% | reduced |
| 8 | INSM INSMED INC | Healthcare | 3.2% | $55.4m | 385,000 | -27% | reduced |
| 9 | TVTX TRAVERE THERAPEUTICS INC | Healthcare | 3.0% | $51.7m | 2,164,773 | 13% | added |
| 10 | ASND ASCENDIS PHARMA A/S | Healthcare | 2.5% | $42.6m | 214,500 | -1% | reduced |
| 11 | IRTC IRHYTHM TECHNOLOGIES INC | Healthcare | 2.4% | $40.4m | 235,000 | -3% | reduced |
| 12 | AGIO AGIOS PHARMACEUTICALS INC | Healthcare | 2.2% | $38.5m | 958,542 | -3% | reduced |
| 13 | RARE ULTRAGENYX PHARMACEUTICAL IN | Healthcare | 2.2% | $37.5m | 1,246,341 | -10% | reduced |
| 14 | ISRG INTUITIVE SURGICAL INC | Healthcare | 2.1% | $36.7m | 82,000 | 0% | held |
| 15 | BSX BOSTON SCIENTIFIC CORP | Healthcare | 2.1% | $35.2m | 360,250 | 1% | added |
| 16 | XENE XENON PHARMACEUTICALS INC | Healthcare | 2.0% | $34.2m | 851,744 | -9% | reduced |
| 17 | ALNY ALNYLAM PHARMACEUTICALS INC | Healthcare | 2.0% | $33.9m | 74,250 | -26% | reduced |
| 18 | EXK EXACT SCIENCES CORP | Basic Materials | 1.9% | $32.5m | 593,500 | 4% | added |
| 19 | PEN PENUMBRA INC | Healthcare | 1.8% | $30.5m | 120,500 | -6% | reduced |
| 20 | AKERO THERAPEUTICS INC | 1.7% | $29.7m | 626,526 | -2% | reduced | |
| 21 | SRRK SCHOLAR ROCK HLDG CORP | Healthcare | 1.7% | $29.6m | 794,133 | 0% | held |
| 22 | ZLAB ZAI LAB LTD | Healthcare | 1.6% | $26.8m | 791,193 | -9% | reduced |
| 23 | GPCR STRUCTURE THERAPEUTICS INC | Healthcare | 1.6% | $26.6m | 951,154 | -16% | reduced |
| 24 | KYMR KYMERA THERAPEUTICS INC | Healthcare | 1.5% | $25.5m | 450,374 | 0% | held |
| 25 | THC TENET HEALTHCARE CORP | Healthcare | 1.5% | $25.4m | 125,000 | -4% | reduced |
| 26 | EVH EVOLENT HEALTH INC | Healthcare | 1.5% | $25.0m | 2,950,000 | 5% | added |
| 27 | CAI CARIS LIFE SCIENCES INC | Healthcare | 1.4% | $24.0m | 793,651 | 0% | held |
| 28 | CDTX CIDARA THERAPEUTICS INC | 1.4% | $23.9m | 249,402 | 86% | added | |
| 29 | DXCM DEXCOM INC | Healthcare | 1.2% | $21.3m | 316,900 | 11% | added |
| 30 | OMDA OMADA HEALTH INC | Healthcare | 1.2% | $20.3m | 919,950 | -0% | held |
| 31 | CLDX CELLDEX THERAPEUTICS INC NEW | Healthcare | 1.1% | $18.7m | 721,538 | -11% | reduced |
| 32 | VERA VERA THERAPEUTICS INC | Healthcare | 1.0% | $17.9m | 617,396 | 0% | held |
| 33 | PHR PHREESIA INC | Healthcare | 1.0% | $17.6m | 749,116 | -11% | reduced |
| 34 | TARS TARSUS PHARMACEUTICALS INC | Healthcare | 1.0% | $17.1m | 288,344 | -23% | reduced |
| 35 | NEWAMSTERDAM PHARMA COMPANY | 1.0% | $16.9m | 595,929 | 11% | added | |
| 36 | CMPX COMPASS THERAPEUTICS INC | 0.9% | $15.7m | 4,474,702 | -10% | reduced | |
| 37 | PHVS PHARVARIS N V | 0.9% | $15.6m | 623,402 | 0% | held | |
| 38 | AZTA AZENTA INC | Healthcare | 0.9% | $15.5m | 540,400 | 2% | added |
| 39 | MLYS MINERALYS THERAPEUTICS INC | Healthcare | 0.9% | $15.5m | 408,313 | 26% | added |
| 40 | AM6 AMICUS THERAPEUTICS INC | 0.9% | $15.3m | 1,947,374 | -1% | reduced | |
| 41 | XBI SPDR SERIES TRUST | 0.9% | $15.2m | 151,750 | 0% | held | |
| 42 | ACLXGBX ARCELLX INC | 0.9% | $14.7m | 178,982 | -4% | reduced | |
| 43 | SMMT SUMMIT THERAPEUTICS INC | Healthcare | 0.9% | $14.7m | 710,000 | 0% | held |
| 44 | COGT COGENT BIOSCIENCES INC | Healthcare | 0.8% | $14.5m | 1,008,308 | 26% | added |
| 45 | ELVN ENLIVEN THERAPEUTICS INC | Healthcare | 0.8% | $14.0m | 686,107 | -2% | reduced |
| 46 | ZBIO ZENAS BIOPHARMA INC | 0.8% | $12.9m | 580,677 | -9% | reduced | |
| 47 | NBIX NEUROCRINE BIOSCIENCES INC | Healthcare | 0.7% | $12.6m | 89,750 | 1% | added |
| 48 | ARDX ARDELYX INC | Healthcare | 0.7% | $12.6m | 2,286,273 | 0% | held |
| 49 | DHR DANAHER CORPORATION | Healthcare | 0.7% | $12.2m | 61,500 | 4% | added |
| 50 | LENZ LENZ THERAPEUTICS INC | Healthcare | 0.6% | $11.0m | 236,227 | 181% | added |
Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.