Sphera Funds Management Ltd. 13F holdings, Q4 2025
Holdings as of December 31, 2025 · filings on SEC EDGAR · latest filing →
Sphera Funds Management Ltd. disclosed 94 US equity positions worth $478.5m in its Q4 2025 13F filing. The largest position was TEVA at 7.3% of the reported book, followed by BIIB and MLYS. Against the Q3 2025 filing, it opened 6 new positions, added to 25 and reduced 13 among the top 50 holdings.
What did Sphera Funds Management Ltd. own in Q4 2025? Top 50 positions
| # | Stock | Sector | Weight | Value | Shares | Δ shares | vs Q3 2025 |
|---|---|---|---|---|---|---|---|
| 1 | TEVA TEVA PHARMACEUTICAL INDS LTD | Healthcare | 7.3% | $35.1m | 1,123,525 | -25% | reduced |
| 2 | BIIB BIOGEN INC | Healthcare | 3.5% | $16.7m | 94,738 | 15% | added |
| 3 | MLYS MINERALYS THERAPEUTICS INC | Healthcare | 3.4% | $16.3m | 449,003 | 104% | added |
| 4 | SNDX SYNDAX PHARMACEUTICALS INC | Healthcare | 3.3% | $16.0m | 762,563 | 97% | added |
| 5 | NVMI NOVA LTD | Technology | 3.3% | $15.7m | 47,846 | 9% | added |
| 6 | TSEM TOWER SEMICONDUCTOR LTD | Technology | 3.0% | $14.4m | 122,513 | -61% | reduced |
| 7 | COGT COGENT BIOSCIENCES INC | Healthcare | 2.8% | $13.4m | 378,500 | 284% | added |
| 8 | AZN ASTRAZENECA PLC | Healthcare | 2.6% | $12.4m | 135,060 | 0% | held |
| 9 | SNY SANOFI SA | 2.4% | $11.6m | 239,515 | 9% | added | |
| 10 | LLY ELI LILLY & CO | Healthcare | 2.0% | $9.7m | 9,040 | -10% | reduced |
| 11 | AM6 AMICUS THERAPEUTICS INC | 2.0% | $9.4m | 658,377 | -34% | reduced | |
| 12 | IMTX IMMATICS N.V | Healthcare | 1.9% | $9.0m | 861,105 | 48% | added |
| 13 | BMRN BIOMARIN PHARMACEUTICAL INC | Healthcare | 1.8% | $8.7m | 147,000 | – | new |
| 14 | BBIO BRIDGEBIO PHARMA INC | Healthcare | 1.7% | $8.2m | 107,746 | 164% | added |
| 15 | ORIC ORIC PHARMACEUTICALS INC | Healthcare | 1.7% | $8.2m | 1,004,378 | 133% | added |
| 16 | DYN DYNE THERAPEUTICS INC | Healthcare | 1.6% | $7.7m | 392,894 | -8% | reduced |
| 17 | TRVI TREVI THERAPEUTICS INC | Healthcare | 1.6% | $7.5m | 598,534 | -7% | reduced |
| 18 | JNJ JOHNSON & JOHNSON | Healthcare | 1.5% | $7.4m | 35,831 | -12% | reduced |
| 19 | SVRA SAVARA INC | Healthcare | 1.5% | $7.1m | 1,178,164 | -13% | reduced |
| 20 | SRRK SCHOLAR ROCK HLDG CORP | Healthcare | 1.5% | $7.0m | 158,265 | – | new |
| 21 | WVE WAVE LIFE SCIENCES LTD | Healthcare | 1.5% | $6.9m | 408,166 | 716% | added |
| 22 | RARE ULTRAGENYX PHARMACEUTICAL IN | Healthcare | 1.4% | $6.9m | 300,623 | -15% | reduced |
| 23 | HELP CYBIN INC | 1.4% | $6.8m | 825,576 | 123% | added | |
| 24 | ANNX ANNEXON INC | Healthcare | 1.4% | $6.6m | 1,316,212 | -27% | reduced |
| 25 | BCRX BIOCRYST PHARMACEUTICALS INC | Healthcare | 1.4% | $6.5m | 837,889 | – | new |
| 26 | CLDX CELLDEX THERAPEUTICS INC NEW | Healthcare | 1.4% | $6.5m | 239,764 | 15% | added |
| 27 | SLNOEUR SOLENO THERAPEUTICS INC | 1.3% | $6.3m | 136,314 | 228% | added | |
| 28 | APLSUSD APELLIS PHARMACEUTICALS INC | 1.3% | $6.3m | 250,961 | 294% | added | |
| 29 | GSK GSK PLC | Healthcare | 1.3% | $6.0m | 122,000 | 0% | held |
| 30 | ENPH ENPHASE ENERGY INC | Technology | 1.2% | $6.0m | 186,500 | 599% | added |
| 31 | NVO NOVO-NORDISK A S | Healthcare | 1.2% | $5.9m | 115,677 | 9% | added |
| 32 | CYTK CYTOKINETICS INC | Healthcare | 1.2% | $5.8m | 91,717 | -43% | reduced |
| 33 | ABBV ABBVIE INC | Healthcare | 1.2% | $5.8m | 25,256 | 0% | held |
| 34 | SEDG SOLAREDGE TECHNOLOGIES INC | Technology | 1.2% | $5.7m | 196,536 | 39% | added |
| 35 | ACAD ACADIA PHARMACEUTICALS INC | Healthcare | 1.2% | $5.7m | 212,202 | 43% | added |
| 36 | VOR VOR BIOPHARMA INC | 1.1% | $5.4m | 410,417 | – | new | |
| 37 | MRK MERCK & CO INC | Healthcare | 1.1% | $5.1m | 48,600 | 0% | held |
| 38 | NVS NOVARTIS AG | Healthcare | 1.1% | $5.1m | 37,000 | 0% | held |
| 39 | FBRX FORTE BIOSCIENCES INC | 1.1% | $5.1m | 185,869 | -61% | reduced | |
| 40 | KOD KODIAK SCIENCES INC | Healthcare | 1.0% | $4.9m | 175,500 | – | new |
| 41 | TNGX TANGO THERAPEUTICS INC | Healthcare | 1.0% | $4.8m | 544,563 | – | new |
| 42 | SOLAREDGE TECHNOLOGIES INC | 1.0% | $4.7m | 4,000,000 | 0% | held | |
| 43 | CATBUSD ASTRIA THERAPEUTICS INC | 1.0% | $4.7m | 355,725 | 42% | added | |
| 44 | MDWD MEDIWOUND LTD | Healthcare | 0.9% | $4.3m | 230,347 | 24% | added |
| 45 | CAMT CAMTEK LTD | Technology | 0.9% | $4.2m | 39,498 | 36% | added |
| 46 | RVMD REVOLUTION MEDICINES INC | Healthcare | 0.9% | $4.2m | 52,500 | -12% | reduced |
| 47 | AMD ADVANCED MICRO DEVICES INC | Technology | 0.8% | $3.9m | 18,040 | 17% | added |
| 48 | CLYM CLIMB BIO INC | 0.8% | $3.7m | 932,247 | 114% | added | |
| 49 | ALPHA COGNITION INC | 0.8% | $3.7m | 567,616 | 68% | added | |
| 50 | ELVN ENLIVEN THERAPEUTICS INC | Healthcare | 0.7% | $3.5m | 226,765 | 36% | added |
Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.