Sio Capital Management, LLC 13F holdings, Q4 2025
Holdings as of December 31, 2025 · filings on SEC EDGAR · latest filing →
Sio Capital Management, LLC disclosed 65 US equity positions worth $603.2m in its Q4 2025 13F filing. The largest position was CELC at 7.9% of the reported book, followed by CI and SNY. Against the Q3 2025 filing, it opened 20 new positions, added to 8 and reduced 15 among the top 50 holdings.
What did Sio Capital Management, LLC own in Q4 2025? Top 50 positions
| # | Stock | Sector | Weight | Value | Shares | Δ shares | vs Q3 2025 |
|---|---|---|---|---|---|---|---|
| 1 | CELC CELCUITY INC | Healthcare | 7.9% | $47.6m | 477,067 | -39% | reduced |
| 2 | CI THE CIGNA GROUP | Healthcare | 7.9% | $47.4m | 172,203 | – | new |
| 3 | SNY SANOFI SA | 7.8% | $47.1m | 971,686 | 73% | added | |
| 4 | MMS MAXIMUS INC | Industrials | 7.2% | $43.2m | 500,304 | -10% | reduced |
| 5 | ZBH ZIMMER BIOMET HOLDINGS INC | Healthcare | 5.7% | $34.7m | 385,642 | – | new |
| 6 | KVUE KENVUE INC | Consumer Defensive | 4.2% | $25.3m | 1,465,442 | 74% | added |
| 7 | OGN ORGANON & CO | Healthcare | 4.1% | $24.5m | 3,421,765 | – | new |
| 8 | ICLR ICON PLC | Healthcare | 3.8% | $23.2m | 127,202 | – | new |
| 9 | WAY WAYSTAR HLDG CORP | Healthcare | 3.3% | $20.1m | 613,725 | – | new |
| 10 | LIVN LIVANOVA PLC | Healthcare | 3.3% | $19.8m | 322,382 | – | new |
| 11 | DNTH DIANTHUS THERAPEUTICS INC | Healthcare | 3.2% | $19.6m | 474,503 | -18% | reduced |
| 12 | BHVN BIOHAVEN LTD | Healthcare | 2.3% | $14.1m | 1,244,764 | – | new |
| 13 | GPCR STRUCTURE THERAPEUTICS INC | Healthcare | 2.3% | $14.0m | 201,500 | – | new |
| 14 | BMRN BIOMARIN PHARMACEUTICAL INC | Healthcare | 2.3% | $13.8m | 232,688 | 3% | added |
| 15 | TYRA TYRA BIOSCIENCES INC | Healthcare | 2.3% | $13.8m | 526,002 | 2% | added |
| 16 | BTSG BRIGHTSPRING HEALTH SVCS INC | Healthcare | 1.9% | $11.5m | 308,010 | – | new |
| 17 | CNC CENTENE CORP DEL | Healthcare | 1.9% | $11.3m | 274,350 | -29% | reduced |
| 18 | CRL CHARLES RIV LABS INTL INC | Healthcare | 1.8% | $11.0m | 54,985 | – | new |
| 19 | TFX TELEFLEX INCORPORATED | Healthcare | 1.8% | $10.6m | 86,876 | 117% | added |
| 20 | AVR ANTERIS TECHNOLOGIES GLOBAL | 1.6% | $9.4m | 1,874,641 | 6% | added | |
| 21 | TARA PROTARA THERAPEUTICS INC | 1.5% | $9.1m | 1,715,394 | – | new | |
| 22 | CROSS CTRY HEALTHCARE INC | 1.4% | $8.7m | 1,068,821 | – | new | |
| 23 | HAE HAEMONETICS CORP MASS | Healthcare | 1.2% | $7.4m | 92,631 | -53% | reduced |
| 24 | ANIP ANI PHARMACEUTICALS INC | Healthcare | 1.1% | $6.9m | 87,272 | 57% | added |
| 25 | AQST AQUESTIVE THERAPEUTICS INC | 1.1% | $6.4m | 993,095 | -34% | reduced | |
| 26 | DRUG BRIGHT MINDS BIOSCIENCES INC | Healthcare | 1.1% | $6.4m | 81,883 | -57% | reduced |
| 27 | EWTX EDGEWISE THERAPEUTICS INC | 1.0% | $5.9m | 237,481 | -23% | reduced | |
| 28 | ABVX ABIVAX SA | 1.0% | $5.8m | 43,124 | – | new | |
| 29 | CRNXGBP CRINETICS PHARMACEUTICALS IN | 1.0% | $5.8m | 124,841 | -29% | reduced | |
| 30 | RAPP RAPPORT THERAPEUTICS INC | 0.9% | $5.6m | 185,265 | 0% | held | |
| 31 | COR CENCORA INC | Healthcare | 0.9% | $5.4m | 15,900 | – | new |
| 32 | MCK MCKESSON CORP | Healthcare | 0.9% | $5.2m | 6,400 | – | new |
| 33 | IRON DISC MEDICINE INC | Healthcare | 0.8% | $4.6m | 57,586 | -80% | reduced |
| 34 | PROQR THERAPEUTICS N V | 0.7% | $4.4m | 2,164,181 | 4% | added | |
| 35 | FULC FULCRUM THERAPEUTICS INC | Healthcare | 0.7% | $4.3m | 382,000 | – | new |
| 36 | SVRA SAVARA INC | Healthcare | 0.6% | $3.7m | 613,888 | -16% | reduced |
| 37 | ORKA ORUKA THERAPEUTICS INC | Healthcare | 0.6% | $3.6m | 118,126 | – | new |
| 38 | VTYXUSD VENTYX BIOSCIENCES INC | 0.6% | $3.5m | 387,751 | -53% | reduced | |
| 39 | PMVP PMV PHARMACEUTICALS INC | 0.5% | $3.3m | 2,636,548 | 0% | held | |
| 40 | SI SHOULDER INNOVATIONS INC | 0.5% | $3.3m | 227,971 | -35% | reduced | |
| 41 | ALGS ALIGOS THERAPEUTICS INC | 0.5% | $3.1m | 335,937 | 0% | held | |
| 42 | VIR VIR BIOTECHNOLOGY INC | Healthcare | 0.5% | $2.9m | 478,343 | 0% | held |
| 43 | ALKS ALKERMES PLC | Healthcare | 0.4% | $2.7m | 95,353 | -86% | reduced |
| 44 | IDYA IDEAYA BIOSCIENCES INC | Healthcare | 0.4% | $2.6m | 75,730 | -39% | reduced |
| 45 | KYMR KYMERA THERAPEUTICS INC | Healthcare | 0.4% | $2.5m | 32,235 | – | new |
| 46 | OVID OVID THERAPEUTICS INC | Healthcare | 0.4% | $2.3m | 1,427,495 | 0% | held |
| 47 | CNTX CONTEXT THERAPEUTICS INC | 0.3% | $2.0m | 1,341,636 | 0% | held | |
| 48 | HYPR HYPERFINE INC | 0.3% | $2.0m | 2,000,000 | – | new | |
| 49 | BBOT BRIDGEBIO ONCOLOGY THERAPEUT | 0.3% | $1.6m | 130,628 | 0% | held | |
| 50 | IBIO IBIO INC | 0.2% | $1.4m | 740,000 | – | new |
Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.