Sio Capital Management, LLC 13F holdings, Q3 2025
Holdings as of September 30, 2025 · filings on SEC EDGAR · latest filing →
Sio Capital Management, LLC disclosed 51 US equity positions worth $395.2m in its Q3 2025 13F filing. The largest position was MMS at 12.9% of the reported book, followed by CELC and SNY. Against the Q2 2025 filing, it opened 15 new positions, added to 6 and reduced 12 among the top 50 holdings.
What did Sio Capital Management, LLC own in Q3 2025? Top 50 positions
| # | Stock | Sector | Weight | Value | Shares | Δ shares | vs Q2 2025 |
|---|---|---|---|---|---|---|---|
| 1 | MMS MAXIMUS INC | Industrials | 12.9% | $50.9m | 557,615 | 2% | added |
| 2 | CELC CELCUITY INC | Healthcare | 9.8% | $38.9m | 786,526 | – | new |
| 3 | SNY SANOFI SA | 6.7% | $26.6m | 562,703 | 200% | added | |
| 4 | DNTH DIANTHUS THERAPEUTICS INC | Healthcare | 5.8% | $22.7m | 577,750 | 145% | added |
| 5 | ALKS ALKERMES PLC | Healthcare | 5.1% | $20.2m | 674,840 | – | new |
| 6 | IRON DISC MEDICINE INC | Healthcare | 4.8% | $18.8m | 284,787 | 0% | held |
| 7 | MRK MERCK & CO INC | Healthcare | 3.8% | $14.9m | 177,300 | 2% | added |
| 8 | HSIC HENRY SCHEIN INC | Healthcare | 3.7% | $14.5m | 219,207 | – | new |
| 9 | CNC CENTENE CORP DEL | Healthcare | 3.5% | $13.8m | 387,600 | 48% | added |
| 10 | KVUE KENVUE INC | Consumer Defensive | 3.5% | $13.7m | 844,000 | – | new |
| 11 | BMRN BIOMARIN PHARMACEUTICAL INC | Healthcare | 3.1% | $12.2m | 225,114 | 0% | held |
| 12 | GSK GSK PLC | Healthcare | 2.9% | $11.6m | 268,873 | – | new |
| 13 | DRUG BRIGHT MINDS BIOSCIENCES INC | Healthcare | 2.9% | $11.6m | 190,764 | -63% | reduced |
| 14 | HAE HAEMONETICS CORP MASS | Healthcare | 2.4% | $9.7m | 198,035 | – | new |
| 15 | AQST AQUESTIVE THERAPEUTICS INC | 2.1% | $8.4m | 1,498,095 | 58% | added | |
| 16 | 4XC1 KALVISTA PHARMACEUTICALS INC | 2.1% | $8.3m | 683,819 | – | new | |
| 17 | AVR ANTERIS TECHNOLOGIES GLOBAL | 2.0% | $8.0m | 1,772,601 | -4% | reduced | |
| 18 | CRNXGBP CRINETICS PHARMACEUTICALS IN | 1.8% | $7.3m | 174,841 | – | new | |
| 19 | TYRA TYRA BIOSCIENCES INC | Healthcare | 1.8% | $7.2m | 514,947 | -36% | reduced |
| 20 | RAPP RAPPORT THERAPEUTICS INC | 1.4% | $5.5m | 185,265 | – | new | |
| 21 | NVCR NOVOCURE LTD | Healthcare | 1.4% | $5.3m | 413,829 | – | new |
| 22 | ANIP ANI PHARMACEUTICALS INC | Healthcare | 1.3% | $5.1m | 55,723 | -51% | reduced |
| 23 | EWTX EDGEWISE THERAPEUTICS INC | 1.3% | $5.0m | 307,181 | -43% | reduced | |
| 24 | TFX TELEFLEX INCORPORATED | Healthcare | 1.2% | $4.9m | 40,057 | – | new |
| 25 | SLP SIMULATIONS PLUS INC | Healthcare | 1.2% | $4.8m | 320,307 | – | new |
| 26 | PROQR THERAPEUTICS N V | 1.1% | $4.4m | 2,075,139 | 0% | held | |
| 27 | SI SHOULDER INNOVATIONS INC | 1.1% | $4.4m | 350,000 | – | new | |
| 28 | PMVP PMV PHARMACEUTICALS INC | 0.9% | $3.7m | 2,636,548 | -29% | reduced | |
| 29 | SEPN SEPTERNA INC | 0.9% | $3.6m | 189,199 | -68% | reduced | |
| 30 | IDYA IDEAYA BIOSCIENCES INC | Healthcare | 0.9% | $3.4m | 124,230 | 0% | held |
| 31 | ALGS ALIGOS THERAPEUTICS INC | 0.8% | $3.3m | 335,937 | 0% | held | |
| 32 | ERAS ERASCA INC | Healthcare | 0.8% | $3.0m | 1,369,748 | 0% | held |
| 33 | VIR VIR BIOTECHNOLOGY INC | Healthcare | 0.7% | $2.7m | 478,343 | 0% | held |
| 34 | SVRA SAVARA INC | Healthcare | 0.7% | $2.6m | 726,851 | 0% | held |
| 35 | VTYXUSD VENTYX BIOSCIENCES INC | 0.7% | $2.6m | 829,178 | -37% | reduced | |
| 36 | NEUROONE MED TECHNOLOGIES CO | 0.5% | $2.1m | 2,360,635 | -33% | reduced | |
| 37 | OVID OVID THERAPEUTICS INC | Healthcare | 0.5% | $1.9m | 1,427,495 | -36% | reduced |
| 38 | BBOT BRIDGEBIO ONCOLOGY THERAPEUT | 0.4% | $1.5m | 130,628 | – | new | |
| 39 | CNTX CONTEXT THERAPEUTICS INC | 0.3% | $1.3m | 1,341,636 | 0% | held | |
| 40 | SENS SENSEONICS HOLDINGS INC | Healthcare | 0.3% | $1.0m | 2,315,749 | -52% | reduced |
| 41 | TELA TELA BIO INC | 0.2% | $948.1k | 636,300 | 0% | held | |
| 42 | AVTX AVALO THERAPEUTICS INC | Healthcare | 0.2% | $917.3k | 72,173 | 0% | held |
| 43 | FHTX FOGHORN THERAPEUTICS INC | Healthcare | 0.2% | $600.9k | 122,889 | 0% | held |
| 44 | MODULAR MED INC | 0.1% | $549.9k | 785,824 | 0% | held | |
| 45 | NYXOAH S A | 0.1% | $233.9k | 50,839 | 0% | held | |
| 46 | BOLD BOUNDLESS BIO INC | 0.1% | $201.3k | 163,679 | 0% | held | |
| 47 | APRE APREA THERAPEUTICS INC | 0.0% | $165.5k | 112,223 | -60% | reduced | |
| 48 | 430 TERNS PHARMACEUTICALS INC | 0.0% | $75.9k | 10,100 | 0% | held | |
| 49 | NXTC NEXTCURE INC | 0.0% | $64.1k | 10,940 | – | new | |
| 50 | ROCKET PHARMACEUTICALS INC | 0.0% | $14.4k | 400,000 | 0% | held |
Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.