Palo Alto Investors LP 13F holdings, Q1 2025
Holdings as of March 31, 2025 · filings on SEC EDGAR · latest filing →
Palo Alto Investors LP disclosed 44 US equity positions worth $525.1m in its Q1 2025 13F filing. The largest position was INSM at 14.3% of the reported book, followed by BMRN and AM6. Against the Q4 2024 filing, it opened 3 new positions, added to 9 and reduced 10 among the top 44 holdings.
What did Palo Alto Investors LP own in Q1 2025? Top 44 positions
| # | Stock | Sector | Weight | Value | Shares | Δ shares | vs Q4 2024 |
|---|---|---|---|---|---|---|---|
| 1 | INSM INSMED INC | Healthcare | 14.3% | $75.3m | 987,153 | -38% | reduced |
| 2 | BMRN BIOMARIN PHARMACEUTICAL INC | Healthcare | 13.3% | $70.1m | 991,207 | -7% | reduced |
| 3 | AM6 AMICUS THERAPEUTICS INC | 11.4% | $59.9m | 7,345,002 | -4% | reduced | |
| 4 | ACAD ACADIA PHARMACEUTICALS INC | Healthcare | 8.4% | $44.2m | 2,663,925 | -3% | reduced |
| 5 | UTHR UNITED THERAPEUTICS CORP | Healthcare | 6.2% | $32.4m | 105,228 | -32% | reduced |
| 6 | BIIB BIOGEN INC | Healthcare | 5.3% | $28.0m | 204,923 | 8% | added |
| 7 | ALNY ALNYLAM PHARMACEUTICALS INC | Healthcare | 4.3% | $22.5m | 83,488 | -41% | reduced |
| 8 | PTCT PTC THERAPEUTICS INC | Healthcare | 3.9% | $20.6m | 404,196 | 5% | added |
| 9 | PROTHENA CORP PLC | 3.9% | $20.5m | 1,659,734 | -5% | reduced | |
| 10 | ANAB ANAPTYSBIO INC | Healthcare | 3.6% | $19.0m | 1,020,713 | 21% | added |
| 11 | NVCR NOVOCURE LTD | Healthcare | 3.4% | $17.9m | 1,002,061 | 23% | added |
| 12 | SRPT SAREPTA THERAPEUTICS INC | Healthcare | 2.6% | $13.4m | 210,258 | 0% | held |
| 13 | EHTH EHEALTH INC | Financial Services | 2.1% | $11.3m | 1,684,336 | -10% | reduced |
| 14 | IOVA IOVANCE BIOTHERAPEUTICS INC | Healthcare | 2.0% | $10.7m | 3,211,314 | 6% | added |
| 15 | STAA STAAR SURGICAL CO | Healthcare | 1.8% | $9.3m | 525,017 | 5% | added |
| 16 | AGIO AGIOS PHARMACEUTICALS INC | Healthcare | 1.5% | $8.1m | 276,578 | – | new |
| 17 | ALKS ALKERMES PLC | Healthcare | 1.4% | $7.3m | 221,513 | -23% | reduced |
| 18 | GOSS GOSSAMER BIO INC | Healthcare | 1.3% | $6.9m | 6,276,893 | -0% | held |
| 19 | ALGN ALIGN TECHNOLOGY INC | Healthcare | 1.1% | $6.0m | 37,772 | 0% | held |
| 20 | SNDX SYNDAX PHARMACEUTICALS INC | Healthcare | 1.0% | $5.5m | 444,367 | 10% | added |
| 21 | ACELYRIN INC | 0.8% | $4.4m | 1,792,895 | 0% | held | |
| 22 | DYN DYNE THERAPEUTICS INC | Healthcare | 0.7% | $3.5m | 333,391 | – | new |
| 23 | MIRM MIRUM PHARMACEUTICALS INC | Healthcare | 0.6% | $2.9m | 64,700 | 0% | held |
| 24 | EW EDWARDS LIFESCIENCES CORP | Healthcare | 0.5% | $2.9m | 39,473 | 0% | held |
| 25 | VERVE THERAPEUTICS INC | 0.5% | $2.6m | 575,817 | 0% | held | |
| 26 | BNTX BIONTECH SE-ADR | Healthcare | 0.4% | $2.3m | 25,206 | 0% | held |
| 27 | BCYC BICYCLE THERAPEUTICS PLC-ADR | Healthcare | 0.4% | $2.1m | 248,934 | 0% | held |
| 28 | TVTX TRAVERE THERAPEUTICS INC | Healthcare | 0.4% | $2.0m | 110,719 | 0% | held |
| 29 | TSHA TAYSHA GENE THERAPIES INC | Healthcare | 0.4% | $2.0m | 1,419,468 | 75% | added |
| 30 | NBIX NEUROCRINE BIOSCIENCES INC | Healthcare | 0.3% | $1.5m | 13,334 | – | new |
| 31 | NUVB NUVATION BIO INC | Healthcare | 0.3% | $1.4m | 772,652 | 0% | held |
| 32 | ALDX ALDEYRA THERAPEUTICS INC | Healthcare | 0.2% | $1.3m | 225,465 | 0% | held |
| 33 | KPTI KARYOPHARM THERAPEUTICS INC | Healthcare | 0.2% | $1.2m | 324,032 | -93% | reduced |
| 34 | ACRS ACLARIS THERAPEUTICS INC | Healthcare | 0.2% | $1.2m | 776,028 | 36% | added |
| 35 | HUM HUMANA INC | Healthcare | 0.2% | $1.1m | 3,985 | 0% | held |
| 36 | PYXS PYXIS ONCOLOGY INC | 0.2% | $1.0m | 1,037,421 | 0% | held | |
| 37 | STOK STOKE THERAPEUTICS INC | Healthcare | 0.2% | $837.0k | 125,861 | 0% | held |
| 38 | MNLOUSD VYNE THERAPEUTICS INC PIPE | 0.1% | $703.8k | 445,434 | 0% | held | |
| 39 | ABEO ABEONA THERAPEUTICS INC | Healthcare | 0.1% | $518.2k | 108,865 | 0% | held |
| 40 | URGN UROGEN PHARMA LTD | Healthcare | 0.1% | $271.0k | 24,500 | 0% | held |
| 41 | TIL INSTIL BIO INC | 0.0% | $193.8k | 11,165 | 0% | held | |
| 42 | AKTX AKARI THERAPEUTICS PLC-ADR | 0.0% | $181.1k | 146,024 | 0% | held | |
| 43 | RLMD RELMADA THERAPEUTICS INC | Healthcare | 0.0% | $133.7k | 495,146 | 0% | held |
| 44 | GBIOGBX GENERATION BIO CO | 0.0% | $60.9k | 150,475 | 0% | held |
Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.