Opaleye Management Inc. 13F holdings, Q4 2025
Holdings as of December 31, 2025 · filings on SEC EDGAR · latest filing →
Opaleye Management Inc. disclosed 54 US equity positions worth $757.9m in its Q4 2025 13F filing. The largest position was HROW at 25.2% of the reported book, followed by LQDA and ETON. Against the Q3 2025 filing, it opened 18 new positions, added to 14 and reduced 6 among the top 50 holdings.
What did Opaleye Management Inc. own in Q4 2025? Top 50 positions
| # | Stock | Sector | Weight | Value | Shares | Δ shares | vs Q3 2025 |
|---|---|---|---|---|---|---|---|
| 1 | HROW HARROW HEALTH INC | 25.2% | $191.3m | 3,905,000 | 0% | held | |
| 2 | LQDA LIQUIDIA CORPORATION | Healthcare | 11.2% | $85.0m | 2,435,000 | -7% | reduced |
| 3 | ETON ETON PHARMACEUTICALS INC | 6.4% | $48.4m | 2,860,000 | 0% | held | |
| 4 | RYTM RHYTHM PHARMACEUTICALS INC | Healthcare | 4.7% | $35.3m | 330,000 | -29% | reduced |
| 5 | APGE APOGEE THERAPEUTICS INC | Healthcare | 3.9% | $29.3m | 388,257 | 7% | added |
| 6 | SANUWAVE HEALTH INC | 3.9% | $29.3m | 981,267 | 0% | held | |
| 7 | STOK STOKE THERAPEUTICS INC | Healthcare | 2.9% | $22.1m | 695,000 | 2% | added |
| 8 | OCUL OCULAR THERAPEUTIX INC | Healthcare | 2.6% | $19.4m | 1,595,000 | 0% | held |
| 9 | SOL GEL TECHNOLOGIES | 2.5% | $19.1m | 453,739 | 122% | added | |
| 10 | CGON CG ONCOLOGY INC | Healthcare | 2.2% | $17.0m | 410,000 | 0% | held |
| 11 | TGTX TG THERAPEUTICS INC | Healthcare | 2.1% | $15.9m | 535,000 | 0% | held |
| 12 | IRON DISC MEDICINE INC | Healthcare | 2.1% | $15.9m | 200,000 | 3% | added |
| 13 | RZLT REZOLUTE INC | 2.0% | $14.8m | 6,287,156 | 596% | added | |
| 14 | CBIO CRESCENT BIOPHARMA INC | 1.8% | $14.0m | 1,178,300 | – | new | |
| 15 | ALKS ALKERMES PLC | Healthcare | 1.8% | $13.7m | 490,000 | 9% | added |
| 16 | ALPHA COGNITION INC | 1.8% | $13.5m | 2,070,784 | 1698% | added | |
| 17 | ANNX ANNEXON INC | Healthcare | 1.7% | $13.1m | 2,600,000 | 0% | held |
| 18 | EWTX EDGEWISE THERAPEUTICS INC | 1.6% | $12.4m | 500,000 | 0% | held | |
| 19 | CDXS CODEXIS INC | Healthcare | 1.5% | $11.1m | 6,789,738 | -47% | reduced |
| 20 | PTGX PROTAGONIST THERAPEUTICS INC | Healthcare | 1.2% | $9.2m | 105,000 | 0% | held |
| 21 | GOSS GOSSAMER BIO INC | Healthcare | 1.1% | $8.4m | 2,720,000 | -0% | held |
| 22 | MBX MBX BIOSCIENCES INC | Healthcare | 1.1% | $8.2m | 260,000 | 3% | added |
| 23 | RVMD REVOLUTION MEDICINES INC | Healthcare | 1.1% | $8.0m | 100,000 | 0% | held |
| 24 | XOMA CORP DEL | 1.0% | $7.8m | 292,590 | 15% | added | |
| 25 | DERM JOURNEY MEDICAL CORP | 1.0% | $7.5m | 975,000 | 0% | held | |
| 26 | KPTI KARYOPHARM THERAPEUTICS INC | 0.9% | $6.8m | 930,000 | – | new | |
| 27 | JBIO JADE BIOSCIENCES INC | 0.9% | $6.6m | 427,608 | – | new | |
| 28 | URGN UROGEN PHARMA LTD | Healthcare | 0.8% | $6.3m | 268,423 | – | new |
| 29 | ALMS ALUMIS INC | 0.7% | $5.2m | 535,000 | -20% | reduced | |
| 30 | CATX PERSPECTIVE THERAPEUTICS INC | 0.7% | $5.0m | 1,184,500 | – | new | |
| 31 | VYGR VOYAGER THERAPEUTICS INC | Healthcare | 0.6% | $4.7m | 1,196,904 | – | new |
| 32 | RLMD RELMADA THERAPEUTICS INC | Healthcare | 0.6% | $4.5m | 935,000 | – | new |
| 33 | TECX TECTONIC THERAPEUTICS INC | Healthcare | 0.6% | $4.5m | 214,747 | – | new |
| 34 | PLX PROTALIX BIOTHERAPEUTICS INC | Healthcare | 0.6% | $4.5m | 2,478,176 | -4% | reduced |
| 35 | TRVI TREVI THERAPEUTICS INC | Healthcare | 0.6% | $4.3m | 345,100 | -12% | reduced |
| 36 | FBIO FORTRESS BIOTECH INC | 0.5% | $4.0m | 1,090,000 | – | new | |
| 37 | RCKT ROCKET PHARMACEUTICALS INC | Healthcare | 0.4% | $3.4m | 955,000 | – | new |
| 38 | MGTX MEIRAGTX HOLDINGS PLC | 0.4% | $3.1m | 390,844 | – | new | |
| 39 | RIGL RIGEL PHARMACEUTICALS INC | 0.4% | $3.0m | 70,000 | 85% | added | |
| 40 | ZYME ZYMEWORKS INC | Healthcare | 0.4% | $2.9m | 108,929 | 9% | added |
| 41 | ASSERTIO HOLDINGS INC | 0.3% | $2.6m | 285,000 | – | new | |
| 42 | VTYXUSD VENTYX BIOSCIENCES INC | 0.3% | $2.3m | 251,932 | – | new | |
| 43 | IRD OPUS GENETICS INC | 0.3% | $2.3m | 1,120,000 | 2% | added | |
| 44 | STRO SUTRO BIOPHARMA INC | Healthcare | 0.3% | $2.2m | 190,671 | – | new |
| 45 | CABA CABALETTA BIO INC | Healthcare | 0.3% | $2.0m | 900,000 | 11% | added |
| 46 | ZNTL ZENTALIS PHARMACEUTICALS INC | Healthcare | 0.2% | $1.9m | 1,400,906 | 343% | added |
| 47 | GENERATION BIO CO | 0.2% | $1.8m | 310,000 | – | new | |
| 48 | BBIO BRIDGEBIO PHARMA INC | Healthcare | 0.2% | $1.4m | 18,319 | – | new |
| 49 | ENTA ENANTA PHARMACEUTICALS INC | Healthcare | 0.2% | $1.2m | 75,000 | – | new |
| 50 | QTTB Q32 BIO INC | 0.1% | $708.4k | 213,363 | – | new |
Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.