Avoro Capital Advisors LLC 13F holdings, Q4 2025
Holdings as of December 31, 2025 · filings on SEC EDGAR · latest filing →
Avoro Capital Advisors LLC disclosed 33 US equity positions worth $10.2bn in its Q4 2025 13F filing. The largest position was UTHR at 12.5% of the reported book, followed by ASND and MDGL. Against the Q3 2025 filing, it opened 11 new positions, added to 8 and reduced 6 among the top 33 holdings.
What did Avoro Capital Advisors LLC own in Q4 2025? Top 33 positions
| # | Stock | Sector | Weight | Value | Shares | Δ shares | vs Q3 2025 |
|---|---|---|---|---|---|---|---|
| 1 | UTHR UNITED THERAPEUTICS CORP | Healthcare | 12.5% | $1.3bn | 2,606,060 | 29% | added |
| 2 | ASND ASCENDIS PHARMA | Healthcare | 10.7% | $1.1bn | 5,111,111 | 0% | held |
| 3 | MDGL MADRIGAL PHARMACEUTICALS INC | Healthcare | 10.3% | $1.1bn | 1,807,500 | -1% | reduced |
| 4 | ARGX ARGENX SE | Healthcare | 8.2% | $832.5m | 990,000 | 0% | held |
| 5 | KRYS KRYSTAL BIOTECH INC | Healthcare | 7.0% | $712.2m | 2,888,888 | 4% | added |
| 6 | ARWR ARROWHEAD PHARMACEUTICALS INC | Healthcare | 6.9% | $705.4m | 10,625,000 | -3% | reduced |
| 7 | KYMR KYMERA THERAPEUTICS INC | Healthcare | 5.7% | $581.6m | 7,474,747 | 18% | added |
| 8 | GPCR STRUCTURE THERAPEUTICS INC | Healthcare | 4.5% | $455.9m | 6,555,555 | 27% | added |
| 9 | RNAGBP AVIDITY BIOSCIENCES INC | 3.9% | $393.5m | 5,455,000 | -29% | reduced | |
| 10 | CNTA CENTESSA PHARMACEUTICALS PLC | 3.6% | $364.0m | 14,555,555 | 35% | added | |
| 11 | CELC CELCUITY INC | Healthcare | 3.1% | $310.3m | 3,111,111 | – | new |
| 12 | APLSUSD APELLIS PHARMACEUTICALS INC | 3.0% | $307.0m | 12,222,222 | 0% | held | |
| 13 | VERA VERA THERAPEUTICS INC | Healthcare | 2.9% | $298.2m | 5,888,888 | -5% | reduced |
| 14 | XBI SPDR SERIES TRUST - S&P BIOTECH | 2.5% | $256.1m | 2,100,000 | – | new | |
| 15 | XENE XENON PHARMACEUTICALS INC | Healthcare | 2.4% | $243.1m | 5,424,444 | 0% | held |
| 16 | 430 TERNS PHARMACEUTICALS INC | 1.7% | $175.7m | 4,350,000 | – | new | |
| 17 | RVMD REVOLUTION MEDICINES INC | Healthcare | 1.7% | $172.8m | 2,170,000 | – | new |
| 18 | QURE UNIQURE NV | 1.4% | $147.2m | 6,150,000 | 38% | added | |
| 19 | SLNOEUR SOLENO THERAPEUTICS INC | 1.3% | $134.3m | 2,900,000 | 13% | added | |
| 20 | OCUL OCULAR THERAPEUTIX INC | Healthcare | 1.3% | $130.8m | 10,777,777 | 5% | added |
| 21 | TSHA TAYSHA GENE THERAPIES INC | Healthcare | 1.2% | $119.3m | 21,700,000 | 0% | held |
| 22 | BRD1EUR MIND MEDICINE (MINDMED) INC | 0.7% | $67.0m | 5,000,000 | – | new | |
| 23 | PTCT PTC THERAPEUTICS INC | Healthcare | 0.5% | $52.0m | 685,000 | – | new |
| 24 | VRDN VIRIDIAN THERAPEUTICS INC | Healthcare | 0.5% | $46.7m | 1,500,000 | – | new |
| 25 | ORKA ORUKA THERAPEUTICS INC | Healthcare | 0.4% | $40.4m | 1,333,340 | 0% | held |
| 26 | ALKS ALKERMES PLC | Healthcare | 0.4% | $39.2m | 1,400,000 | -38% | reduced |
| 27 | APGE APOGEE THERAPEUTICS INC | Healthcare | 0.4% | $37.7m | 500,000 | – | new |
| 28 | SEPN SEPTERNA INC | 0.4% | $37.3m | 1,337,500 | 0% | held | |
| 29 | LXEO LEXEO THERAPEUTICS INC | Healthcare | 0.3% | $32.8m | 3,300,000 | – | new |
| 30 | MNKD MANNKIND CORP | Healthcare | 0.2% | $25.2m | 4,444,444 | -1% | reduced |
| 31 | GHRS GH RESEARCH PLC | 0.2% | $22.9m | 1,800,000 | – | new | |
| 32 | INCY INCYTE CORP | Healthcare | 0.1% | $13.3m | 135,000 | – | new |
| 33 | WHWK WHITEHAWK THERAPEUTICS INC | Healthcare | 0.1% | $6.9m | 2,849,402 | 0% | held |
Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.