WhaleCreep

Avidity Partners Management LP 13F holdings, Q1 2021

Hedge fundSEC filingsCompare with another fundHoldings as of 2021-03-31, filed 2021-05-17

Avidity Partners Management LP disclosed 93 US equity positions worth $3.6bn in its Q1 2021 13F filing. Its largest position is ABBV at 6.3% of the reported book, followed by AZN and AVTR. Versus Q4 2020 it opened 36 new positions, added to 33, reduced 14 and exited 37.

$3.6bn
Reported equity book
Sum of the long US equity positions in the filing, at the values filed. Options are excluded.
93
Positions
Distinct securities in the equity book with a reported value above zero. Options are excluded.
6.3%
Largest position
The largest single position as a share of the reported equity book.
34.8%
Top 10 weight
The ten largest positions together, as a share of the reported equity book.
46
Effective positions
1 / HHI of portfolio weights: the number of equal-weight positions the book behaves like.
27
Quarters on file since Q4 2019
Quarters for which this manager's 13F holdings are on record.

Holdings

Against Q4 2020: 36 new, 33 added, 14 reduced, 37 exited

50 of 93
ABBV ABBVIE INCHealthcare6.3%$225m2.08m+53%added
AZN ASTRAZENECA PLCHealthcare5.1%$182m3.65m+59%added
AVTR AVANTOR INCHealthcare4.0%$144m4.99m−24%reduced
MDT Medtronic PlcHealthcare3.4%$121m1.02m+240%added
ARVN ARVINAS INCHealthcare3.2%$116m1.76m−1.5%reduced
ISRG INTUITIVE SURGICAL INCHealthcare2.9%$103m139,400–new
MRVI MARAVAI LIFESCIENCES HLDGS IHealthcare2.7%$98.4m2.76m−20%reduced
CAH CARDINAL HEALTH INCHealthcare2.5%$88.9m1.46m+81%added
SNDX SYNDAX PHARMACEUTICALS INCHealthcare2.4%$86.0m3.85m+16%added
EPIEUR ESSA PHARMA INC–2.3%$82.5m2.84m+11%added
MRTXEUR MIRATI THERAPEUTICS INC–2.3%$81.5m475,700+25%added
SGENUSD SEAGEN INC–2.2%$80.2m577,900–new
EXK EXACT SCIENCES CORPBasic Materials2.2%$78.8m598,000+142%added
NUVB NUVATION BIO INCHealthcare2.2%$78.6m7.52m–new
BIOHAVEN PHARMACTL HLDG CO L no ticker–2.0%$71.8m1.05m+113%added
VRTX VERTEX PHARMACEUTICALS INCHealthcare1.9%$66.8m310,900+111%added
NBP NOVABRIDGE BIOSCIENCESHealthcare1.8%$64.4m1.33m−16%reduced
ARNAEUR ARENA PHARMACEUTICALS INC–1.7%$62.4m898,550+45%added
ALNY ALNYLAM PHARMACEUTICALS INCHealthcare1.7%$60.4m427,969–new
BHC BAUSCH HEALTH COS INCHealthcare1.7%$60.0m1.89m−4.1%reduced
CTLTEUR CATALENT INC–1.6%$59.0m560,000+66%added
ZNTL ZENTALIS PHARMACEUTICALS INCHealthcare1.5%$54.8m1.26m+11%added
HORIZON THERAPEUTICS PUB L no ticker–1.5%$53.5m581,000−50%reduced
2655787D BLUEPRINT MEDICINES CORP–1.5%$53.1m546,000+127%added
ZBH ZIMMER BIOMET HOLDINGS INCHealthcare1.5%$52.2m326,000–new
NBIX NEUROCRINE BIOSCIENCES INCHealthcare1.4%$50.7m521,400+74%added
BBIO BRIDGEBIO PHARMA INCHealthcare1.4%$50.2m815,100–new
CCXIEUR CHEMOCENTRYX INC–1.3%$48.2m940,800+24%added
XLRN ACCELERON PHARMA INC–1.2%$43.8m322,800+8.0%added
TREUR TRILLIUM THERAPEUTICS INC–1.2%$43.1m4.01m+26%added
ABMDEUR ABIOMED INC–1.2%$42.2m132,500–new
NTRA NATERA INCHealthcare1.1%$40.2m395,600−18%reduced
STTK SHATTUCK LABS INCHealthcare1.1%$38.9m1.33m+42%added
INO INOVIO PHARMACEUTICALS INCHealthcare1.0%$37.2m4.00m–new
KDMN KADMON HLDGS INC–1.0%$37.1m9.54m−0.3%held
ATEC ALPHATEC HLDGS INCHealthcare1.0%$36.9m2.33m+26%added
IDYA IDEAYA BIOSCIENCES INCHealthcare1.0%$34.6m1.47m–new
DVAX DYNAVAX TECHNOLOGIES CORP–1.0%$34.4m3.50m−13%reduced
CI THE CIGNA GROUPHealthcare0.9%$32.6m135,000–new
ORTXUSD ORCHARD THERAPEUTICS PLC–0.9%$31.3m4.32m–new
ATHIRA PHARMA INC no ticker–0.9%$30.9m1.68m+61%added
ALDX ALDEYRA THERAPEUTICS INCHealthcare0.8%$30.3m2.55m+78%added
CGEM CULLINAN THERAPEUTICS INCHealthcare0.8%$29.5m707,359–new
HARPOON THERAPEUTICS INC no ticker–0.8%$29.5m1.41m+79%added
ACET ADICET BIO INCHealthcare0.8%$29.2m2.23m–new
SHC SOTERA HEALTH COHealthcare0.8%$29.0m1.16m+66%added
ORGO ORGANOGENESIS HLDGS INCHealthcare0.7%$26.7m1.46m−73%reduced
BLU BELLUS HEALTH INC NEW–0.7%$26.1m6.80m+19%added
KINIKSA PHARMACEUTICALS LTD no ticker–0.7%$24.6m1.33m+38%added
SANA SANA BIOTECHNOLOGY INCHealthcare0.7%$24.5m732,321–new

Exited since Q4 2020

37 rows
LLY ELI LILLY & CO4.6%$137m
DGX QUEST DIAGNOSTICS INC3.2%$94.4m
BMRN BIOMARIN PHARMACEUTICAL INC2.9%$87.1m
CHNGUSD CHANGE HEALTHCARE INC1.9%$57.5m
APLSUSD APELLIS PHARMACEUTICALS INC1.5%$44.3m
SRPT SAREPTA THERAPEUTICS INC1.2%$37.1m
ANIK ANIKA THERAPEUTICS INC1.1%$33.1m
ACAD ACADIA PHARMACEUTICALS INC0.9%$28.2m
ZYME ZYMEWORKS INC0.9%$27.3m
BTAI BIOXCEL THERAPEUTICS INC0.8%$25.3m
ATRC ATRICURE INC0.8%$24.9m
NTLA INTELLIA THERAPEUTICS INC0.6%$16.5m
RETAEUR REATA PHARMACEUTICALS INC0.5%$15.5m
SGRY SURGERY PARTNERS INC0.5%$15.4m
CERT CERTARA INC0.5%$13.6m
STRO SUTRO BIOPHARMA INC0.5%$13.6m
CDXS CODEXIS INC0.4%$13.1m
OLMA OLEMA PHARMACEUTICALS INC0.4%$13.0m
KURA KURA ONCOLOGY INC0.4%$11.4m
TSHA TAYSHA GENE THERAPIES INC0.3%$10.4m
CSTL CASTLE BIOSCIENCES INC0.3%$10.1m
OSH3USD OAK STR HEALTH INC0.3%$9.2m
LGND LIGAND PHARMACEUTICALS INC0.2%$6.2m
OMGBP OUTSET MED INC0.2%$5.7m
OCUL OCULAR THERAPEUTIX INC0.2%$5.2m
FPRX FIVE PRIME THERAPEUTICS INC0.2%$5.1m
PHAT PHATHOM PHARMACEUTICALS INC0.2%$5.1m
BDQM ALBIREO PHARMA INC0.2%$4.7m
PANACEA ACQUISITION CORP no ticker0.1%$3.8m
2662247D ITEOS THERAPEUTICS INC0.1%$3.1m
KROS KEROS THERAPEUTICS INC0.09%$2.8m
RCKT ROCKET PHARMACEUTICALS INC0.09%$2.7m
ACCDUSD ACCOLADE INC0.06%$1.7m
BCAB BIOATLA INC0.06%$1.7m
NRIX NURIX THERAPEUTICS INC0.06%$1.6m
RLAY RELAY THERAPEUTICS INC0.04%$1.2m
INOZYME PHARMA INC no ticker0.01%$200k

Sector mix

  • Healthcare63.1%
  • Unclassified34.7%
  • Basic Materials2.2%

Book over time

Every quarter on file (27)
QuarterPositionsEquity book
Q2 202645$624m
Q1 202645$494m
Q4 202539$347m
Q3 202543$439m
Q2 202555$499m
Q1 202563$485m
Q4 202461$1.0bn
Q3 202481$2.0bn
Q2 202485$2.4bn
Q1 202487$2.8bn
Q4 202372$2.6bn
Q3 202383$2.5bn
Q2 202393$2.9bn
Q1 202383$3.0bn
Q4 202284$4.3bn
Q3 202296$4.6bn
Q2 202282$4.4bn
Q1 202291$4.5bn
Q4 202197$4.7bn
Q3 2021103$3.9bn
Q2 2021112$3.7bn
Q1 202193$3.6bn
Q4 202094$3.0bn
Q3 202066$1.9bn
Q2 202057$1.6bn
Q1 202049$698m
Q4 201933$159m

Where Avidity Partners Management LP was early

46 rows
BTAI BIOXCEL THERAPEUTICS INCQ1 20202 of 560.7%1.3%4Exited by Q1 2021+3.4%
ALEC ALECTOR INCQ1 20205 of 872.5%2.5%2Exited by Q3 2020+1.3%
VSTM VERASTEM INCQ1 20205 of 1001.1%1.1%2Exited by Q3 2020−35%
AXSM AXSOME THERAPEUTICS INCQ1 20208 of 1411.7%2.1%17Exited by Q3 2025+77%
IDYA IDEAYA BIOSCIENCES INCQ2 20201 of 1081.2%2.9%19Exited by Q2 2025+15%
ZNTL ZENTALIS PHARMACEUTICALS INCQ2 20203 of 872.1%4.8%14Exited by Q4 2023−58%
VIR VIR BIOTECHNOLOGY INCQ2 20204 of 1141.6%1.7%11Held at last filing, Q2 2026−75%
LEGN LEGEND BIOTECH CORPQ2 20205 of 1210.3%2.6%14Held at last filing, Q2 2026−32%
NTLA INTELLIA THERAPEUTICS INCQ2 20206 of 1290.6%1.7%16Held at last filing, Q2 2026−20%
SNDX SYNDAX PHARMACEUTICALS INCQ2 20206 of 1271.5%3.5%21Exited by Q3 2025−37%
ARVN ARVINAS INCQ2 20208 of 1212.3%5.1%22Exited by Q4 2025−75%
AVTR AVANTOR INCQ2 20209 of 1841.8%6.2%17Exited by Q2 2025−4.7%
NBP I MABQ3 20202 of 663.4%3.4%5Exited by Q4 2021+54%
NTRA NATERA INCQ3 202010 of 1672.0%6.8%23Exited by Q2 2026+177%
MRVI MARAVAI LIFESCIENCES HLDGS IQ4 20201 of 1163.2%3.3%3Exited by Q3 2021+49%
ATEC ALPHATEC HLDGS INCQ4 20203 of 1020.9%1.1%10Exited by Q4 2023−11%
ORGO ORGANOGENESIS HLDGS INCQ4 20203 of 671.4%1.4%2Exited by Q2 2021+142%
SHC SOTERA HEALTH COQ4 20203 of 1320.6%1.6%5Exited by Q1 2022−14%
STTK SHATTUCK LABS INCQ4 20203 of 651.7%1.7%5Exited by Q1 2022−84%
SGRY SURGERY PARTNERS INCQ4 20205 of 1320.5%3.8%11Exited by Q1 2025−27%
IMCR IMMUNOCORE HLDGS PLCQ1 20212 of 970.7%2.1%15Exited by Q4 2024−27%
NUVB NUVATION BIO INCQ1 20213 of 972.2%2.2%6Exited by Q3 2022−69%
ACET ADICET BIO INCQ1 20217 of 720.8%1.4%5Exited by Q2 2022+53%
CGEM CULLINAN THERAPEUTICS INCQ1 20219 of 920.8%1.2%3Exited by Q4 2024−60%
BBIO BRIDGEBIO PHARMA INCQ1 202113 of 1741.4%1.4%6Held at last filing, Q2 2026+21%
CMPS COMPASS PATHWAYS PLCQ2 20214 of 1071.0%1.0%2Exited by Q4 2021−22%
DOCS DOXIMITY INCQ2 20218 of 1330.2%1.5%3Exited by Q3 2025+5.4%
STVN STEVANATO GROUP S P AQ3 20212 of 621.6%1.6%2Exited by Q1 2022−11%
CRBU CARIBOU BIOSCIENCES INCQ3 20214 of 731.5%1.5%11Exited by Q2 2024−78%
ALT ALTIMMUNE INCQ3 20218 of 1040.6%1.5%10Exited by Q3 2025−66%
KYMR KYMERA THERAPEUTICS INCQ3 20219 of 980.8%2.0%4Exited by Q1 2025−32%
RARE ULTRAGENYX PHARMACEUTICAL INQ3 20219 of 1511.0%3.2%16Exited by Q3 2025−60%
RVMD REVOLUTION MEDICINES INCQ2 20228 of 1640.6%1.9%14Exited by Q2 2026+399%
PLRX PLIANT THERAPEUTICS INCQ3 202210 of 1030.9%2.4%4Exited by Q3 2023−13%
TMDX TRANSMEDICS GROUP INCQ3 202210 of 1080.3%1.2%3Exited by Q1 2025+49%
PCVX VAXCYTE INCQ3 202213 of 1210.3%1.8%9Exited by Q2 2025+57%
BHVN BIOHAVEN LTDQ4 20229 of 1260.5%1.9%10Exited by Q2 2025+73%
ICLR ICON PLCQ4 202215 of 1611.0%1.7%4Exited by Q2 2026−43%
GPCR STRUCTURE THERAPEUTICS INCQ2 20239 of 1140.06%1.8%8Held at last filing, Q2 2026+29%
MLTX MOONLAKE IMMUNOTHERAPEUTICSQ2 202311 of 1210.7%1.8%4Exited by Q2 2026−63%
NMRA NEUMORA THERAPEUTICS INC.Q3 20233 of 751.0%1.3%5Exited by Q4 2024−6.4%
DNTH DIANTHUS THERAPEUTICS INCQ3 20235 of 970.7%35.8%12Held at last filing, Q2 2026+613%
CGON CG ONCOLOGY INCQ1 20242 of 882.3%17.7%10Held at last filing, Q2 2026+62%
JANX JANUX THERAPEUTICS INCQ1 20249 of 1090.5%4.0%5Exited by Q2 2025−28%
ORKA ORUKA THERAPEUTICS INCQ3 20247 of 831.0%11.6%8Held at last filing, Q2 2026+288%
JBIO JADE BIOSCIENCES INCQ2 20252 of 522.3%6.2%5Held at last filing, Q2 2026+122%

Concentration and tenure

6.2%
Median largest position, all quarters
The largest single position as a share of the reported equity book.
39.7%
Median top 10 weight, all quarters
The ten largest positions together, as a share of the reported equity book.
Concentrated
Style, by median largest position
2
Median completed holding, quarters