Spruce Street Capital LP 13F holdings, Q4 2025
Holdings as of December 31, 2025 · filings on SEC EDGAR · latest filing →
Spruce Street Capital LP disclosed 27 US equity positions worth $302.7m in its Q4 2025 13F filing. The largest position was CDTX at 17.0% of the reported book, followed by RLAY and LB PHARMACEUTICALS INC.
What did Spruce Street Capital LP own in Q4 2025? Top 27 positions
| # | Stock | Sector | Weight | Value | Shares | Δ shares | vs prior |
|---|---|---|---|---|---|---|---|
| 1 | CDTX CIDARA THERAPEUTICS INC | 17.0% | $51.3m | 232,269 | – | ||
| 2 | RLAY RELAY THERAPEUTICS INC | Healthcare | 8.3% | $25.2m | 2,984,125 | – | |
| 3 | LB PHARMACEUTICALS INC | 7.4% | $22.4m | 1,005,593 | – | ||
| 4 | RLMD RELMADA THERAPEUTICS INC | Healthcare | 6.5% | $19.7m | 4,086,181 | – | |
| 5 | PCVX VAXCYTE INC | Healthcare | 6.1% | $18.5m | 400,360 | – | |
| 6 | KINIKSA PHARMACEUTICALS INTL | 5.9% | $17.9m | 434,982 | – | ||
| 7 | EYPT EYEPOINT INC | Healthcare | 5.9% | $17.9m | 981,543 | – | |
| 8 | SVRA SAVARA INC | Healthcare | 4.8% | $14.5m | 2,411,093 | – | |
| 9 | ERAS ERASCA INC | Healthcare | 4.8% | $14.5m | 3,889,632 | – | |
| 10 | DNTH DIANTHUS THERAPEUTICS INC | Healthcare | 4.0% | $12.3m | 297,437 | – | |
| 11 | SRZN SURROZEN INC | 3.2% | $9.8m | 432,040 | – | ||
| 12 | OCUL OCULAR THERAPEUTIX INC | Healthcare | 3.1% | $9.5m | 783,999 | – | |
| 13 | SABS SAB BIOTHERAPEUTICS INC | 2.7% | $8.2m | 2,198,502 | – | ||
| 14 | IKT INHIBIKASE THERAPEUTICS INC | 2.4% | $7.3m | 3,581,603 | – | ||
| 15 | ELVN ENLIVEN THERAPEUTICS INC | Healthcare | 2.3% | $6.9m | 446,084 | – | |
| 16 | NERV MINERVA NEUROSCIENCES INC | 2.2% | $6.7m | 1,655,500 | – | ||
| 17 | ABVX ABIVAX SA | 2.2% | $6.6m | 49,119 | – | ||
| 18 | HELP CYBIN INC | 2.1% | $6.3m | 770,000 | – | ||
| 19 | 4XC1 KALVISTA PHARMACEUTICALS INC | 2.1% | $6.3m | 387,968 | – | ||
| 20 | ENTA ENANTA PHARMACEUTICALS INC | Healthcare | 2.0% | $6.1m | 389,687 | – | |
| 21 | ANRO ALTO NEUROSCIENCE INC | Healthcare | 1.3% | $4.0m | 222,844 | – | |
| 22 | LONA ATHIRA PHARMA INC | 1.0% | $3.0m | 393,701 | – | ||
| 23 | CNTA CENTESSA PHARMACEUTICALS PLC | 0.6% | $2.0m | 77,997 | – | ||
| 24 | ALEC ALECTOR INC | Healthcare | 0.6% | $1.7m | 1,117,986 | – | |
| 25 | LXEO LEXEO THERAPEUTICS INC | Healthcare | 0.6% | $1.7m | 175,000 | – | |
| 26 | IPSC CENTURY THERAPEUTICS INC | Healthcare | 0.5% | $1.4m | 1,421,532 | – | |
| 27 | STRO SUTRO BIOPHARMA INC | Healthcare | 0.3% | $874.6k | 75,594 | – |
Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.