Spruce Street Capital LP: 13F holdings, Q2 2026
Hedge fund · SEC EDGAR filings (CIK 2050194) · Explore on the interactive board
Spruce Street Capital LP disclosed 30 US equity positions worth $509.7m in its Q2 2026 13F filing (holdings as of June 30, 2026, filed August 13, 2026). Its largest position is KINIKSA PHARMACEUTICALS INTL at 11.5% of the reported book, followed by RLAY, LB PHARMACEUTICALS INC. The top ten holdings are 70.2% of the book, and the portfolio behaves like about 16 equal-weight positions. Versus the prior filing it opened 5 new positions, added to 8, reduced 1 and exited 3. Note: this manager's most recent filing is 3934 quarters behind the newest quarter on file, so these figures are history rather than current positioning.
What does Spruce Street Capital LP own? Top holdings as of June 30, 2026
Change is measured in shares against the previous filing (Q1 2026), so price moves do not read as decisions. This quarter: 5 new, 8 added, 1 reduced, 3 exited.
| # | Stock | Sector | Weight | Value | Shares | Δ shares | Action |
|---|---|---|---|---|---|---|---|
| 1 | KINIKSA PHARMACEUTICALS INTL | 11.5% | $58.7m | 918,070 | 21% | added | |
| 2 | RLAY RELAY THERAPEUTICS INC | Healthcare | 11.0% | $55.8m | 2,984,125 | 0% | held |
| 3 | LB PHARMACEUTICALS INC | 8.8% | $44.7m | 1,376,159 | 0% | held | |
| 4 | RLMD RELMADA THERAPEUTICS INC | Healthcare | 8.7% | $44.2m | 6,391,328 | 2% | added |
| 5 | ANRO ALTO NEUROSCIENCE INC | Healthcare | 7.0% | $35.7m | 1,353,047 | 2% | added |
| 6 | DNTH DIANTHUS THERAPEUTICS INC | Healthcare | 6.8% | $34.6m | 354,816 | -5% | reduced |
| 7 | ALKS ALKERMES PLC | Healthcare | 5.6% | $28.5m | 543,876 | 71% | added |
| 8 | SVRA SAVARA INC | Healthcare | 4.2% | $21.3m | 3,452,576 | 2% | added |
| 9 | PCVX VAXCYTE INC | Healthcare | 3.5% | $17.8m | 306,047 | 25% | added |
| 10 | ELVN ENLIVEN THERAPEUTICS INC | Healthcare | 3.3% | $16.7m | 329,006 | 0% | held |
| 11 | ENTA ENANTA PHARMACEUTICALS INC | Healthcare | 3.1% | $15.9m | 1,088,731 | 17% | added |
| 12 | CATX PERSPECTIVE THERAPEUTICS INC | 2.5% | $12.6m | 3,693,931 | 41% | added | |
| 13 | INFLARX NV | 2.4% | $12.0m | 5,352,198 | – | new | |
| 14 | SRZN SURROZEN INC | 2.2% | $11.2m | 432,040 | 0% | held | |
| 15 | ALMS ALUMIS INC | Healthcare | 2.2% | $11.0m | 392,574 | 0% | held |
| 16 | IPSC CENTURY THERAPEUTICS INC | Healthcare | 2.0% | $9.9m | 4,059,054 | 0% | held |
| 17 | NERV MINERVA NEUROSCIENCES INC | 1.8% | $9.2m | 1,655,500 | 0% | held | |
| 18 | SABS SAB BIOTHERAPEUTICS INC | 1.7% | $8.6m | 2,198,502 | 0% | held | |
| 19 | ANTX AN2 THERAPEUTICS INC | 1.6% | $8.0m | 1,661,073 | 0% | held | |
| 20 | ERAS ERASCA INC | Healthcare | 1.5% | $7.7m | 422,543 | 0% | held |
| 21 | IKT INHIBIKASE THERAPEUTICS INC | 1.4% | $7.3m | 3,581,603 | 0% | held | |
| 22 | RESEARCH ALLIANCE CORP III | 1.0% | $5.3m | 500,000 | – | new | |
| 23 | HELIX ACQUISITION CORP III | 1.0% | $5.3m | 500,000 | 0% | held | |
| 24 | ZLAB ZAI LAB LTD | Healthcare | 1.0% | $5.3m | 279,110 | – | new |
| 25 | ACHV ACHIEVE LIFE SCIENCE INC | 0.9% | $4.8m | 736,637 | – | new | |
| 26 | LXEO LEXEO THERAPEUTICS INC | Healthcare | 0.8% | $4.3m | 928,593 | 0% | held |
| 27 | ALEC ALECTOR INC | Healthcare | 0.8% | $4.2m | 2,101,068 | 0% | held |
| 28 | LONA LEONABIO INC | 0.7% | $3.6m | 393,701 | 0% | held | |
| 29 | CRVS CORVUS PHARMACEUTICALS INC | Healthcare | 0.7% | $3.5m | 231,585 | 0% | held |
| 30 | JATT II ACQUISITION CORP | 0.4% | $1.8m | 160,000 | – | new |
What did Spruce Street Capital LP sell? Positions exited since the previous filing
| Stock | Prior weight | Prior value |
|---|---|---|
| CNTA CENTESSA PHARMACEUTICALS | 44.7% | $19.5m |
| 4XC1 KALVISTA PHARMACEUTICALS | 41.5% | $18.1m |
| MAZE MAZE THERAPEUTICS INC | 13.7% | $6.0m |
Sector mix
| Sector | Weight |
|---|---|
| Healthcare | 62.1% |
Sectors cover positions whose ticker resolved to a sector; the remainder is unclassified, not cash.
Filing history
How concentrated is Spruce Street Capital LP's portfolio?
Across every quarter Spruce Street Capital LP has filed, its median largest position is 10.9% of the book and its median top-ten weight is 68.0%, which WhaleCreep classifies as concentrated (the gate is a median largest position of 5%). Of 3.0 completed holding spells, the median lasted 1.0 quarters; 30.0 positions are still open and their final length is unknown.