Duquesne Family Office LLC 13F holdings, Q4 2025
Holdings as of December 31, 2025 · latest filing →
Duquesne Family Office LLC disclosed 58 US equity positions worth $4.2bn in its Q4 2025 13F filing. The largest position was NTRA at 13.6% of the reported book, followed by XLF and INSM. Against the Q3 2025 filing, it opened 19 new positions, added to 13 and reduced 16 among the top 50 holdings.
What did Duquesne Family Office LLC own in Q4 2025? Top 50 positions
| # | Stock | Sector | Weight | Value | Shares | Δ shares | vs Q3 2025 |
|---|---|---|---|---|---|---|---|
| 1 | NTRA Natera Inc | Healthcare | 13.6% | $575.3m | 2,511,357 | -22% | reduced |
| 2 | XLF Select Sector Spdr Tr | 7.1% | $301.0m | 5,495,600 | – | new | |
| 3 | INSM Insmed Inc | Healthcare | 6.1% | $257.9m | 1,481,752 | -39% | reduced |
| 4 | RSP Invesco Exchange Traded Fd T | 5.3% | $224.9m | 1,173,925 | – | new | |
| 5 | TEVA Teva Pharmaceutical Inds Ltd | Healthcare | 4.3% | $183.4m | 5,874,870 | -65% | reduced |
| 6 | WWD Woodward Inc | Industrials | 4.2% | $178.7m | 590,930 | -7% | reduced |
| 7 | AMZN Amazon Com Inc | Consumer Cyclical | 4.0% | $170.3m | 737,940 | 69% | added |
| 8 | TSM Taiwan Semiconductor Mfg Ltd | Technology | 3.9% | $165.0m | 543,085 | -29% | reduced |
| 9 | CPNG Coupang Inc | Consumer Cyclical | 3.8% | $159.8m | 6,772,909 | 46% | added |
| 10 | GOOGL Alphabet Inc | Communication Services | 2.9% | $120.5m | 385,000 | 277% | added |
| 11 | SE Sea Ltd | Consumer Cyclical | 2.9% | $120.4m | 944,120 | 244% | added |
| 12 | EWZ Ishares Inc | 2.7% | $112.9m | 3,552,575 | – | new | |
| 13 | Newamsterdam Pharma Company | 2.6% | $107.7m | 3,070,146 | 60% | added | |
| 14 | MELI Mercadolibre Inc | Consumer Cyclical | 2.3% | $95.0m | 47,149 | -19% | reduced |
| 15 | TBBB Bbb Foods Inc | Consumer Defensive | 2.1% | $89.3m | 2,675,152 | 126% | added |
| 16 | QSR Restaurant Brands Intl Inc | Consumer Cyclical | 2.0% | $82.5m | 1,209,000 | 7% | added |
| 17 | COGT Cogent Biosciences Inc | Healthcare | 1.9% | $78.7m | 2,214,470 | 109% | added |
| 18 | AA Alcoa Corp | Basic Materials | 1.7% | $73.1m | 1,376,050 | – | new |
| 19 | ENTG Entegris Inc | Technology | 1.7% | $71.1m | 844,160 | – | new |
| 20 | DOCU Docusign Inc | Technology | 1.7% | $69.7m | 1,019,085 | -40% | reduced |
| 21 | LSCC Lattice Semiconductor Corp | Technology | 1.6% | $68.1m | 925,970 | – | new |
| 22 | BE Bloom Energy Corp | Industrials | 1.5% | $64.3m | 740,545 | – | new |
| 23 | WAB Wabtec | Industrials | 1.5% | $64.1m | 300,110 | -1% | reduced |
| 24 | ROKU Roku Inc | Communication Services | 1.5% | $63.2m | 582,980 | -29% | reduced |
| 25 | FIGR Figure Technology Solutio | Financial Services | 1.5% | $62.9m | 1,539,785 | -27% | reduced |
| 26 | CRH Crh Plc | Basic Materials | 1.4% | $59.3m | 474,955 | 21% | added |
| 27 | OPCH Option Care Health Inc | Healthcare | 1.3% | $55.6m | 1,745,950 | 79% | added |
| 28 | EEM Ishares Tr | 1.2% | $49.4m | 902,500 | -52% | reduced | |
| 29 | DAL Delta Air Lines Inc Del | Industrials | 1.1% | $45.2m | 650,910 | – | new |
| 30 | UAL United Airls Hldgs Inc | Industrials | 0.9% | $39.0m | 348,400 | – | new |
| 31 | STUB Stubhub Hldgs Inc | Communication Services | 0.7% | $31.2m | 2,305,751 | -46% | reduced |
| 32 | ON On Semiconductor Corp | Technology | 0.7% | $29.0m | 536,260 | – | new |
| 33 | Flutter Entmt Plc | 0.6% | $24.8m | 115,245 | 0% | held | |
| 34 | PCT Purecycle Technologies Inc | Industrials | 0.6% | $24.7m | 2,878,434 | 25% | added |
| 35 | AEVA Aeva Technologies Inc | Technology | 0.6% | $24.2m | 1,824,862 | -1% | reduced |
| 36 | GS Goldman Sachs Group Inc | Financial Services | 0.6% | $24.2m | 27,500 | – | new |
| 37 | CLF Cleveland-Cliffs Inc New | Basic Materials | 0.5% | $23.2m | 1,745,655 | -36% | reduced |
| 38 | YPF Ypf Sociedad Anonima | Energy | 0.5% | $21.9m | 606,990 | 429% | added |
| 39 | STM Stmicroelectronics N V | Technology | 0.5% | $20.1m | 773,555 | – | new |
| 40 | U Unity Software Inc | Technology | 0.4% | $18.1m | 410,020 | -54% | reduced |
| 41 | SCCO Southern Copper Corp | Basic Materials | 0.4% | $17.3m | 120,817 | – | new |
| 42 | DAKT Daktronics Inc | Technology | 0.4% | $16.9m | 852,960 | -41% | reduced |
| 43 | RH Rh | Consumer Cyclical | 0.4% | $15.8m | 88,200 | – | new |
| 44 | CMG Chipotle Mexican Grill Inc | Consumer Cyclical | 0.3% | $14.5m | 391,930 | 68% | added |
| 45 | PTGX Protagonist Therapeutics Inc | Healthcare | 0.3% | $13.9m | 159,700 | 0% | held |
| 46 | Z Zillow Group Inc | Communication Services | 0.3% | $13.1m | 192,640 | – | new |
| 47 | CDTX Cidara Therapeutics Inc | 0.3% | $10.9m | 49,495 | – | new | |
| 48 | PM Philip Morris Intl Inc | Consumer Defensive | 0.3% | $10.8m | 67,400 | – | new |
| 49 | AAL American Airls Group Inc | Industrials | 0.2% | $9.8m | 639,785 | – | new |
| 50 | AGX Argan Inc | Industrials | 0.2% | $9.4m | 30,000 | – | new |
Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.