5AM Venture Management, LLC 13F holdings, Q4 2025
Holdings as of December 31, 2025 · filings on SEC EDGAR · latest filing →
5AM Venture Management, LLC disclosed 21 US equity positions worth $318.1m in its Q4 2025 13F filing. The largest position was TRDA at 13.1% of the reported book, followed by CAMP and TYRA. Against the Q3 2025 filing, it opened 1 new position, added to 6 and reduced 2 among the top 21 holdings.
What did 5AM Venture Management, LLC own in Q4 2025? Top 21 positions
| # | Stock | Sector | Weight | Value | Shares | Δ shares | vs Q3 2025 |
|---|---|---|---|---|---|---|---|
| 1 | TRDA ENTRADA THERAPEUTICS INC | 13.1% | $41.7m | 4,056,379 | -5% | reduced | |
| 2 | CAMP CAMP4 THERAPEUTICS CORP | 11.3% | $36.0m | 5,869,091 | 0% | held | |
| 3 | TYRA TYRA BIOSCIENCES INC | Healthcare | 8.5% | $27.1m | 1,029,298 | 10% | added |
| 4 | VRDN VIRIDIAN THERAPEUTICS INC | Healthcare | 7.2% | $22.9m | 736,595 | 0% | held |
| 5 | PHVS PHARVARIS N V | 7.0% | $22.1m | 797,600 | 0% | held | |
| 6 | ERAS ERASCA INC | Healthcare | 6.3% | $20.1m | 5,405,404 | 0% | held |
| 7 | EYPT EYEPOINT INC | Healthcare | 6.0% | $19.2m | 1,050,000 | 0% | held |
| 8 | MPLT MAPLIGHT THERAPEUTICS INC | 5.2% | $16.7m | 950,011 | – | new | |
| 9 | CNTA CENTESSA PHARMACEUTICALS PLC | 4.6% | $14.5m | 580,945 | -15% | reduced | |
| 10 | CLDX CELLDEX THERAPEUTICS INC NEW | Healthcare | 4.2% | $13.5m | 497,270 | 0% | held |
| 11 | TECX TECTONIC THERAPEUTIC INC | Healthcare | 4.0% | $12.7m | 606,660 | 19% | added |
| 12 | ELVN ENLIVEN THERAPEUTICS INC | Healthcare | 3.7% | $11.9m | 772,477 | 0% | held |
| 13 | ARTV ARTIVA BIOTHERAPEUTICS INC | 3.2% | $10.1m | 2,353,304 | 0% | held | |
| 14 | SRZN SURROZEN INC | 2.8% | $8.8m | 387,500 | 25% | added | |
| 15 | BHVN BIOHAVEN LTD | Healthcare | 2.6% | $8.3m | 738,972 | 54% | added |
| 16 | TARA PROTARA THERAPEUTICS INC | 2.3% | $7.3m | 1,369,782 | 71% | added | |
| 17 | GHRS GH RESEARCH PLC | 2.3% | $7.3m | 572,665 | 0% | held | |
| 18 | SKYE SKYE BIOSCIENCE INC | 2.3% | $7.3m | 9,681,763 | 0% | held | |
| 19 | ZNTL ZENTALIS PHARMACEUTICALS INC | Healthcare | 1.7% | $5.3m | 3,947,913 | 706% | added |
| 20 | SLN SILENCE THERAPEUTICS PLC | 0.9% | $2.9m | 476,200 | 0% | held | |
| 21 | RLYB RALLYBIO CORP | 0.8% | $2.5m | 3,630,724 | 0% | held |
Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.