5am Venture Management, LLC: 13F holdings, Q2 2026
Hedge fund · SEC EDGAR filings (CIK 1799883) · Explore on the interactive board
5am Venture Management, LLC disclosed 16 US equity positions worth $287.9m in its Q2 2026 13F filing (holdings as of June 30, 2026, filed August 14, 2026). Its largest position is MPLT at 11.8% of the reported book, followed by TYRA, TRDA. The top ten holdings are 85.6% of the book, and the portfolio behaves like about 12 equal-weight positions. Versus the prior filing it opened 0 new positions, added to 0, reduced 1 and exited 4. Note: this manager's most recent filing is 3934 quarters behind the newest quarter on file, so these figures are history rather than current positioning.
What does 5am Venture Management, LLC own? Top holdings as of June 30, 2026
Change is measured in shares against the previous filing (Q1 2026), so price moves do not read as decisions. This quarter: 0 new, 0 added, 1 reduced, 4 exited.
| # | Stock | Sector | Weight | Value | Shares | Δ shares | Action |
|---|---|---|---|---|---|---|---|
| 1 | MPLT MAPLIGHT THERAPEUTICS INC | 11.8% | $34.0m | 950,011 | 0% | held | |
| 2 | TYRA TYRA BIOSCIENCES INC | Healthcare | 11.4% | $32.9m | 1,029,298 | 0% | held |
| 3 | TRDA ENTRADA THERAPEUTICS INC | 10.4% | $29.9m | 4,056,379 | 0% | held | |
| 4 | PHVS PHARVARIS N V | Healthcare | 9.6% | $27.6m | 797,600 | 0% | held |
| 5 | CAMP CAMP4 THERAPEUTICS CORP | 8.9% | $25.6m | 5,869,091 | 0% | held | |
| 6 | ARTV ARTIVA BIOTHERAPEUTICS INC | 7.9% | $22.8m | 2,353,304 | 0% | held | |
| 7 | TECX TECTONIC THERAPEUTIC INC | Healthcare | 7.2% | $20.9m | 606,660 | 0% | held |
| 8 | ZNTL ZENTALIS PHARMACEUTICALS INC | Healthcare | 6.7% | $19.1m | 3,947,913 | 0% | held |
| 9 | CLDX CELLDEX THERAPEUTICS INC NEW | Healthcare | 6.4% | $18.5m | 497,270 | 0% | held |
| 10 | EYPT EYEPOINT INC | Healthcare | 5.2% | $15.0m | 1,050,000 | 0% | held |
| 11 | BHVN BIOHAVEN LTD | Healthcare | 3.8% | $11.0m | 738,972 | 0% | held |
| 12 | SRZN SURROZEN INC | 2.4% | $7.0m | 271,250 | -30% | reduced | |
| 13 | SKYE SKYE BIOSCIENCE INC | 2.3% | $6.7m | 9,681,763 | 0% | held | |
| 14 | ALXO ALX ONCOLOGY HLDGS INC | Healthcare | 2.2% | $6.3m | 3,057,325 | 0% | held |
| 15 | TARA PROTARA THERAPEUTICS INC | 1.8% | $5.2m | 1,369,782 | 0% | held | |
| 16 | SLN SILENCE THERAPEUTICS PLC | 1.8% | $5.2m | 476,200 | 0% | held |
What did 5am Venture Management, LLC sell? Positions exited since the previous filing
| Stock | Prior weight | Prior value |
|---|---|---|
| ERAS ERASCA INC | 62.6% | $56.4m |
| CNTA CENTESSA PHARMACEUTICALS PLC | 25.6% | $23.1m |
| GHRS GH RESEARCH PLC | 8.9% | $8.1m |
| RLYB RALLYBIO CORP | 2.9% | $2.6m |
Sector mix
| Sector | Weight |
|---|---|
| Healthcare | 52.6% |
Sectors cover positions whose ticker resolved to a sector; the remainder is unclassified, not cash.
Filing history
How concentrated is 5am Venture Management, LLC's portfolio?
Across every quarter 5am Venture Management, LLC has filed, its median largest position is 13.7% of the book and its median top-ten weight is 82.7%, which WhaleCreep classifies as concentrated (the gate is a median largest position of 5%). Of 4.0 completed holding spells, the median lasted 1.0 quarters; 16.0 positions are still open and their final length is unknown.