5AM Venture Management, LLC 13F holdings, Q3 2025
Holdings as of September 30, 2025 · filings on SEC EDGAR · latest filing →
5AM Venture Management, LLC disclosed 25 US equity positions worth $273.0m in its Q3 2025 13F filing. The largest position was SKYE at 13.9% of the reported book, followed by TRDA and PHVS. Against the Q2 2025 filing, it opened 1 new position, added to 1 and reduced 4 among the top 25 holdings.
What did 5AM Venture Management, LLC own in Q3 2025? Top 25 positions
| # | Stock | Sector | Weight | Value | Shares | Δ shares | vs Q2 2025 |
|---|---|---|---|---|---|---|---|
| 1 | SKYE SKYE BIOSCIENCE INC | 13.9% | $38.0m | 9,681,763 | -2% | reduced | |
| 2 | TRDA ENTRADA THERAPEUTICS INC | 9.0% | $24.7m | 4,256,379 | -1% | reduced | |
| 3 | PHVS PHARVARIS N V | 7.3% | $19.9m | 797,600 | 0% | held | |
| 4 | CAMP CAMP4 THERAPEUTICS CORP | 6.4% | $17.6m | 5,869,091 | 100% | added | |
| 5 | CNTA CENTESSA PHARMACEUTICALS PLC | 6.0% | $16.5m | 680,945 | -18% | reduced | |
| 6 | VRDN VIRIDIAN THERAPEUTICS INC | Healthcare | 5.8% | $15.9m | 736,595 | 0% | held |
| 7 | ELVN ENLIVEN THERAPEUTICS INC | Healthcare | 5.8% | $15.8m | 772,477 | 0% | held |
| 8 | EYPT EYEPOINT PHARMACEUTICALS INC | Healthcare | 5.5% | $15.0m | 1,050,000 | 0% | held |
| 9 | DNTH DIANTHUS THERAPEUTICS INC | Healthcare | 5.3% | $14.4m | 365,053 | -63% | reduced |
| 10 | TYRA TYRA BIOSCIENCES INC | Healthcare | 4.8% | $13.1m | 939,298 | 0% | held |
| 11 | CLDX CELLDEX THERAPEUTICS INC NEW | Healthcare | 4.7% | $12.9m | 497,270 | 0% | held |
| 12 | ERAS ERASCA INC | Healthcare | 4.3% | $11.8m | 5,405,404 | 0% | held |
| 13 | PRAX PRAXIS PRECISION MEDICINES I | Healthcare | 3.3% | $9.0m | 170,000 | 0% | held |
| 14 | GHRS GH RESEARCH PLC | 3.0% | $8.2m | 572,665 | 0% | held | |
| 15 | TECX TECTONIC THERAPEUTIC INC | Healthcare | 2.9% | $8.0m | 511,660 | 0% | held |
| 16 | BHVN BIOHAVEN LTD | Healthcare | 2.6% | $7.2m | 478,972 | 0% | held |
| 17 | ARTV ARTIVA BIOTHERAPEUTICS INC | 2.5% | $6.8m | 2,353,304 | 0% | held | |
| 18 | SRZN SURROZEN INC | 1.5% | $4.0m | 310,000 | 0% | held | |
| 19 | TARA PROTARA THERAPEUTICS INC | 1.3% | $3.5m | 800,000 | 0% | held | |
| 20 | ALEC ALECTOR INC | Healthcare | 1.1% | $2.9m | 995,841 | 0% | held |
| 21 | SLN SILENCE THERAPEUTICS PLC | 0.9% | $2.5m | 476,200 | 0% | held | |
| 22 | AVU0 ADVERUM BIOTECHNOLOGIES INC | 0.9% | $2.5m | 541,666 | 0% | held | |
| 23 | RLYB RALLYBIO CORP | 0.7% | $1.8m | 3,630,724 | 0% | held | |
| 24 | ZNTL ZENTALIS PHARMACEUTICALS INC | Healthcare | 0.3% | $739.9k | 490,000 | 0% | held |
| 25 | MRSN MERSANA THERAPEUTICS INC | 0.1% | $405.1k | 52,200 | – | new |
Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.