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RA Capital Management 13F holdings, Q1 2026

Holdings as of March 31, 2026 · filings on SEC EDGAR · latest filing →

RA Capital Management disclosed 85 US equity positions worth $9.5bn in its Q1 2026 13F filing. The largest position was ASND at 24.8% of the reported book, followed by PCVX and RYTM. Against the Q4 2025 filing, it opened 9 new positions, added to 11 and reduced 1 among the top 50 holdings.

← Q4 2025 · Q2 2026 →

What did RA Capital Management own in Q1 2026? Top 50 positions

#StockSectorWeightValueSharesΔ sharesvs Q4 2025
1 ASND ASCENDIS PHARMA A/S - ADR Healthcare 24.8%$2.4bn10,281,496 0% held
2 PCVX VAXCYTE INC Healthcare 7.0%$666.8m11,474,599 7% added
3 RYTM RHYTHM PHARMACEUTICALS INC Healthcare 6.1%$579.8m6,666,837 0% held
4 TYRA TYRA BIOSCIENCES INC Healthcare 4.9%$467.2m12,198,625 0% held
5 SION SIONNA THERAPEUTICS INC 4.2%$397.1m9,905,045 0% held
6 EWTX EDGEWISE THERAPEUTICS INC 3.5%$328.5m10,428,437 0% held
7 NEWAMSTERDAM PHARMA CO NV 3.2%$305.7m9,550,191 0% held
8 NUVALENT INC-A 2.7%$259.6m2,534,145 35% added
9 DNTH DIANTHUS THERAPEUTICS INC Healthcare 2.3%$219.2m2,611,733 62% added
10 MLYS MINERALYS THERAPEUTICS INC Healthcare 2.2%$208.4m7,692,750 5% added
11 SPYGLASS PHARMA INC 2.2%$207.8m8,021,117 new
12 WVE WAVE LIFE SCIENCES LTD Healthcare 2.1%$195.6m26,975,505 48% added
13 SEPN SEPTERNA INC 1.8%$168.1m6,995,858 0% held
14 IRON DISC MEDICINE INC Healthcare 1.7%$156.7m2,450,221 24% added
15 JANX JANUX THERAPEUTICS INC Healthcare 1.6%$155.5m11,189,693 0% held
16 BCRX BIOCRYST PHARMACEUTICALS INC Healthcare 1.6%$150.7m15,827,186 0% held
17 BCAX BICARA THERAPEUTICS INC 1.5%$144.3m7,255,993 4% added
18 CLYM CLIMB BIO INC 1.3%$120.8m11,300,939 0% held
19 PRAX PRAXIS PRECISION MEDICINES I Healthcare 1.3%$120.4m373,787 0% held
20 GHRS GH RESEARCH PLC 1.1%$107.9m7,676,697 0% held
21 ZLAB ZAI LAB LTD-ADR Healthcare 1.1%$107.4m5,707,262 new
22 TSHA TAYSHA GENE THERAPIES INC Healthcare 1.1%$105.3m23,555,648 0% held
23 VOR VOR BIOPHARMA INC 1.0%$96.4m5,404,998 0% held
24 GERN GERON CORP Healthcare 1.0%$95.0m63,771,366 0% held
25 SPRY ARS PHARMACEUTICALS INC Healthcare 0.9%$87.2m10,860,977 0% held
26 SRPT SAREPTA THERAPEUTICS INC Healthcare 0.9%$84.9m3,902,596 new
27 SYRE SPYRE THERAPEUTICS INC 0.9%$81.8m1,621,620 0% held
28 EVMN EVOMMUNE INC 0.8%$80.3m3,494,638 1% added
29 SLDB SOLID BIOSCIENCES INC Healthcare 0.7%$67.2m9,339,978 61% added
30 ARTV ARTIVA BIOTHERAPEUTICS INC 0.7%$63.5m9,853,302 0% held
31 DMRA DAMORA THERAPEUTICS INC Healthcare 0.7%$62.1m2,399,310 new
32 XNCR XENCOR INC Healthcare 0.6%$59.1m4,897,237 new
33 LB PHARMACEUTICALS INC 0.6%$54.5m2,208,604 0% held
34 JBIO JADE BIOSCIENCES INC 0.5%$51.6m3,671,083 0% held
35 ABOS ACUMEN PHARMACEUTICALS INC 0.5%$49.5m20,992,669 41% added
36 4D MOLECULAR THERAPEUTICS IN 0.5%$47.0m5,049,779 -11% reduced
37 FULC FULCRUM THERAPEUTICS INC Healthcare 0.5%$46.4m6,053,960 0% held
38 CAPR CAPRICOR THERAPEUTICS INC Healthcare 0.5%$45.8m1,507,844 0% held
39 IPSC CENTURY THERAPEUTICS INC Healthcare 0.4%$40.1m17,754,430 new
40 OLMA OLEMA PHARMACEUTICALS INC Healthcare 0.4%$38.8m2,600,000 0% held
41 LENZ LENZ THERAPEUTICS INC Healthcare 0.4%$38.2m4,178,823 0% held
42 MNPR MONOPAR THERAPEUTICS INC 0.4%$36.6m667,207 0% held
43 PEPG PEPGEN INC Healthcare 0.4%$35.5m20,064,545 0% held
44 DSGN DESIGN THERAPEUTICS INC Healthcare 0.3%$31.6m2,972,973 103% added
45 MIRM MIRUM PHARMACEUTICALS INC Healthcare 0.3%$29.4m318,554 new
46 BIOA BIOAGE LABS INC 0.3%$28.9m1,650,648 new
47 LXEO LEXEO THERAPEUTICS INC Healthcare 0.3%$28.7m5,000,000 0% held
48 ASMB ASSEMBLY BIOSCIENCES INC Healthcare 0.3%$28.3m1,020,410 0% held
49 RZLT REZOLUTE INC 0.3%$28.0m9,180,000 0% held
50 AKTS AKTIS ONCOLOGY INC 0.3%$26.9m1,503,084 new

Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.