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RA Capital Management 13F holdings, Q4 2024

Holdings as of December 31, 2024 · filings on SEC EDGAR · latest filing →

RA Capital Management disclosed 89 US equity positions worth $7.6bn in its Q4 2024 13F filing. The largest position was ASND at 18.4% of the reported book, followed by PCVX and JANX. Against the Q3 2024 filing, it opened 6 new positions, added to 7 and reduced 10 among the top 50 holdings.

← Q3 2024 · Q1 2025 →

What did RA Capital Management own in Q4 2024? Top 50 positions

#StockSectorWeightValueSharesΔ sharesvs Q3 2024
1 ASND ASCENDIS PHARMA A/S - ADR Healthcare 18.4%$1.4bn10,112,744 4% added
2 PCVX VAXCYTE INC Healthcare 9.4%$711.3m8,689,190 0% held
3 JANX JANUX THERAPEUTICS INC Healthcare 7.3%$555.0m10,365,652 13% added
4 RYTM RHYTHM PHARMACEUTICALS INC Healthcare 4.5%$340.6m6,084,412 0% held
5 LEGN LEGEND BIOTECH CORP-ADR Healthcare 3.2%$244.3m7,506,934 0% held
6 EWTX EDGEWISE THERAPEUTICS INC 3.1%$237.9m8,909,091 0% held
7 NEWAMSTERDAM PHARMA CO NV 3.0%$227.3m8,845,000 10% added
8 WVE WAVE LIFE SCIENCES LTD Healthcare 3.0%$225.2m18,202,009 0% held
9 ARCELLX INC 2.8%$213.8m2,787,327 51% added
10 AVIDITY BIOSCIENCES INC 2.4%$183.2m6,300,408 0% held
11 SEPN SEPTERNA INC 2.1%$160.2m6,995,858 new
12 DYN DYNE THERAPEUTICS INC Healthcare 2.0%$150.3m6,381,144 0% held
13 TYRA TYRA BIOSCIENCES INC Healthcare 2.0%$147.9m10,637,290 2% added
14 RXST RXSIGHT INC Healthcare 1.7%$128.7m3,743,018 -4% reduced
15 BCAX BICARA THERAPEUTICS INC 1.6%$121.2m6,955,993 0% held
16 LENZ LENZ THERAPEUTICS INC Healthcare 1.6%$120.6m4,178,823 0% held
17 SPRY ARS PHARMACEUTICALS INC Healthcare 1.5%$114.6m10,860,977 0% held
18 89BIO INC 1.5%$110.9m14,175,398 0% held
19 XBI SPDR S&P BIOTECH ETF 1.5%$110.6m1,228,240 new
20 GERN GERON CORP Healthcare 1.4%$106.2m30,009,536 -7% reduced
21 CLYM CLIMB BIO INC 1.4%$104.2m31,419,267 0% held
22 ARTV ARTIVA BIOTHERAPEUTICS INC 1.3%$99.3m9,853,302 0% held
23 AXSM AXSOME THERAPEUTICS INC Healthcare 1.1%$84.6m1,000,000 0% held
24 VRNA VERONA PHARMA PLC - ADR 1.1%$82.1m1,766,830 -65% reduced
25 DAWNGBX DAY ONE BIOPHARMACEUTICALS I 1.0%$72.9m5,755,577 -27% reduced
26 APGE APOGEE THERAPEUTICS INC Healthcare 0.9%$71.1m1,569,491 -20% reduced
27 MLYS MINERALYS THERAPEUTICS INC Healthcare 0.8%$59.7m4,850,984 0% held
28 PRAX PRAXIS PRECISION MEDICINES I Healthcare 0.8%$58.6m761,955 0% held
29 RXRX RECURSION PHARMACEUTICALS-A Healthcare 0.7%$52.2m7,725,096 -50% reduced
30 TOURMALINE BIO INC 0.7%$51.5m2,538,925 0% held
31 ACRV ACRIVON THERAPEUTICS INC 0.7%$50.2m8,340,508 0% held
32 FULC FULCRUM THERAPEUTICS INC Healthcare 0.6%$48.1m10,229,099 0% held
33 TXG 10X GENOMICS INC-CLASS A Healthcare 0.6%$47.1m3,279,401 new
34 GHRS GH RESEARCH PLC 0.6%$46.8m6,686,689 0% held
35 ASTRIA THERAPEUTICS INC 0.6%$45.6m5,105,213 0% held
36 VOR VOR BIOPHARMA INC 0.6%$44.0m39,646,039 74% added
37 GPCR STRUCTURE THERAPEUTICS INC Healthcare 0.5%$41.2m1,517,418 -20% reduced
38 DNTH DIANTHUS THERAPEUTICS INC Healthcare 0.5%$40.7m1,866,400 -20% reduced
39 PEPG PEPGEN INC Healthcare 0.5%$40.5m10,689,545 0% held
40 EVH EVOLENT HEALTH INC - A Healthcare 0.5%$40.2m3,577,197 -58% reduced
41 KURA KURA ONCOLOGY INC Healthcare 0.5%$38.8m4,451,041 new
42 IDYA IDEAYA BIOSCIENCES INC Healthcare 0.5%$34.6m1,347,252 0% held
43 ZLAB ZAI LAB LTD-ADR Healthcare 0.4%$33.9m1,295,040 new
44 CHIMERIX INC 0.4%$30.6m8,800,000 0% held
45 CDTX CIDARA THERAPEUTICS INC 0.4%$29.4m1,092,796 55% added
46 MBX MBX BIOSCIENCES INC Healthcare 0.4%$27.9m1,511,334 0% held
47 NKTX NKARTA INC Healthcare 0.4%$26.9m10,805,129 0% held
48 ABOS ACUMEN PHARMACEUTICALS INC 0.3%$25.7m14,932,063 0% held
49 4D MOLECULAR THERAPEUTICS IN 0.3%$25.4m4,563,211 -10% reduced
50 NRIX NURIX THERAPEUTICS INC Healthcare 0.3%$25.1m1,333,333 new

Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.