WhaleCreep

RA Capital Management, L.P. 13F holdings, Q1 2023

Hedge fundSEC filingsCompare with another fundHoldings as of 2023-03-31, filed 2023-05-15

RA Capital Management, L.P. disclosed 59 US equity positions worth $4.4bn in its Q1 2023 13F filing. Its largest position is ASND at 16.9% of the reported book, followed by PCVX and DICE THERAPEUTICS INC. Versus Q4 2022 it opened 4 new positions, added to 12, reduced 2 and exited 15.

$4.4bn
Reported equity book
Sum of the long US equity positions in the filing, at the values filed. Options are excluded.
59
Positions
Distinct securities in the equity book with a reported value above zero. Options are excluded.
16.9%
Largest position
The largest single position as a share of the reported equity book.
50.3%
Top 10 weight
The ten largest positions together, as a share of the reported equity book.
20
Effective positions
1 / HHI of portfolio weights: the number of equal-weight positions the book behaves like.
73
Quarters on file since Q4 2007
Quarters for which this manager's 13F holdings are on record.

Holdings

Against Q4 2022: 4 new, 12 added, 2 reduced, 15 exited

50 of 59
ASND ASCENDIS PHARMA A/SHealthcare16.9%$746m6.96m0.0%held
PCVX VAXCYTE INCHealthcare6.2%$273m7.29m+24%added
DICE THERAPEUTICS INC no ticker–5.1%$225m7.86m+15%added
ETNBGBP 89BIO INC–3.9%$174m11.42m+27%added
AEROVATE THERAPEUTICS INC no ticker–3.8%$167m8.26m0.0%held
BIIB BIOGEN INCHealthcare3.4%$148m532,8920.0%held
VRNA VERONA PHARMA PLC–2.9%$127m6.32m0.0%held
CTKB CYTEK BIOSCIENCES INCHealthcare2.8%$123m13.38m0.0%held
VOR VOR BIOPHARMA INCHealthcare2.8%$122m22.75m0.0%held
LEGN LEGEND BIOTECH CORPHealthcare2.7%$117m2.44m0.0%held
TYRA TYRA BIOSCIENCES INCHealthcare2.6%$116m7.24m0.0%held
JANX JANUX THERAPEUTICS INCHealthcare2.4%$105m8.67m0.0%held
PEPG PEPGEN INCHealthcare2.3%$99.5m8.13m0.0%held
RNAGBP AVIDITY BIOSCIENCES INC–2.2%$98.5m6.42m+18%added
RYTM RHYTHM PHARMACEUTICALS INCHealthcare2.2%$98.4m5.52m0.0%held
DAWNGBX DAY ONE BIOPHARMACEUTICALS I–2.1%$94.1m7.04m0.0%held
BLU BELLUS HEALTH INC NEW–2.1%$91.0m12.64m+1.5%added
CUREVAC N V no ticker–1.9%$85.4m12.25m–new
IMGNEUR IMMUNOGEN INC–1.9%$83.9m21.85m0.0%held
WVE WAVE LIFE SCIENCES LTDHealthcare1.7%$74.5m17.20m0.0%held
INBXUSD INHIBRX INC–1.6%$72.7m3.85m0.0%held
GERN GERON CORPHealthcare1.5%$68.5m31.54m+144%added
COGT COGENT BIOSCIENCES INCHealthcare1.5%$64.7m6.00m0.0%held
CLDX CELLDEX THERAPEUTICS INC NEWHealthcare1.4%$62.4m1.73m−16%reduced
ACRV ACRIVON THERAPEUTICS INCHealthcare1.4%$61.0m4.81m0.0%held
2662247D ITEOS THERAPEUTICS INC–1.4%$60.1m4.42m0.0%held
NEWAMSTERDAM PHARMA COMPANY no ticker–1.2%$53.0m4.00m0.0%held
VRDN VIRIDIAN THERAPEUTICS INCHealthcare1.2%$51.1m2.01m+128%added
RXST RXSIGHT INCHealthcare1.2%$50.9m3.05m0.0%held
MLYS MINERALYS THERAPEUTICS INCHealthcare1.1%$49.8m3.18m–new
PLRX PLIANT THERAPEUTICS INCHealthcare1.1%$46.9m1.76m–new
ELVN ENLIVEN THERAPEUTICS INCHealthcare1.1%$46.5m2.12m–new
GHRS GH RESEARCH PLCHealthcare1.0%$44.6m5.58m+14%added
ABOS ACUMEN PHARMACEUTICALS INCHealthcare0.9%$39.7m9.77m0.0%held
CLYM CLIMB BIO INCHealthcare0.9%$38.1m13.15m0.0%held
ANTX AN2 THERAPEUTICS INCHealthcare0.8%$37.2m3.77m0.0%held
NVLSEUR ALPINE IMMUNE SCIENCES INC–0.8%$36.2m4.69m+6.6%added
ACRS ACLARIS THERAPEUTICS INCHealthcare0.8%$35.6m4.40m0.0%held
ICOSAVAX INC no ticker–0.8%$34.6m5.96m0.0%held
FULC FULCRUM THERAPEUTICS INCHealthcare0.7%$33.1m11.61m+22%added
HLVX HILLEVAX INC–0.7%$29.1m1.76m0.0%held
NKTX NKARTA INCHealthcare0.6%$27.7m7.81m0.0%held
KNTEUSD KINNATE BIOPHARMA INC–0.6%$26.7m4.26m0.0%held
NSTGEUR NANOSTRING TECHNOLOGIES INC–0.6%$24.3m2.46m+1608%added
SPRY ARS PHARMACEUTICALS INCHealthcare0.4%$19.6m3.01m0.0%held
RCKT ROCKET PHARMACEUTICALS INCHealthcare0.4%$19.4m1.13m−53%reduced
TNYA TENAYA THERAPEUTICS INCHealthcare0.4%$17.3m6.07m0.0%held
DSGN DESIGN THERAPEUTICS INCHealthcare0.4%$17.1m2.97m0.0%held
SLDB SOLID BIOSCIENCES INCHealthcare0.4%$16.2m3.43m0.0%held
HOWL WEREWOLF THERAPEUTICS INCHealthcare0.4%$16.0m6.14m+43%added

Exited since Q4 2022

15 rows
TVTX TRAVERE THERAPEUTICS INC1.7%$83.8m
AKROEUR AKERO THERAPEUTICS INC1.1%$52.6m
DA32 LIFE SCNCE no ticker0.3%$15.0m
SCPH SCPHARMACEUTICALS INC0.3%$13.3m
IMARA INC no ticker0.3%$13.3m
ARYA SCIENCES ACQUISITN CORP no ticker0.2%$10.1m
CNCEEUR CONCERT PHARMACEUTICALS INC0.1%$6.4m
HEALTH SCIENCES ACQ CORP 2 no ticker0.1%$6.1m
ATHIRA PHARMA INC no ticker0.1%$6.0m
CVRX CVRX INC0.1%$5.0m
DBV TECHNOLOGIES S A no ticker0.06%$3.0m
IOBTQ IO BIOTECH INC0.05%$2.6m
THIRD HARMONIC BIO INC no ticker0.05%$2.3m
698 ACHILLES THERAPEUTICS PLC0.03%$1.4m
IMUX IMMUNIC INC0.02%$885k

Sector mix

  • Healthcare66.3%
  • Unclassified33.7%

Book over time

Every quarter on file (73)
QuarterPositionsEquity book
Q2 202684$11.5bn
Q1 202685$9.4bn
Q4 202571$9.8bn
Q3 202567$8.1bn
Q2 202563$5.9bn
Q1 202585$6.0bn
Q4 202489$7.5bn
Q3 202481$8.7bn
Q2 202478$7.6bn
Q1 202476$7.9bn
Q4 202362$6.4bn
Q3 202366$5.1bn
Q2 202354$5.3bn
Q1 202359$4.4bn
Q4 202270$4.9bn
Q3 202281$4.7bn
Q2 202288$3.8bn
Q1 202296$4.6bn
Q4 202197$5.7bn
Q3 202195$7.2bn
Q2 202192$6.2bn
Q1 202182$6.6bn
Q4 202082$7.2bn
Q3 202070$5.5bn
Q2 202057$5.1bn
Q1 202048$3.2bn
Q4 201934$3.3bn
Q3 201932$1.7bn
Q2 201925$1.9bn
Q1 201929$2.3bn
Q4 201825$1.7bn
Q3 201826$1.9bn
Q2 201827$1.5bn
Q1 201831$1.3bn
Q4 201727$1.2bn
Q3 201727$1.1bn
Q2 201722$871m
Q1 201724$815m
Q4 201627$706m
Q3 201630$969m
Q2 201632$722m
Q1 201642$782m
Q4 201537$1.0bn
Q3 201547$696m
Q2 201558$928m
Q1 201556$913m
Q4 201448$777m
Q3 201443$622m
Q2 201424$756m
Q1 201429$973m
Q4 201324$648m
Q3 201331$724m
Q2 201325$616m
Q1 201317$407m
Q4 201219$225m
Q3 201221$198m
Q2 201226$223m
Q1 201223$185m
Q4 201118$124m
Q3 201120$90.3m
Q2 201120$108m
Q1 201121$130m
Q4 201016$101m
Q3 201018$101m
Q1 201021$102m
Q4 200914$75.1m
Q2 200916$107m
Q1 200912$184m
Q4 20088$224m
Q3 200820$329m
Q2 200822$220m
Q1 200817$135m
Q4 200723$159m

Where RA Capital Management, L.P. was early

110 rows
VRTX VERTEX PHARMACEUTICALS INCQ1 20082 of 16012.5%12.5%7Exited by Q4 2014+370%
AMAG AMAG PHARMACEUTICALS INCQ2 20081 of 693.4%9.2%7Exited by Q3 2010+2.4%
GILD GILEAD SCIENCES INCQ4 20087 of 1810.7%15.8%6Exited by Q2 2020+192%
BSTC BIOSPECIFICS TECHNOLOGIES COQ1 20091 of 299.0%32.9%7Exited by Q3 2011–
ALXN ALEXION PHARMACEUTICALS INCQ2 20092 of 1476.6%9.6%5Exited by Q2 2011–
UTHR UNITED THERAPEUTICS CORP DELQ2 20092 of 1617.0%7.0%5Exited by Q2 2011+61%
ENZB ENZO BIOCHEM INCQ1 20101 of 400.6%3.9%7Exited by Q1 2014–
ACAD ACADIA PHARMACEUTICALS INCQ1 20111 of 1456.5%21.1%17Exited by Q3 2015+2485%
NVAX NOVAVAX INCQ4 20111 of 1171.0%14.4%24Exited by Q2 2022+192%
SGMOQ SANGAMO THERAPEUTICS INCQ4 20111 of 852.0%13.6%22Exited by Q4 2017+428%
BCRX BIOCRYST PHARMACEUTICALS INCQ1 20121 of 1218.0%11.1%28Held at last filing, Q2 2026+107%
VSTM VERASTEM INCQ1 20121 of 1003.6%3.6%6Exited by Q4 2020−89%
IMMU IMMUNOMEDICS INCQ1 201311 of 1110.6%4.8%6Exited by Q1 2019+492%
ENTA ENANTA PHARMACEUTICALS INCQ2 20131 of 921.3%8.8%8Exited by Q1 2025−68%
INSM INSMED INCQ2 20131 of 1804.7%6.4%9Exited by Q2 2025+538%
OMER OMEROS CORPQ2 20131 of 662.4%2.4%4Exited by Q3 2015+257%
PRTA PROTHENA CORP PLCQ2 20131 of 1011.0%6.7%4Exited by Q2 2014+197%
TXMD THERAPEUTICSMD INCQ2 20131 of 655.5%9.4%13Exited by Q3 2021−61%
PTCT PTC THERAPEUTICS INCQ3 20131 of 1270.9%2.6%7Exited by Q3 2015+124%
TGTX TG THERAPEUTICS INCQ3 20131 of 1140.4%6.8%30Exited by Q1 2022+277%
T8S TESARO INCQ4 20131 of 833.1%3.1%4Exited by Q3 2015+108%
XNCR XENCOR INCQ4 20131 of 1023.8%3.8%13Held at last filing, Q2 2026+76%
MGNX MACROGENICS INCQ4 201310 of 1040.8%2.6%16Held at last filing, Q2 2026−83%
SCYX SCYNEXIS INCQ2 20141 of 470.9%1.1%4Exited by Q2 2015+3.5%
AKBA AKEBIA THERAPEUTICS INCQ2 20142 of 1032.2%2.2%5Exited by Q3 2017−48%
TENX TENAX THERAPEUTICS INCQ3 20143 of 561.5%1.5%10Exited by Q1 2017−50%
CHRS COHERUS BIOSCIENCES INCQ4 20141 of 1053.3%5.2%6Exited by Q2 2016+30%
AUPH AURINIA PHARMACEUTICALS INCQ4 20142 of 1001.2%1.2%3Exited by Q3 2015−17%
ASND ASCENDIS PHARMA A/SQ1 20151 of 1371.9%29.9%46Held at last filing, Q2 2026+1437%
DVAX DYNAVAX TECHNOLOGIES CORPQ1 20151 of 1166.4%6.4%4Exited by Q1 2020−75%
2655787D BLUEPRINT MEDICINES CORPQ2 20151 of 1472.5%2.7%4Exited by Q2 2016−32%
COLL COLLEGIUM PHARMACEUTICAL INCQ2 20151 of 963.0%4.9%4Exited by Q2 2016+1.7%
MCRB SERES THERAPEUTICS INCQ2 20151 of 751.1%2.5%5Exited by Q3 2021−43%
ARDX ARDELYX INCQ2 20152 of 1143.0%4.4%15Exited by Q3 2021−53%
AIMT AIMMUNE THERAPEUTICS INCQ3 20151 of 742.9%2.9%6Exited by Q1 2017−19%
NTRA NATERA INCQ3 20151 of 1671.2%1.3%6Exited by Q3 2022+227%
ACRS ACLARIS THERAPEUTICS INCQ4 20151 of 1146.8%6.8%15Held at last filing, Q2 2026−80%
WVE WAVE LIFE SCIENCES LTDQ4 20151 of 12311.2%26.3%43Held at last filing, Q2 2026−64%
ONC BEIGENE LTDQ1 20164 of 1040.6%1.1%5Exited by Q2 2017+25%
NKTR NEKTAR THERAPEUTICSQ1 20165 of 1455.6%6.5%4Exited by Q4 2023−96%
PTGX PROTAGONIST THERAPEUTICS INCQ3 20162 of 1361.6%2.1%3Exited by Q2 2017−39%
4XC1 KALVISTA PHARMACEUTICALS INCQ4 20161 of 910.6%1.8%15Exited by Q2 2022+108%
KDMN KADMON HLDGS INCQ3 20173 of 762.0%2.0%2Exited by Q1 2018+8.1%
SCPH SCPHARMACEUTICALS INCQ4 20171 of 642.9%2.9%19Exited by Q1 2023−41%
SPRO SPERO THERAPEUTICS INCQ4 20171 of 441.2%1.2%3Exited by Q3 2018+25%
IFRX INFLARX NVQ4 20172 of 575.0%5.0%8Exited by Q4 2025−94%
SG7 SAGE THERAPEUTICS INCQ4 201714 of 1326.3%6.3%5Exited by Q2 2019−3.4%
SLDB SOLID BIOSCIENCES INCQ1 20181 of 951.5%6.8%34Held at last filing, Q2 2026−91%
IOVA IOVANCE BIOTHERAPEUTICS INCQ1 20186 of 1300.9%1.4%5Exited by Q2 2019−44%
RYTM RHYTHM PHARMACEUTICALS INCQ2 20183 of 1143.1%7.3%33Held at last filing, Q2 2026+255%

Concentration and tenure

18.2%
Median largest position, all quarters
The largest single position as a share of the reported equity book.
70.5%
Median top 10 weight, all quarters
The ten largest positions together, as a share of the reported equity book.
Concentrated
Style, by median largest position
3
Median completed holding, quarters