WhaleCreep

RA Capital Management, L.P. 13F holdings, Q4 2022

Hedge fundSEC filingsCompare with another fundHoldings as of 2022-12-31, filed 2023-02-14

RA Capital Management, L.P. disclosed 70 US equity positions worth $4.9bn in its Q4 2022 13F filing. Its largest position is ASND at 17.2% of the reported book, followed by PCVX and AEROVATE THERAPEUTICS INC. Versus Q3 2022 it opened 9 new positions, added to 16, reduced 11 and exited 20.

$4.9bn
Reported equity book
Sum of the long US equity positions in the filing, at the values filed. Options are excluded.
70
Positions
Distinct securities in the equity book with a reported value above zero. Options are excluded.
17.2%
Largest position
The largest single position as a share of the reported equity book.
50.7%
Top 10 weight
The ten largest positions together, as a share of the reported equity book.
20
Effective positions
1 / HHI of portfolio weights: the number of equal-weight positions the book behaves like.
73
Quarters on file since Q4 2007
Quarters for which this manager's 13F holdings are on record.

Holdings

Against Q3 2022: 9 new, 16 added, 11 reduced, 20 exited

50 of 70
ASND ASCENDIS PHARMA A/SHealthcare17.2%$850m6.96m−8.1%reduced
PCVX VAXCYTE INCHealthcare5.7%$281m5.86m+28%added
AEROVATE THERAPEUTICS INC no ticker–4.9%$242m8.26m0.0%held
DICE THERAPEUTICS INC no ticker–4.3%$214m6.85m+31%added
VRNA VERONA PHARMA PLC–3.3%$165m6.32m+4.4%added
RYTM RHYTHM PHARMACEUTICALS INCHealthcare3.3%$161m5.52m+0.8%added
DAWNGBX DAY ONE BIOPHARMACEUTICALS I–3.1%$152m7.04m0.0%held
VOR VOR BIOPHARMA INCHealthcare3.1%$151m22.75m+105%added
BIIB BIOGEN INCHealthcare3.0%$148m532,892−43%reduced
CTKB CYTEK BIOSCIENCES INCHealthcare2.8%$137m13.38m0.0%held
LEGN LEGEND BIOTECH CORPHealthcare2.5%$122m2.44m+4.2%added
RNAGBP AVIDITY BIOSCIENCES INC–2.5%$121m5.45m+152%added
WVE WAVE LIFE SCIENCES LTDHealthcare2.4%$120m17.20m0.0%held
JANX JANUX THERAPEUTICS INCHealthcare2.3%$114m8.67m0.0%held
ETNBGBP 89BIO INC–2.3%$114m8.96m+15%added
PEPG PEPGEN INCHealthcare2.2%$109m8.13m0.0%held
IMGNEUR IMMUNOGEN INC–2.2%$108m21.85m+0.5%added
BLU BELLUS HEALTH INC NEW–2.1%$102m12.45m+9.4%added
INBXUSD INHIBRX INC–1.9%$95.0m3.85m–new
CLDX CELLDEX THERAPEUTICS INC NEWHealthcare1.9%$92.5m2.08m0.0%held
2662247D ITEOS THERAPEUTICS INC–1.7%$86.3m4.42m0.0%held
TVTX TRAVERE THERAPEUTICS INCHealthcare1.7%$83.8m3.98m−19%reduced
COGT COGENT BIOSCIENCES INCHealthcare1.4%$69.4m6.00m+49%added
ACRS ACLARIS THERAPEUTICS INCHealthcare1.4%$69.3m4.40m0.0%held
FULC FULCRUM THERAPEUTICS INCHealthcare1.4%$69.2m9.51m+36%added
ACRV ACRIVON THERAPEUTICS INCHealthcare1.1%$55.4m4.81m–new
TYRA TYRA BIOSCIENCES INCHealthcare1.1%$55.0m7.24m0.0%held
ABOS ACUMEN PHARMACEUTICALS INCHealthcare1.1%$52.8m9.77m0.0%held
AKROEUR AKERO THERAPEUTICS INC–1.1%$52.6m958,9800.0%held
CLYM CLIMB BIO INCHealthcare1.0%$48.3m13.15m0.0%held
GHRS GH RESEARCH PLCHealthcare1.0%$47.6m4.90m0.0%held
ICOSAVAX INC no ticker–1.0%$47.4m5.96m0.0%held
RCKT ROCKET PHARMACEUTICALS INCHealthcare1.0%$47.1m2.41m+14%added
NKTX NKARTA INCHealthcare0.9%$46.8m7.81m0.0%held
NEWAMSTERDAM PHARMA COMPANY no ticker–0.9%$43.6m4.00m–new
RXST RXSIGHT INCHealthcare0.8%$38.7m3.05m0.0%held
ANTX AN2 THERAPEUTICS INCHealthcare0.7%$36.0m3.77m0.0%held
NVLSEUR ALPINE IMMUNE SCIENCES INC–0.7%$32.3m4.40m+0.9%added
GERN GERON CORPHealthcare0.6%$31.3m12.93m−57%reduced
DSGN DESIGN THERAPEUTICS INCHealthcare0.6%$30.5m2.97m+7.1%added
HLVX HILLEVAX INC–0.6%$29.4m1.76m0.0%held
KNTEUSD KINNATE BIOPHARMA INC–0.5%$26.0m4.26m0.0%held
VRDN VIRIDIAN THERAPEUTICS INCHealthcare0.5%$25.7m880,0000.0%held
SPRY ARS PHARMACEUTICALS INCHealthcare0.5%$25.7m3.01m–new
CELC CELCUITY INCHealthcare0.4%$19.6m1.40m–new
SLDB SOLID BIOSCIENCES INCHealthcare0.4%$18.4m3.43m−72%reduced
DA32 LIFE SCNCE no ticker–0.3%$15.0m1.50m0.0%held
SCPH SCPHARMACEUTICALS INC–0.3%$13.3m1.86m–new
IMARA INC no ticker–0.3%$13.3m3.25m–new
TNYA TENAYA THERAPEUTICS INCHealthcare0.2%$12.2m6.07m+279%added

Exited since Q3 2022

20 rows
FORMA THERAPEUTICS HLDGS INC no ticker3.8%$180m
RLMD RELMADA THERAPEUTICS INC1.6%$74.0m
ENTA ENANTA PHARMACEUTICALS INC1.0%$46.5m
TIL INSTIL BIO INC0.8%$37.1m
VERA VERA THERAPEUTICS INC0.7%$33.6m
ACET ADICET BIO INC0.6%$29.3m
MIST MILESTONE PHARMACEUTICALS IN0.4%$20.6m
PMVP PMV PHARMACEUTICALS INC0.4%$20.4m
RLAY RELAY THERAPEUTICS INC0.3%$16.1m
BCLS ACQUISITION CORP no ticker0.3%$12.5m
PARDES BIOSCIENCES INC no ticker0.2%$11.4m
FRAZIER LIFESCIENCES ACQU CO no ticker0.2%$10.0m
5 01 ACQUISITION CORP no ticker0.2%$7.5m
MAGENTA THERAPEUTICS INC no ticker0.1%$5.1m
SYBX SYNLOGIC INC0.09%$4.4m
PYXS PYXIS ONCOLOGY INC0.03%$1.5m
SNSEEUR SENSEI BIOTHERAPEUTICS INC0.02%$1.1m
BOLT BOLT BIOTHERAPEUTICS INC0.02%$789k
APTINYX INC no ticker0.02%$720k
AGLEUSD AEGLEA BIOTHERAPEUTICS INC0.0%$5.0k

Sector mix

  • Healthcare65.0%
  • Unclassified35.0%

Book over time

Every quarter on file (73)
QuarterPositionsEquity book
Q2 202684$11.5bn
Q1 202685$9.4bn
Q4 202571$9.8bn
Q3 202567$8.1bn
Q2 202563$5.9bn
Q1 202585$6.0bn
Q4 202489$7.5bn
Q3 202481$8.7bn
Q2 202478$7.6bn
Q1 202476$7.9bn
Q4 202362$6.4bn
Q3 202366$5.1bn
Q2 202354$5.3bn
Q1 202359$4.4bn
Q4 202270$4.9bn
Q3 202281$4.7bn
Q2 202288$3.8bn
Q1 202296$4.6bn
Q4 202197$5.7bn
Q3 202195$7.2bn
Q2 202192$6.2bn
Q1 202182$6.6bn
Q4 202082$7.2bn
Q3 202070$5.5bn
Q2 202057$5.1bn
Q1 202048$3.2bn
Q4 201934$3.3bn
Q3 201932$1.7bn
Q2 201925$1.9bn
Q1 201929$2.3bn
Q4 201825$1.7bn
Q3 201826$1.9bn
Q2 201827$1.5bn
Q1 201831$1.3bn
Q4 201727$1.2bn
Q3 201727$1.1bn
Q2 201722$871m
Q1 201724$815m
Q4 201627$706m
Q3 201630$969m
Q2 201632$722m
Q1 201642$782m
Q4 201537$1.0bn
Q3 201547$696m
Q2 201558$928m
Q1 201556$913m
Q4 201448$777m
Q3 201443$622m
Q2 201424$756m
Q1 201429$973m
Q4 201324$648m
Q3 201331$724m
Q2 201325$616m
Q1 201317$407m
Q4 201219$225m
Q3 201221$198m
Q2 201226$223m
Q1 201223$185m
Q4 201118$124m
Q3 201120$90.3m
Q2 201120$108m
Q1 201121$130m
Q4 201016$101m
Q3 201018$101m
Q1 201021$102m
Q4 200914$75.1m
Q2 200916$107m
Q1 200912$184m
Q4 20088$224m
Q3 200820$329m
Q2 200822$220m
Q1 200817$135m
Q4 200723$159m

Where RA Capital Management, L.P. was early

110 rows
VRTX VERTEX PHARMACEUTICALS INCQ1 20082 of 16012.5%12.5%7Exited by Q4 2014+370%
AMAG AMAG PHARMACEUTICALS INCQ2 20081 of 693.4%9.2%7Exited by Q3 2010+2.4%
GILD GILEAD SCIENCES INCQ4 20087 of 1810.7%15.8%6Exited by Q2 2020+192%
BSTC BIOSPECIFICS TECHNOLOGIES COQ1 20091 of 299.0%32.9%7Exited by Q3 2011–
ALXN ALEXION PHARMACEUTICALS INCQ2 20092 of 1476.6%9.6%5Exited by Q2 2011–
UTHR UNITED THERAPEUTICS CORP DELQ2 20092 of 1617.0%7.0%5Exited by Q2 2011+61%
ENZB ENZO BIOCHEM INCQ1 20101 of 400.6%3.9%7Exited by Q1 2014–
ACAD ACADIA PHARMACEUTICALS INCQ1 20111 of 1456.5%21.1%17Exited by Q3 2015+2485%
NVAX NOVAVAX INCQ4 20111 of 1171.0%14.4%24Exited by Q2 2022+192%
SGMOQ SANGAMO THERAPEUTICS INCQ4 20111 of 852.0%13.6%22Exited by Q4 2017+428%
BCRX BIOCRYST PHARMACEUTICALS INCQ1 20121 of 1218.0%11.1%28Held at last filing, Q2 2026+107%
VSTM VERASTEM INCQ1 20121 of 1003.6%3.6%6Exited by Q4 2020−89%
IMMU IMMUNOMEDICS INCQ1 201311 of 1110.6%4.8%6Exited by Q1 2019+492%
ENTA ENANTA PHARMACEUTICALS INCQ2 20131 of 921.3%8.8%8Exited by Q1 2025−68%
INSM INSMED INCQ2 20131 of 1804.7%6.4%9Exited by Q2 2025+538%
OMER OMEROS CORPQ2 20131 of 662.4%2.4%4Exited by Q3 2015+257%
PRTA PROTHENA CORP PLCQ2 20131 of 1011.0%6.7%4Exited by Q2 2014+197%
TXMD THERAPEUTICSMD INCQ2 20131 of 655.5%9.4%13Exited by Q3 2021−61%
PTCT PTC THERAPEUTICS INCQ3 20131 of 1270.9%2.6%7Exited by Q3 2015+124%
TGTX TG THERAPEUTICS INCQ3 20131 of 1140.4%6.8%30Exited by Q1 2022+277%
T8S TESARO INCQ4 20131 of 833.1%3.1%4Exited by Q3 2015+108%
XNCR XENCOR INCQ4 20131 of 1023.8%3.8%13Held at last filing, Q2 2026+76%
MGNX MACROGENICS INCQ4 201310 of 1040.8%2.6%16Held at last filing, Q2 2026−83%
SCYX SCYNEXIS INCQ2 20141 of 470.9%1.1%4Exited by Q2 2015+3.5%
AKBA AKEBIA THERAPEUTICS INCQ2 20142 of 1032.2%2.2%5Exited by Q3 2017−48%
TENX TENAX THERAPEUTICS INCQ3 20143 of 561.5%1.5%10Exited by Q1 2017−50%
CHRS COHERUS BIOSCIENCES INCQ4 20141 of 1053.3%5.2%6Exited by Q2 2016+30%
AUPH AURINIA PHARMACEUTICALS INCQ4 20142 of 1001.2%1.2%3Exited by Q3 2015−17%
ASND ASCENDIS PHARMA A/SQ1 20151 of 1371.9%29.9%46Held at last filing, Q2 2026+1437%
DVAX DYNAVAX TECHNOLOGIES CORPQ1 20151 of 1166.4%6.4%4Exited by Q1 2020−75%
2655787D BLUEPRINT MEDICINES CORPQ2 20151 of 1472.5%2.7%4Exited by Q2 2016−32%
COLL COLLEGIUM PHARMACEUTICAL INCQ2 20151 of 963.0%4.9%4Exited by Q2 2016+1.7%
MCRB SERES THERAPEUTICS INCQ2 20151 of 751.1%2.5%5Exited by Q3 2021−43%
ARDX ARDELYX INCQ2 20152 of 1143.0%4.4%15Exited by Q3 2021−53%
AIMT AIMMUNE THERAPEUTICS INCQ3 20151 of 742.9%2.9%6Exited by Q1 2017−19%
NTRA NATERA INCQ3 20151 of 1671.2%1.3%6Exited by Q3 2022+227%
ACRS ACLARIS THERAPEUTICS INCQ4 20151 of 1146.8%6.8%15Held at last filing, Q2 2026−80%
WVE WAVE LIFE SCIENCES LTDQ4 20151 of 12311.2%26.3%43Held at last filing, Q2 2026−64%
ONC BEIGENE LTDQ1 20164 of 1040.6%1.1%5Exited by Q2 2017+25%
NKTR NEKTAR THERAPEUTICSQ1 20165 of 1455.6%6.5%4Exited by Q4 2023−96%
PTGX PROTAGONIST THERAPEUTICS INCQ3 20162 of 1361.6%2.1%3Exited by Q2 2017−39%
4XC1 KALVISTA PHARMACEUTICALS INCQ4 20161 of 910.6%1.8%15Exited by Q2 2022+108%
KDMN KADMON HLDGS INCQ3 20173 of 762.0%2.0%2Exited by Q1 2018+8.1%
SCPH SCPHARMACEUTICALS INCQ4 20171 of 642.9%2.9%19Exited by Q1 2023−41%
SPRO SPERO THERAPEUTICS INCQ4 20171 of 441.2%1.2%3Exited by Q3 2018+25%
IFRX INFLARX NVQ4 20172 of 575.0%5.0%8Exited by Q4 2025−94%
SG7 SAGE THERAPEUTICS INCQ4 201714 of 1326.3%6.3%5Exited by Q2 2019−3.4%
SLDB SOLID BIOSCIENCES INCQ1 20181 of 951.5%6.8%34Held at last filing, Q2 2026−91%
IOVA IOVANCE BIOTHERAPEUTICS INCQ1 20186 of 1300.9%1.4%5Exited by Q2 2019−44%
RYTM RHYTHM PHARMACEUTICALS INCQ2 20183 of 1143.1%7.3%33Held at last filing, Q2 2026+255%

Concentration and tenure

18.2%
Median largest position, all quarters
The largest single position as a share of the reported equity book.
70.5%
Median top 10 weight, all quarters
The ten largest positions together, as a share of the reported equity book.
Concentrated
Style, by median largest position
3
Median completed holding, quarters