Palo Alto Investors LP 13F holdings, Q2 2026
Holdings as of June 30, 2026 · filings on SEC EDGAR · this is the latest filing on record
Palo Alto Investors LP disclosed 52 US equity positions worth $723.7m in its Q2 2026 13F filing. The largest position was PTCT at 10.4% of the reported book, followed by ACAD and INSM. Against the Q1 2026 filing, it opened 3 new positions, added to 5 and reduced 8 among the top 50 holdings.
What did Palo Alto Investors LP own in Q2 2026? Top 50 positions
| # | Stock | Sector | Weight | Value | Shares | Δ shares | vs Q1 2026 |
|---|---|---|---|---|---|---|---|
| 1 | PTCT PTC THERAPEUTICS INC | Healthcare | 10.4% | $75.0m | 918,846 | -0% | held |
| 2 | ACAD ACADIA PHARMACEUTICALS INC | Healthcare | 10.0% | $72.5m | 2,864,096 | -0% | held |
| 3 | INSM INSMED INC | Healthcare | 6.1% | $44.1m | 413,980 | -0% | held |
| 4 | MIRM MIRUM PHARMACEUTICALS INC | Healthcare | 5.6% | $40.8m | 348,808 | 7% | added |
| 5 | ANAB ANAPTYSBIO INC | Healthcare | 5.6% | $40.7m | 603,489 | -5% | reduced |
| 6 | BMRN BIOMARIN PHARMACEUTICAL INC | Healthcare | 5.4% | $39.1m | 682,777 | -0% | held |
| 7 | DYN DYNE THERAPEUTICS INC | Healthcare | 5.1% | $36.6m | 1,647,521 | -0% | held |
| 8 | UTHR UNITED THERAPEUTICS CORP | Healthcare | 4.7% | $33.9m | 62,587 | -0% | held |
| 9 | IRON DISC MEDICINE INC | Healthcare | 4.2% | $30.5m | 416,646 | 4% | added |
| 10 | BIIB BIOGEN INC | Healthcare | 4.2% | $30.3m | 140,279 | -0% | held |
| 11 | IOVA IOVANCE BIOTHERAPEUTICS INC | Healthcare | 3.0% | $22.0m | 5,296,209 | -17% | reduced |
| 12 | RARE ULTRAGENYX PHARMACEUTICAL IN | Healthcare | 2.8% | $19.9m | 596,495 | 0% | held |
| 13 | NVCR NOVOCURE LTD | Healthcare | 2.7% | $19.4m | 1,280,439 | 0% | held |
| 14 | SNDX SYNDAX PHARMACEUTICALS INC | Healthcare | 2.6% | $18.9m | 864,986 | 0% | held |
| 15 | ANNX ANNEXON INC | Healthcare | 2.3% | $16.8m | 2,948,090 | 0% | held |
| 16 | BCAX BICARA THERAPEUTICS INC | Healthcare | 2.3% | $16.3m | 550,408 | 0% | held |
| 17 | CDNA CAREDX INC | Healthcare | 2.1% | $15.2m | 531,870 | 0% | held |
| 18 | CLDX CELLDEX THERAPEUTICS INC | Healthcare | 2.1% | $14.9m | 399,856 | 35% | added |
| 19 | CMPX COMPASS THERAPEUTICS INC | 1.8% | $12.8m | 5,831,813 | 285% | added | |
| 20 | ALKS ALKERMES PLC | Healthcare | 1.8% | $12.7m | 242,560 | 0% | held |
| 21 | TRAX FIRST TRACKS BIOTHERAPEUTICS | 1.7% | $12.1m | 603,489 | – | new | |
| 22 | PRTA PROTHENA CORP PLC | Healthcare | 1.5% | $11.2m | 1,143,155 | -5% | reduced |
| 23 | TVTX TRAVERE THERAPEUTICS INC | Healthcare | 1.3% | $9.5m | 167,525 | -27% | reduced |
| 24 | TSHA TAYSHA GENE THERAPIES INC | Healthcare | 1.3% | $9.5m | 1,391,382 | 0% | held |
| 25 | ACRS ACLARIS THERAPEUTICS INC | Healthcare | 1.2% | $8.5m | 1,613,430 | 0% | held |
| 26 | AGIO AGIOS PHARMACEUTICALS INC | Healthcare | 1.1% | $7.9m | 213,601 | 0% | held |
| 27 | CAPR CAPRICOR THERAPEUTICS INC | Healthcare | 0.8% | $5.5m | 229,763 | 0% | held |
| 28 | ALGN ALIGN TECHNOLOGY INC | Healthcare | 0.7% | $5.3m | 31,389 | -24% | reduced |
| 29 | ORKA ORUKA THERAPEUTICS INC - Restricted | Healthcare | 0.4% | $3.2m | 33,546 | -44% | reduced |
| 30 | XENE XENON PHARMACEUTICALS INC | Healthcare | 0.4% | $3.1m | 51,345 | 0% | held |
| 31 | NBIX NEUROCRINE BIOSCIENCES INC | Healthcare | 0.4% | $3.1m | 18,117 | 0% | held |
| 32 | EW EDWARDS LIFESCIENCES CORP | Healthcare | 0.4% | $3.0m | 33,640 | 0% | held |
| 33 | STOK STOKE THERAPEUTICS INC | Healthcare | 0.4% | $2.8m | 84,631 | 0% | held |
| 34 | CYTK CYTOKINETICS INC | Healthcare | 0.4% | $2.7m | 32,195 | 0% | held |
| 35 | PYXS PYXIS ONCOLOGY INC | 0.4% | $2.6m | 864,277 | -14% | reduced | |
| 36 | EHTH EHEALTH INC | Financial Services | 0.3% | $2.2m | 1,482,797 | 0% | held |
| 37 | CRSP CRISPR THERAPEUTICS AG | Healthcare | 0.3% | $2.2m | 39,605 | 0% | held |
| 38 | SGMT SAGIMET BIOSCIENCES INC-A | Healthcare | 0.3% | $1.9m | 250,000 | – | new |
| 39 | NUVB NUVATION BIO INC | Healthcare | 0.3% | $1.9m | 326,609 | -36% | reduced |
| 40 | BNTX BIONTECH SE-ADR | Healthcare | 0.3% | $1.8m | 19,614 | 0% | held |
| 41 | CMPS COMPASS PATHWAYS PLC ADR | Healthcare | 0.2% | $1.6m | 115,616 | 0% | held |
| 42 | HUM HUMANA INC | Healthcare | 0.2% | $1.6m | 3,985 | 0% | held |
| 43 | NEWAMSTERDAM PHARMA CO NV | 0.2% | $1.5m | 44,359 | – | new | |
| 44 | VSTM VERASTEM INC | Healthcare | 0.2% | $1.2m | 309,685 | 26% | added |
| 45 | MDGL MADRIGAL PHARMACEUTICALS INC | Healthcare | 0.1% | $959.5k | 1,787 | 0% | held |
| 46 | URGN UROGEN PHARMA LTD | Healthcare | 0.1% | $901.6k | 24,500 | 0% | held |
| 47 | BCYC BICYCLE THERAPEUTICS PLC-ADR | Healthcare | 0.1% | $856.0k | 201,890 | 0% | held |
| 48 | XERS XERIS BIOPHARMA HOLDINGS INC | Healthcare | 0.1% | $826.9k | 104,410 | 0% | held |
| 49 | ABEO ABEONA THERAPEUTICS INC | Healthcare | 0.1% | $672.8k | 108,865 | 0% | held |
| 50 | INSP INSPIRE MEDICAL SYSTEMS INC | Healthcare | 0.1% | $391.3k | 8,772 | 0% | held |
Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.