Palo Alto Investors LP 13F holdings, Q1 2026
Holdings as of March 31, 2026 · filings on SEC EDGAR · latest filing →
Palo Alto Investors LP disclosed 51 US equity positions worth $653.9m in its Q1 2026 13F filing. The largest position was INSM at 10.4% of the reported book, followed by ACAD and PTCT.
What did Palo Alto Investors LP own in Q1 2026? Top 50 positions
| # | Stock | Sector | Weight | Value | Shares | Δ shares | vs prior |
|---|---|---|---|---|---|---|---|
| 1 | INSM INSMED INC | Healthcare | 10.4% | $67.9m | 415,269 | – | |
| 2 | ACAD ACADIA PHARMACEUTICALS INC | Healthcare | 9.8% | $63.9m | 2,872,695 | – | |
| 3 | PTCT PTC THERAPEUTICS INC | Healthcare | 9.6% | $62.8m | 921,607 | – | |
| 4 | BMRN BIOMARIN PHARMACEUTICAL INC | Healthcare | 5.9% | $38.7m | 685,182 | – | |
| 5 | UTHR UNITED THERAPEUTICS CORP | Healthcare | 5.7% | $37.2m | 62,809 | – | |
| 6 | ANAB ANAPTYSBIO INC | Healthcare | 5.4% | $35.4m | 638,161 | – | |
| 7 | MIRM MIRUM PHARMACEUTICALS INC | Healthcare | 4.6% | $30.0m | 325,175 | – | |
| 8 | DYN DYNE THERAPEUTICS INC | Healthcare | 4.6% | $30.0m | 1,652,972 | – | |
| 9 | BIIB BIOGEN INC | Healthcare | 3.9% | $25.8m | 140,719 | – | |
| 10 | IRON DISC MEDICINE INC | Healthcare | 3.9% | $25.7m | 401,719 | – | |
| 11 | IOVA IOVANCE BIOTHERAPEUTICS INC | Healthcare | 3.4% | $22.3m | 6,349,563 | – | |
| 12 | SNDX SYNDAX PHARMACEUTICALS INC | Healthcare | 3.1% | $20.2m | 864,986 | – | |
| 13 | ANNX ANNEXON INC | Healthcare | 2.5% | $16.3m | 2,948,090 | – | |
| 14 | AM6 AMICUS THERAPEUTICS INC | 2.5% | $16.1m | 1,113,045 | – | ||
| 15 | NVCR NOVOCURE LTD | Healthcare | 2.1% | $14.0m | 1,280,439 | – | |
| 16 | RARE ULTRAGENYX PHARMACEUTICAL IN | Healthcare | 1.9% | $12.5m | 596,495 | – | |
| 17 | PRTA PROTHENA CORP PLC | Healthcare | 1.8% | $11.7m | 1,208,568 | – | |
| 18 | BCAX BICARA THERAPEUTICS INC | Healthcare | 1.7% | $10.9m | 550,408 | – | |
| 19 | CLDX CELLDEX THERAPEUTICS INC | Healthcare | 1.4% | $9.4m | 296,408 | – | |
| 20 | CDNA CAREDX INC | Healthcare | 1.4% | $9.2m | 531,870 | – | |
| 21 | ALKS ALKERMES PLC | Healthcare | 1.3% | $8.6m | 242,560 | – | |
| 22 | CMPX COMPASS THERAPEUTICS INC | 1.2% | $8.0m | 1,514,504 | – | ||
| 23 | AGIO AGIOS PHARMACEUTICALS INC | Healthcare | 1.1% | $7.2m | 213,601 | – | |
| 24 | ALGN ALIGN TECHNOLOGY INC | Healthcare | 1.1% | $7.1m | 41,520 | – | |
| 25 | CAPR CAPRICOR THERAPEUTICS INC | Healthcare | 1.1% | $7.0m | 229,763 | – | |
| 26 | TVTX TRAVERE THERAPEUTICS INC | Healthcare | 1.0% | $6.8m | 230,453 | – | |
| 27 | TSHA TAYSHA GENE THERAPIES INC | Healthcare | 1.0% | $6.2m | 1,391,382 | – | |
| 28 | ACRS ACLARIS THERAPEUTICS INC | Healthcare | 0.9% | $6.1m | 1,613,430 | – | |
| 29 | DNLI DENALI THERAPEUTICS INC | Healthcare | 0.7% | $4.5m | 234,582 | – | |
| 30 | XENE XENON PHARMACEUTICALS INC | Healthcare | 0.5% | $3.0m | 51,345 | – | |
| 31 | ORKA ORUKA THERAPEUTICS INC | Healthcare | 0.4% | $2.9m | 59,985 | – | |
| 32 | STOK STOKE THERAPEUTICS INC | Healthcare | 0.4% | $2.8m | 84,631 | – | |
| 33 | EW EDWARDS LIFESCIENCES CORP | Healthcare | 0.4% | $2.7m | 33,640 | – | |
| 34 | NBIX NEUROCRINE BIOSCIENCES INC | Healthcare | 0.4% | $2.4m | 18,117 | – | |
| 35 | NUVB NUVATION BIO INC | Healthcare | 0.3% | $2.2m | 508,846 | – | |
| 36 | CYTK CYTOKINETICS INC | Healthcare | 0.3% | $2.1m | 32,195 | – | |
| 37 | EHTH EHEALTH INC | Financial Services | 0.3% | $1.9m | 1,482,797 | – | |
| 38 | CRSP CRISPR THERAPEUTICS AG | Healthcare | 0.3% | $1.9m | 39,605 | – | |
| 39 | BNTX BIONTECH SE-ADR | Healthcare | 0.3% | $1.7m | 19,614 | – | |
| 40 | PYXS PYXIS ONCOLOGY INC | 0.2% | $1.5m | 1,010,510 | – | ||
| 41 | VSTM VERASTEM INC | Healthcare | 0.2% | $1.3m | 246,093 | – | |
| 42 | BCYC BICYCLE THERAPEUTICS PLC-ADR | Healthcare | 0.1% | $936.8k | 201,890 | – | |
| 43 | MDGL MADRIGAL PHARMACEUTICALS INC | Healthcare | 0.1% | $935.4k | 1,787 | – | |
| 44 | HUM HUMANA INC | Healthcare | 0.1% | $691.0k | 3,985 | – | |
| 45 | CMPS COMPASS PATHWAYS PLC ADR | Healthcare | 0.1% | $639.4k | 115,616 | – | |
| 46 | XERS XERIS BIOPHARMA HOLDINGS INC | Healthcare | 0.1% | $605.6k | 104,410 | – | |
| 47 | ABEO ABEONA THERAPEUTICS INC | Healthcare | 0.1% | $487.7k | 108,865 | – | |
| 48 | INSP INSPIRE MEDICAL SYSTEMS INC | Healthcare | 0.1% | $452.5k | 8,772 | – | |
| 49 | URGN UROGEN PHARMA LTD | Healthcare | 0.1% | $440.5k | 24,500 | – | |
| 50 | PROQR THERAPEUTICS NV | 0.0% | $305.9k | 188,807 | – |
Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.