5AM Venture Management, LLC 13F holdings, Q1 2025
Holdings as of March 31, 2025 · filings on SEC EDGAR · latest filing →
5AM Venture Management, LLC disclosed 31 US equity positions worth $264.4m in its Q1 2025 13F filing. The largest position was TRDA at 15.1% of the reported book, followed by ELVN and DNTH. Against the Q4 2024 filing, it opened 1 new position, added to 0 and reduced 2 among the top 31 holdings.
What did 5AM Venture Management, LLC own in Q1 2025? Top 31 positions
| # | Stock | Sector | Weight | Value | Shares | Δ shares | vs Q4 2024 |
|---|---|---|---|---|---|---|---|
| 1 | TRDA ENTRADA THERAPEUTICS INC | 15.1% | $39.9m | 4,408,379 | 0% | held | |
| 2 | ELVN ENLIVEN THERAPEUTICS INC | Healthcare | 9.8% | $26.0m | 1,322,477 | -19% | reduced |
| 3 | DNTH DIANTHUS THERAPEUTICS INC | Healthcare | 7.1% | $18.6m | 1,027,711 | 0% | held |
| 4 | SKYE SKYE BIOSCIENCE INC | 6.0% | $15.8m | 9,913,168 | 0% | held | |
| 5 | PHVS PHARVARIS N V | 4.7% | $12.5m | 797,600 | 0% | held | |
| 6 | CNTA CENTESSA PHARMACEUTICALS PLC | 4.5% | $11.9m | 830,945 | 0% | held | |
| 7 | CAMP CAMP4 THERAPEUTICS CORP | 4.4% | $11.7m | 2,927,915 | 0% | held | |
| 8 | BHVN BIOHAVEN LTD | Healthcare | 4.4% | $11.5m | 478,972 | 0% | held |
| 9 | MLTX MOONLAKE IMMUNOTHERAPEUTICS | Healthcare | 4.2% | $11.0m | 282,313 | 0% | held |
| 10 | VRDN VIRIDIAN THERAPEUTICS INC | Healthcare | 3.8% | $9.9m | 736,595 | 0% | held |
| 11 | TECX TECTONIC THERAPEUTIC INC | Healthcare | 3.4% | $9.1m | 511,660 | -14% | reduced |
| 12 | CLDX CELLDEX THERAPEUTICS INC NEW | Healthcare | 3.4% | $9.0m | 497,270 | 0% | held |
| 13 | TYRA TYRA BIOSCIENCES INC | Healthcare | 3.3% | $8.7m | 939,298 | 0% | held |
| 14 | ERAS ERASCA INC | Healthcare | 2.8% | $7.4m | 5,405,404 | 0% | held |
| 15 | ARTV ARTIVA BIOTHERAPEUTICS INC | 2.7% | $7.1m | 2,353,304 | 0% | held | |
| 16 | ANAB ANAPTYSBIO INC | Healthcare | 2.5% | $6.7m | 357,733 | 0% | held |
| 17 | PRAX PRAXIS PRECISION MEDICINES I | Healthcare | 2.4% | $6.4m | 170,000 | 0% | held |
| 18 | GHRS GH RESEARCH PLC | 2.4% | $6.3m | 572,665 | 0% | held | |
| 19 | EYPT EYEPOINT PHARMACEUTICALS INC | Healthcare | 2.2% | $5.7m | 1,050,000 | 0% | held |
| 20 | VKTX VIKING THERAPEUTICS INC | Healthcare | 1.7% | $4.6m | 189,593 | 0% | held |
| 21 | VOR VOR BIOPHARMA INC | 1.7% | $4.6m | 6,361,723 | 0% | held | |
| 22 | SRZN SURROZEN INC | 1.4% | $3.6m | 310,000 | – | new | |
| 23 | TARA PROTARA THERAPEUTICS INC | 1.3% | $3.4m | 800,000 | 0% | held | |
| 24 | SCPH SCPHARMACEUTICALS INC | 1.2% | $3.2m | 1,200,647 | 0% | held | |
| 25 | RLYB RALLYBIO CORP | 0.9% | $2.4m | 3,630,724 | 0% | held | |
| 26 | AVU0 ADVERUM BIOTECHNOLOGIES INC | 0.9% | $2.4m | 541,666 | 0% | held | |
| 27 | SLN SILENCE THERAPEUTICS PLC | 0.5% | $1.3m | 476,200 | 0% | held | |
| 28 | ALEC ALECTOR INC | Healthcare | 0.5% | $1.2m | 995,841 | 0% | held |
| 29 | CDTX CIDARA THERAPEUTICS INC | 0.5% | $1.2m | 56,725 | 0% | held | |
| 30 | ZNTL ZENTALIS PHARMACEUTICALS INC | Healthcare | 0.3% | $779.1k | 490,000 | 0% | held |
| 31 | MERSANA THERAPEUTICS INC | 0.2% | $449.2k | 1,305,000 | 0% | held |
Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.