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Propel Bio Management, LLC 13F holdings, Q4 2025

Holdings as of December 31, 2025 · filings on SEC EDGAR · latest filing →

Propel Bio Management, LLC disclosed 20 US equity positions worth $117.1m in its Q4 2025 13F filing. The largest position was PAGPEUR at 20.8% of the reported book, followed by ACHV and PHAT. Against the Q3 2025 filing, it opened 8 new positions, added to 4 and reduced 3 among the top 20 holdings.

← Q3 2025 · Q1 2026 →

What did Propel Bio Management, LLC own in Q4 2025? Top 20 positions

#StockSectorWeightValueSharesΔ sharesvs Q3 2025
1 PAGPEUR PLAINS GP HLDGS L P 20.8%$24.4m1,272,360 0% held
2 ACHV ACHIEVE LIFE SCIENCES INC 16.1%$18.8m3,786,425 0% held
3 PHAT PHATHOM PHARMACEUTICALS INC 10.5%$12.3m740,918 34% added
4 VRDN VIRIDIAN THERAPEUTICS INC Healthcare 7.5%$8.8m282,531 214% added
5 MIST MILESTONE PHARMACEUTICALS 7.1%$8.3m4,118,321 -20% reduced
6 KYTX KYVERNA THERAPEUTICS INC 5.4%$6.3m666,666 – new
7 CMPS COMPASS PATHWAYS PLC Healthcare 5.1%$5.9m861,778 69% added
8 IVA INVENTIVA SA - ADR 4.0%$4.7m1,000,000 – new
9 DCTH DELCATH SYSTEMS INC 3.8%$4.4m438,509 0% held
10 ABEO ABEONA THERAPEUTICS INC Healthcare 3.7%$4.4m830,780 -15% reduced
11 CLDX CELLDEX THERAPEUTICS INC Healthcare 3.6%$4.2m154,300 -0% held
12 NKTR NEKTAR THERAPEUTICS Healthcare 3.0%$3.5m82,822 69% added
13 OCULIS HOLDING AG 2.9%$3.5m172,839 – new
14 SABS SAB BIOTHERAPEUTICS INC 2.1%$2.4m652,881 – new
15 RGNX REGENXBIO INC Healthcare 1.4%$1.7m116,896 – new
16 LONA ATHIRA PHARMA INC 1.0%$1.1m149,279 0% held
17 LENZ LENZ THERAPEUTICS INC Healthcare 0.8%$945.4k59,085 – new
18 AARD AARDVARK THERAPEUTICS INC 0.5%$609.1k46,408 – new
19 ZVRA ZEVRA THERAPEUTICS INC 0.5%$570.6k63,683 -73% reduced
20 KLRS KALARIS THERAPEUTICS INC 0.3%$354.9k42,053 – new

Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.