Opaleye Management Inc. 13F holdings, Q1 2025
Holdings as of March 31, 2025 · filings on SEC EDGAR · latest filing →
Opaleye Management Inc. disclosed 45 US equity positions worth $449.2m in its Q1 2025 13F filing. The largest position was HROW at 23.4% of the reported book, followed by ETON and SANUWAVE HEALTH INC. Against the Q4 2024 filing, it opened 15 new positions, added to 8 and reduced 13 among the top 45 holdings.
What did Opaleye Management Inc. own in Q1 2025? Top 45 positions
| # | Stock | Sector | Weight | Value | Shares | Δ shares | vs Q4 2024 |
|---|---|---|---|---|---|---|---|
| 1 | HROW HARROW HEALTH INC | 23.4% | $105.2m | 3,955,000 | -1% | reduced | |
| 2 | ETON ETON PHARMACEUTICALS INC | 8.2% | $37.0m | 2,852,070 | 0% | held | |
| 3 | SANUWAVE HEALTH INC | 7.7% | $34.4m | 972,002 | – | new | |
| 4 | LQDA LIQUIDIA CORPORATION | Healthcare | 7.4% | $33.3m | 2,260,000 | 33% | added |
| 5 | RYTM RHYTHM PHARMACEUTICALS INC | Healthcare | 5.8% | $26.0m | 490,000 | -2% | reduced |
| 6 | CDXS CODEXIS INC | Healthcare | 5.7% | $25.6m | 9,500,000 | 7% | added |
| 7 | IMNM IMMUNOME INC | Healthcare | 5.3% | $23.9m | 3,550,000 | 74% | added |
| 8 | TGTX TG THERAPEUTICS INC | Healthcare | 4.7% | $21.1m | 535,000 | -76% | reduced |
| 9 | ARVN ARVINAS INC | Healthcare | 3.1% | $13.9m | 1,975,000 | 22% | added |
| 10 | OCUL OCULAR THERAPEUTIX INC | Healthcare | 2.6% | $11.7m | 1,595,000 | -63% | reduced |
| 11 | EWTX EDGEWISE THERAPEUTICS INC | 1.9% | $8.7m | 395,000 | -18% | reduced | |
| 12 | TARA PROTARA THERAPEUTICS INC | 1.6% | $7.4m | 1,730,000 | -5% | reduced | |
| 13 | DNA GINKGO BIOWORKS HOLDINGS | 1.5% | $6.8m | 1,195,000 | -0% | held | |
| 14 | GOSSAMER BIO INC | 1.4% | $6.3m | 11,500,000 | 0% | held | |
| 15 | ANIK ANIKA THERAPEUTICS INC | Healthcare | 1.3% | $5.9m | 395,000 | – | new |
| 16 | PTGX PROTAGONIST THERAPEUTICS INC | Healthcare | 1.1% | $5.1m | 105,000 | 0% | held |
| 17 | XOMA CORP DEL | 1.1% | $5.0m | 253,043 | 1% | added | |
| 18 | TRVI TREVI THERAPEUTICS INC | Healthcare | 1.1% | $5.0m | 795,000 | -66% | reduced |
| 19 | PVLA PALVELLA THERAPEUTICS INC | 1.1% | $4.8m | 172,357 | – | new | |
| 20 | GOSS GOSSAMER BIO INC | Healthcare | 1.1% | $4.7m | 4,287,415 | -5% | reduced |
| 21 | ANAB ANAPTYS BIO INC | Healthcare | 1.0% | $4.7m | 250,933 | – | new |
| 22 | KARYOPHARM THERAPEUTICS INC | 1.0% | $4.6m | 6,000,000 | 0% | held | |
| 23 | IRON DISC MEDICINE INC | Healthcare | 0.9% | $4.2m | 85,000 | – | new |
| 24 | LRMR LARIMAR THERAPEUTICS INC | Healthcare | 0.9% | $4.1m | 1,914,077 | – | new |
| 25 | CGON CG ONCOLOGY INC | Healthcare | 0.9% | $4.0m | 163,988 | – | new |
| 26 | ACELYRIN INC | 0.9% | $4.0m | 1,615,000 | -28% | reduced | |
| 27 | RCEL AVITA MEDICAL INC | 0.8% | $3.6m | 440,000 | – | new | |
| 28 | EPIEUR ESSA PHARMA INC | 0.8% | $3.5m | 2,209,998 | 0% | held | |
| 29 | ZNTL ZENTALIS PHARMACEUTICALS INC | Healthcare | 0.7% | $3.2m | 1,985,000 | 12% | added |
| 30 | CRGX CARGO THERAPEUTICS INC | 0.6% | $2.7m | 666,503 | -11% | reduced | |
| 31 | ZYME ZYMEWORKS INC | Healthcare | 0.5% | $2.1m | 175,000 | – | new |
| 32 | BDSX BIODESIX INC | 0.4% | $2.0m | 3,225,000 | -7% | reduced | |
| 33 | STOK STOKE THERAPEUTICS INC | Healthcare | 0.4% | $2.0m | 300,000 | 1100% | added |
| 34 | MBX MBX BIOSCIENCES INC | Healthcare | 0.4% | $1.8m | 250,000 | – | new |
| 35 | OPTNUSD OPTINOSE INC | 0.4% | $1.8m | 193,039 | – | new | |
| 36 | IRD OPUS GENETICS INC | 0.3% | $1.5m | 1,175,000 | – | new | |
| 37 | IBIO IBIO INC | 0.3% | $1.5m | 375,000 | 0% | held | |
| 38 | KINIKSA PHARMACEUTICALS INTL | 0.3% | $1.4m | 62,501 | – | new | |
| 39 | NRIX NURIX THERAPEUTICS INC | Healthcare | 0.3% | $1.4m | 115,000 | -70% | reduced |
| 40 | RZLT REZOLUTE INC | 0.3% | $1.3m | 465,000 | 0% | held | |
| 41 | SGMOQ SANGAMO THERAPEUTICS INC | Healthcare | 0.2% | $691.9k | 1,055,000 | – | new |
| 42 | PEPG PEPGEN INC | Healthcare | 0.1% | $590.1k | 420,000 | 282% | added |
| 43 | DERM JOURNEY MEDICAL CORP | 0.1% | $409.0k | 69,323 | – | new | |
| 44 | VTYXUSD VENTYX BIOSCIENCES INC | 0.0% | $218.5k | 190,000 | -32% | reduced | |
| 45 | ADGM ADAGIO MED HLDGS INC | 0.0% | $92.1k | 110,571 | 0% | held |
Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.