EcoR1 Capital, LLC 13F holdings, Q2 2025
Holdings as of June 30, 2025 · filings on SEC EDGAR · latest filing →
EcoR1 Capital, LLC disclosed 36 US equity positions worth $1.7bn in its Q2 2025 13F filing. The largest position was ZYME at 17.1% of the reported book, followed by APLSUSD and JAZZ. Against the Q1 2025 filing, it opened 6 new positions, added to 5 and reduced 4 among the top 36 holdings.
What did EcoR1 Capital, LLC own in Q2 2025? Top 36 positions
| # | Stock | Sector | Weight | Value | Shares | Δ shares | vs Q1 2025 |
|---|---|---|---|---|---|---|---|
| 1 | ZYME ZYMEWORKS INC | Healthcare | 17.1% | $288.3m | 22,970,388 | 33% | added |
| 2 | APLSUSD APELLIS PHARMACEUTICALS INC | 12.2% | $205.9m | 11,895,808 | 0% | held | |
| 3 | JAZZ JAZZ PHARMACEUTICALS PLC | Healthcare | 10.7% | $181.1m | 1,706,469 | 0% | held |
| 4 | ANAB ANAPTYSBIO INC | Healthcare | 10.4% | $174.9m | 7,880,094 | 0% | held |
| 5 | CRNXGBP CRINETICS PHARMACEUTICALS IN | 7.3% | $123.3m | 4,288,120 | 0% | held | |
| 6 | 2662247D ITEOS THERAPEUTICS INC | 6.3% | $106.6m | 10,688,978 | – | new | |
| 7 | CRSP CRISPR THERAPEUTICS AG | Healthcare | 4.0% | $67.6m | 1,389,276 | 0% | held |
| 8 | QURE UNIQURE NV | 3.3% | $55.6m | 3,988,971 | 0% | held | |
| 9 | TNGX TANGO THERAPEUTICS INC | Healthcare | 3.2% | $54.4m | 10,630,736 | 0% | held |
| 10 | XNCR XENCOR INC | Healthcare | 2.9% | $48.3m | 6,144,767 | 0% | held |
| 11 | IMNM IMMUNOME INC | Healthcare | 2.2% | $37.9m | 4,079,415 | 0% | held |
| 12 | JANX JANUX THERAPEUTICS INC | Healthcare | 2.0% | $34.0m | 1,469,818 | 0% | held |
| 13 | LKFT GALAPAGOS NV | Healthcare | 1.7% | $29.0m | 1,036,945 | 569% | added |
| 14 | ETON ETON PHARMACEUTICALS INC | 1.7% | $28.9m | 2,030,544 | 5% | added | |
| 15 | KURA KURA ONCOLOGY INC | Healthcare | 1.4% | $24.2m | 4,200,000 | 59% | added |
| 16 | AKERO THERAPEUTICS INC | 1.4% | $23.5m | 440,000 | 0% | held | |
| 17 | MDGL MADRIGAL PHARMACEUTICALS INC | Healthcare | 1.3% | $22.7m | 75,000 | 0% | held |
| 18 | NGNE NEUROGENE INC | 1.1% | $19.0m | 1,271,342 | 0% | held | |
| 19 | VRNA VERONA PHARMA PLC | 1.1% | $18.9m | 200,000 | – | new | |
| 20 | TECX TECTONIC THERAPEUTIC INC | Healthcare | 1.1% | $18.6m | 935,121 | 0% | held |
| 21 | ORIC ORIC PHARMACEUTICALS INC | Healthcare | 1.0% | $16.4m | 1,618,068 | -53% | reduced |
| 22 | ALKS ALKERMES PLC | Healthcare | 0.8% | $14.3m | 500,000 | – | new |
| 23 | RNAGBP AVIDITY BIOSCIENCES INC | 0.8% | $14.2m | 500,000 | -10% | reduced | |
| 24 | MBX MBX BIOSCIENCES INC | Healthcare | 0.8% | $13.1m | 1,149,794 | -9% | reduced |
| 25 | VYGR VOYAGER THERAPEUTICS INC | Healthcare | 0.7% | $12.2m | 3,917,546 | 0% | held |
| 26 | PCRX PACIRA BIOSCIENCES INC | Healthcare | 0.6% | $10.9m | 457,471 | – | new |
| 27 | REPL REPLIMUNE GROUP INC | Healthcare | 0.5% | $7.9m | 850,341 | 0% | held |
| 28 | METSERA INC | 0.5% | $7.7m | 271,529 | 443% | added | |
| 29 | ADAPY ADAPTIMMUNE THERAPEUTICS PLC | Healthcare | 0.4% | $6.6m | 27,404,070 | 0% | held |
| 30 | DAWNGBX DAY ONE BIOPHARMACEUTICALS I | 0.3% | $5.6m | 862,068 | 0% | held | |
| 31 | HILLEVAX INC | 0.3% | $4.8m | 2,420,243 | – | new | |
| 32 | ATRA ATARA BIOTHERAPEUTICS INC | 0.3% | $4.4m | 573,183 | 0% | held | |
| 33 | WHWK WHITEHAWK THERAPEUTICS INC | Healthcare | 0.1% | $2.0m | 1,091,417 | -48% | reduced |
| 34 | MGNX MACROGENICS INC | Healthcare | 0.1% | $1.9m | 1,602,717 | – | new |
| 35 | NUVATION BIO INC | 0.1% | $1.9m | 963,333 | 0% | held | |
| 36 | SURROZEN INC | 0.0% | $596.0k | 66,665 | 0% | held |
Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.