EcoR1 Capital, LLC 13F holdings, Q4 2024
Holdings as of December 31, 2024 · filings on SEC EDGAR · latest filing →
EcoR1 Capital, LLC disclosed 55 US equity positions worth $2.5bn in its Q4 2024 13F filing. The largest position was APLSUSD at 15.2% of the reported book, followed by ZYME and CRNXGBP. Against the Q3 2024 filing, it opened 7 new positions, added to 7 and reduced 7 among the top 50 holdings.
What did EcoR1 Capital, LLC own in Q4 2024? Top 50 positions
| # | Stock | Sector | Weight | Value | Shares | Δ shares | vs Q3 2024 |
|---|---|---|---|---|---|---|---|
| 1 | APLSUSD APELLIS PHARMACEUTICALS INC | 15.2% | $379.4m | 11,890,843 | 0% | held | |
| 2 | ZYME ZYMEWORKS INC | Healthcare | 8.8% | $220.0m | 15,028,079 | 12% | added |
| 3 | CRNXGBP CRINETICS PHARMACEUTICALS IN | 8.8% | $219.3m | 4,288,120 | 0% | held | |
| 4 | JAZZ JAZZ PHARMACEUTICALS PLC | Healthcare | 8.4% | $210.2m | 1,706,469 | 0% | held |
| 5 | PROTHENA CORP PLC | 6.4% | $160.4m | 11,584,280 | 0% | held | |
| 6 | XNCR XENCOR INC | Healthcare | 5.6% | $141.2m | 6,144,767 | 15% | added |
| 7 | ARVN ARVINAS INC | Healthcare | 5.2% | $128.9m | 6,726,491 | 0% | held |
| 8 | ANAB ANAPTYSBIO INC | Healthcare | 4.2% | $104.2m | 7,873,448 | 1% | added |
| 9 | SRPT SAREPTA THERAPEUTICS INC | Healthcare | 3.7% | $93.6m | 770,000 | – | new |
| 10 | JANX JANUX THERAPEUTICS INC | Healthcare | 3.1% | $78.7m | 1,469,818 | 0% | held |
| 11 | QURE UNIQURE NV | 2.4% | $60.0m | 3,400,000 | – | new | |
| 12 | SWTXUSD SPRINGWORKS THERAPEUTICS INC | 2.3% | $56.4m | 1,560,000 | – | new | |
| 13 | CRSP CRISPR THERAPEUTICS AG | Healthcare | 2.2% | $54.7m | 1,389,276 | 0% | held |
| 14 | IMNM IMMUNOME INC | Healthcare | 1.6% | $41.2m | 3,879,415 | 0% | held |
| 15 | TECX TECTONIC THERAPEUTIC INC | Healthcare | 1.6% | $39.2m | 849,143 | 0% | held |
| 16 | TNGX TANGO THERAPEUTICS INC | Healthcare | 1.3% | $32.8m | 10,630,736 | -20% | reduced |
| 17 | THIRD HARMONIC BIO INC | 1.3% | $32.7m | 3,182,444 | 0% | held | |
| 18 | KURA KURA ONCOLOGY INC | Healthcare | 1.2% | $31.0m | 3,557,269 | -39% | reduced |
| 19 | NGNE NEUROGENE INC | 1.2% | $29.1m | 1,271,342 | 0% | held | |
| 20 | ORIC ORIC PHARMACEUTICALS INC | Healthcare | 1.1% | $27.6m | 3,418,068 | 0% | held |
| 21 | ETON ETON PHARMACEUTICALS INC | 1.0% | $24.4m | 1,829,603 | 223% | added | |
| 22 | MBX MBX BIOSCIENCES INC | Healthcare | 0.9% | $23.2m | 1,259,273 | 7% | added |
| 23 | MDGL MADRIGAL PHARMACEUTICALS INC | Healthcare | 0.9% | $23.1m | 75,000 | 0% | held |
| 24 | VYGR VOYAGER THERAPEUTICS INC | Healthcare | 0.9% | $22.2m | 3,917,546 | 0% | held |
| 25 | NMRA NEUMORA THERAPEUTICS INC. | Healthcare | 0.9% | $22.0m | 2,071,450 | 0% | held |
| 26 | CRGX CARGO THERAPEUTICS INC | 0.8% | $21.2m | 1,470,000 | 0% | held | |
| 27 | MLTX MOONLAKE IMMUNOTHERAPEUTICS | Healthcare | 0.7% | $18.0m | 332,522 | – | new |
| 28 | DNA GINKGO BIOWORKS HOLDINGS INC | 0.7% | $17.1m | 1,743,344 | – | new | |
| 29 | RNAGBP AVIDITY BIOSCIENCES INC | 0.6% | $16.2m | 557,576 | -26% | reduced | |
| 30 | MERSANA THERAPEUTICS INC | 0.6% | $16.2m | 11,328,000 | -42% | reduced | |
| 31 | TCRX TSCAN THERAPEUTICS INC | 0.6% | $15.2m | 5,000,000 | 0% | held | |
| 32 | ADAPY ADAPTIMMUNE THERAPEUTICS PLC | Healthcare | 0.6% | $14.8m | 27,404,070 | 0% | held |
| 33 | KYMR KYMERA THERAPEUTICS INC | Healthcare | 0.6% | $14.1m | 350,000 | – | new |
| 34 | DYN DYNE THERAPEUTICS INC | Healthcare | 0.5% | $13.1m | 555,644 | 0% | held |
| 35 | BCYC BICYCLE THERAPEUTICS PLC | Healthcare | 0.5% | $12.7m | 910,000 | 0% | held |
| 36 | AVIR ATEA PHARMACEUTICALS INC | Healthcare | 0.4% | $11.2m | 3,341,653 | -39% | reduced |
| 37 | DAWNGBX DAY ONE BIOPHARMACEUTICALS I | 0.4% | $10.9m | 862,068 | 0% | held | |
| 38 | REPL REPLIMUNE GROUP INC | Healthcare | 0.4% | $10.3m | 850,341 | 0% | held |
| 39 | ALGS ALIGOS THERAPEUTICS INC | 0.4% | $10.2m | 255,573 | 0% | held | |
| 40 | ATRA ATARA BIOTHERAPEUTICS INC | 0.3% | $7.1m | 532,134 | 13% | added | |
| 41 | VERVE THERAPEUTICS INC | 0.3% | $7.0m | 1,250,000 | 0% | held | |
| 42 | FATE FATE THERAPEUTICS INC | Healthcare | 0.2% | $5.0m | 3,049,405 | – | new |
| 43 | LKFT GALAPAGOS NV | Healthcare | 0.2% | $4.3m | 155,006 | 0% | held |
| 44 | ALLOVIR INC | 0.2% | $3.9m | 408,688 | -96% | reduced | |
| 45 | KROS KEROS THERAPEUTICS INC | Healthcare | 0.1% | $3.0m | 187,500 | 0% | held |
| 46 | RLAY RELAY THERAPEUTICS INC | Healthcare | 0.1% | $2.6m | 641,426 | -74% | reduced |
| 47 | DSGN DESIGN THERAPEUTICS INC | Healthcare | 0.1% | $2.6m | 426,683 | 693% | added |
| 48 | NUVATION BIO INC | 0.1% | $2.6m | 963,333 | 0% | held | |
| 49 | GBIOGBX GENERATION BIO CO | 0.1% | $2.2m | 2,046,867 | 0% | held | |
| 50 | PRME PRIME MEDICINE INC | 0.1% | $2.0m | 700,000 | 0% | held |
Weights are shares of the reported long US equity book (options excluded). Values are as filed, normalised to whole dollars. Share changes compare against the immediately preceding filing only.